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HKB99, an allosteric inhibitor of phosphoglycerate mutase 1, suppresses invasive pseudopodia formation and upregulates plasminogen activator inhibitor-2 in erlotinib-resistant non-small cell lung cancer cells.
Liang Q, Gu WM, Huang K, Luo MY, Zou JH, Zhuang GL, Lei HM, Chen HZ, Zhu L, Zhou L, Shen Y. Liang Q, et al. Among authors: chen hz. Acta Pharmacol Sin. 2021 Jan;42(1):115-119. doi: 10.1038/s41401-020-0399-1. Epub 2020 May 13. Acta Pharmacol Sin. 2021. PMID: 32404981 Free PMC article.
A phosphoglycerate mutase 1 allosteric inhibitor overcomes drug resistance to EGFR-targeted therapy via disrupting IL-6/JAK2/STAT3 signaling pathway in lung adenocarcinoma.
Liang Q, Gong M, Zou JH, Luo MY, Jiang LL, Wang C, Shen NX, Zhang MC, Xu L, Lei HM, Zhang KR, Zhang R, Zhuang G, Zhu L, Chen HZ, Zhou L, Shen Y. Liang Q, et al. Among authors: chen hz. Drug Resist Updat. 2023 May;68:100957. doi: 10.1016/j.drup.2023.100957. Epub 2023 Mar 16. Drug Resist Updat. 2023. PMID: 36990047 Free article.
A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer.
Huang K, Liang Q, Zhou Y, Jiang LL, Gu WM, Luo MY, Tang YB, Wang Y, Lu W, Huang M, Zhang SZ, Zhuang GL, Dai Q, Shen QC, Zhang J, Lei HM, Zhu L, Ye DY, Chen HZ, Zhou L, Shen Y. Huang K, et al. Among authors: chen hz. Cell Metab. 2019 Dec 3;30(6):1107-1119.e8. doi: 10.1016/j.cmet.2019.09.014. Epub 2019 Oct 10. Cell Metab. 2019. PMID: 31607564 Free article.
Cancer cell-autonomous cGAS-STING response confers drug resistance.
Lv QM, Lei HM, Wang SY, Zhang KR, Tang YB, Shen Y, Lu LM, Chen HZ, Zhu L. Lv QM, et al. Among authors: chen hz. Cell Chem Biol. 2023 Jun 15;30(6):591-605.e4. doi: 10.1016/j.chembiol.2023.05.005. Epub 2023 May 31. Cell Chem Biol. 2023. PMID: 37263275 Free article.
803 results