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Tertiary lymphoid structures in pancreatic cancer are structurally homologous, share gene expression patterns and B-cell clones with secondary lymphoid organs but show increased T-cell activation.
Lehmann J, Thelen M, Kreer C, Schran S, García-Marquez MA, Cisic I, Siepmann K, Hagen EM, Eckel HNC, Lohneis P, Kruger S, Boeck S, Ormanns S, Rudelius M, Werner J, Popp F, Klein F, von Bergwelt-Baildon MS, Bruns CJ, Quaas A, Wennhold K, Schlößer HA. Lehmann J, et al. Among authors: cisic i. Cancer Immunol Res. 2024 Dec 11. doi: 10.1158/2326-6066.CIR-24-0299. Online ahead of print. Cancer Immunol Res. 2024. PMID: 39661055