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A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties.
Laghezza A, Cerchia C, Genovese M, Montanari R, Capelli D, Wackerlig J, Simic S, Falbo E, Pecora L, Leuci R, Brunetti L, Piemontese L, Tortorella P, Biswas A, Singh RP, Tambe S, Sudeep CA, Pattnaik AK, Jayaprakash V, Paoli P, Lavecchia A, Loiodice F. Laghezza A, et al. Among authors: singh rp. Eur J Med Chem. 2024 Sep 5;275:116567. doi: 10.1016/j.ejmech.2024.116567. Epub 2024 Jun 9. Eur J Med Chem. 2024. PMID: 38865743
A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition.
Laghezza A, Cerchia C, Genovese M, Leuci R, Pranzini E, Santi A, Brunetti L, Piemontese L, Tortorella P, Biswas A, Singh RP, Tambe S, Ca S, Pattnaik AK, Jayaprakash V, Paoli P, Lavecchia A, Loiodice F. Laghezza A, et al. Among authors: singh rp. J Med Chem. 2023 Mar 9;66(5):3566-3587. doi: 10.1021/acs.jmedchem.2c02093. Epub 2023 Feb 15. J Med Chem. 2023. PMID: 36790935
A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects.
Yasmin S, Cerchia C, Badavath VN, Laghezza A, Dal Piaz F, Mondal SK, Atlı Ö, Baysal M, Vadivelan S, Shankar S, Siddique MUM, Pattnaik AK, Singh RP, Loiodice F, Jayaprakash V, Lavecchia A. Yasmin S, et al. Among authors: singh rp. ChemMedChem. 2021 Feb 4;16(3):484-498. doi: 10.1002/cmdc.202000564. Epub 2020 Oct 29. ChemMedChem. 2021. PMID: 33030290
Risk assessment models: considerations prior to use in clinical practice.
Darzi AJ, Busse JW, Torabiardakani K, Phillips M, Thabane L, Bhandari M, Borrelli E, Steel DH, Wykoff CC, Chaudhary V; Retina Evidence and Trials INternational Alliance (R.E.T.I.N.A.) Study Group. Darzi AJ, et al. Eye (Lond). 2024 Dec 18. doi: 10.1038/s41433-024-03557-5. Online ahead of print. Eye (Lond). 2024. PMID: 39695254 No abstract available.
2,173 results