Nakayama M - Search Results

1

Missense Mutant p53 Transactivates Wnt/β-Catenin Signaling in Neighboring p53-Destabilized Cells through the COX-2/PGE2 Pathway.

Nakayama M, Saito H, Murakami K, Oshima H, Oshima M. Nakayama M, et al. Cancer Res Commun. 2025 Jan 1;5(1):13-23. doi: 10.1158/2767-9764.CRC-24-0471. Cancer Res Commun. 2025. PMID: 39641656 Free article.

2

Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer.

Oshima H, Nakayama M, Han TS, Naoi K, Ju X, Maeda Y, Robine S, Tsuchiya K, Sato T, Sato H, Taketo MM, Oshima M. Oshima H, et al. Among authors: nakayama m. Cancer Res. 2015 Feb 15;75(4):766-76. doi: 10.1158/0008-5472.CAN-14-2036. Cancer Res. 2015. PMID: 25687406

3

Combined Mutation of Apc, Kras, and Tgfbr2 Effectively Drives Metastasis of Intestinal Cancer.

Sakai E, Nakayama M, Oshima H, Kouyama Y, Niida A, Fujii S, Ochiai A, Nakayama KI, Mimori K, Suzuki Y, Hong CP, Ock CY, Kim SJ, Oshima M. Sakai E, et al. Among authors: nakayama ki, nakayama m. Cancer Res. 2018 Mar 1;78(5):1334-1346. doi: 10.1158/0008-5472.CAN-17-3303. Epub 2017 Dec 27. Cancer Res. 2018. PMID: 29282223

4

Mutant p53 in colon cancer.

Nakayama M, Oshima M. Nakayama M, et al. J Mol Cell Biol. 2019 Apr 1;11(4):267-276. doi: 10.1093/jmcb/mjy075. J Mol Cell Biol. 2019. PMID: 30496442 Free PMC article. Review.

5

Loss of wild-type p53 promotes mutant p53-driven metastasis through acquisition of survival and tumor-initiating properties.

Nakayama M, Hong CP, Oshima H, Sakai E, Kim SJ, Oshima M. Nakayama M, et al. Nat Commun. 2020 May 11;11(1):2333. doi: 10.1038/s41467-020-16245-1. Nat Commun. 2020. PMID: 32393735 Free PMC article.

6

Gain-of-Function p53 Mutation Acts as a Genetic Switch for TGFβ Signaling-Induced Epithelial-to-Mesenchymal Transition in Intestinal Tumors.

Wang D, Nakayama M, Hong CP, Oshima H, Oshima M. Wang D, et al. Among authors: nakayama m. Cancer Res. 2024 Jan 2;84(1):56-68. doi: 10.1158/0008-5472.CAN-23-1490. Cancer Res. 2024. PMID: 37851521 Free PMC article.

7

Intestinal cancer progression by mutant p53 through the acquisition of invasiveness associated with complex glandular formation.

Nakayama M, Sakai E, Echizen K, Yamada Y, Oshima H, Han TS, Ohki R, Fujii S, Ochiai A, Robine S, Voon DC, Tanaka T, Taketo MM, Oshima M. Nakayama M, et al. Oncogene. 2017 Oct 19;36(42):5885-5896. doi: 10.1038/onc.2017.194. Epub 2017 Jun 19. Oncogene. 2017. PMID: 28628120 Free PMC article.

8

The inflammatory microenvironment that promotes gastrointestinal cancer development and invasion.

Echizen K, Oshima H, Nakayama M, Oshima M. Echizen K, et al. Among authors: nakayama m. Adv Biol Regul. 2018 May;68:39-45. doi: 10.1016/j.jbior.2018.02.001. Epub 2018 Feb 5. Adv Biol Regul. 2018. PMID: 29428221 Review.

9

Stat3 is indispensable for damage-induced crypt regeneration but not for Wnt-driven intestinal tumorigenesis.

Oshima H, Kok SY, Nakayama M, Murakami K, Voon DC, Kimura T, Oshima M. Oshima H, et al. Among authors: nakayama m. FASEB J. 2019 Feb;33(2):1873-1886. doi: 10.1096/fj.201801176R. Epub 2018 Aug 29. FASEB J. 2019. PMID: 30156908 Free PMC article.

These results indicate that Stat3 is indispensable for the survival of epithelial cells through the activation of integrin signaling and the downstream FAK pathway; however, it is not required for the Wnt signaling-activated normal or tumor epithelial cells.-Oshima, H., Kok, S.-Y …

These results indicate that Stat3 is indispensable for the survival of epithelial cells through the activation of integrin signaling and the …

10

Malignant subclone drives metastasis of genetically and phenotypically heterogenous cell clusters through fibrotic niche generation.

Kok SY, Oshima H, Takahashi K, Nakayama M, Murakami K, Ueda HR, Miyazono K, Oshima M. Kok SY, et al. Among authors: nakayama m. Nat Commun. 2021 Feb 8;12(1):863. doi: 10.1038/s41467-021-21160-0. Nat Commun. 2021. PMID: 33558489 Free PMC article.

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