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Page 1
Mechanisms underlying dilated cardiomyopathy associated with FKBP12 deficiency.
Hanna AD, Chang T, Ho KS, Yee RSZ, Walker WC, Agha N, Hsu CW, Jung SY, Dickinson ME, Samee MAH, Ward CS, Lee CS, Rodney GG, Hamilton SL. Hanna AD, et al. Among authors: hamilton sl. J Gen Physiol. 2025 Jan 6;157(1):e202413583. doi: 10.1085/jgp.202413583. Epub 2024 Dec 11. J Gen Physiol. 2025. PMID: 39661086
Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function.
Lee CS, Georgiou DK, Dagnino-Acosta A, Xu J, Ismailov II, Knoblauch M, Monroe TO, Ji R, Hanna AD, Joshi AD, Long C, Oakes J, Tran T, Corona BT, Lorca S, Ingalls CP, Narkar VA, Lanner JT, Bayle JH, Durham WJ, Hamilton SL. Lee CS, et al. Among authors: hamilton sl. J Biol Chem. 2014 Sep 12;289(37):25556-70. doi: 10.1074/jbc.M114.586289. Epub 2014 Jul 22. J Biol Chem. 2014. PMID: 25053409 Free PMC article.
Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads.
Lee CS, Jung SY, Yee RSZ, Agha NH, Hong J, Chang T, Babcock LW, Fleischman JD, Clayton B, Hanna AD, Ward CS, Lanza D, Hurley AE, Zhang P, Wehrens XHT, Lagor WR, Rodney GG, Hamilton SL. Lee CS, et al. Among authors: hamilton sl. Commun Biol. 2023 Sep 14;6(1):942. doi: 10.1038/s42003-023-05330-y. Commun Biol. 2023. PMID: 37709832 Free PMC article.
AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation.
Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL. Lanner JT, et al. Among authors: hamilton sl. Nat Med. 2012 Jan 8;18(2):244-51. doi: 10.1038/nm.2598. Nat Med. 2012. PMID: 22231556 Free PMC article.
Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function.
Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Poché RA, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, Dickinson ME, Beeton C, Zhang P, Dirksen RT, Hamilton SL. Lee CS, et al. Among authors: hamilton sl. Skelet Muscle. 2015 Jan 29;5:4. doi: 10.1186/s13395-014-0027-1. eCollection 2015. Skelet Muscle. 2015. PMID: 25717360 Free PMC article.
A chemical chaperone improves muscle function in mice with a RyR1 mutation.
Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SL. Lee CS, et al. Among authors: hamilton sl. Nat Commun. 2017 Mar 24;8:14659. doi: 10.1038/ncomms14659. Nat Commun. 2017. PMID: 28337975 Free PMC article.
Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation.
Wang HJ, Lee CS, Yee RSZ, Groom L, Friedman I, Babcock L, Georgiou DK, Hong J, Hanna AD, Recio J, Choi JM, Chang T, Agha NH, Romero J, Sarkar P, Voermans N, Gaber MW, Jung SY, Baker ML, Pautler RG, Dirksen RT, Riazi S, Hamilton SL. Wang HJ, et al. Among authors: hamilton sl. Nat Commun. 2020 Oct 9;11(1):5099. doi: 10.1038/s41467-020-18865-z. Nat Commun. 2020. PMID: 33037202 Free PMC article.
166 results