Hirokawa T - Search Results

1

Deep mutational scanning-guided design of a high-affinity helix-loop-helix peptide targeting G-CSF receptor.

Michigami M, Kanata Y, Ven CI, Oshima A, Yamaguchi-Nomoto A, Kinoshita T, Hirokawa T, Fujii I. Michigami M, et al. Among authors: hirokawa t. Bioorg Med Chem Lett. 2024 Dec 10;117:130071. doi: 10.1016/j.bmcl.2024.130071. Online ahead of print. Bioorg Med Chem Lett. 2024. PMID: 39667506

2

Structural insights into molecular-targeting helix-loop-helix peptide against vascular endothelial growth factor-A.

Michigami M, Notsu K, Kamo M, Hirokawa T, Kinoshita T, Inaka K, Nakase I, Fujii I. Michigami M, et al. Among authors: hirokawa t. Biochem Biophys Res Commun. 2024 Nov 19;734:150749. doi: 10.1016/j.bbrc.2024.150749. Epub 2024 Sep 27. Biochem Biophys Res Commun. 2024. PMID: 39357335 Free article.

3

Structural Insights into Helix-Loop-Helix Peptides for "Ligand-Targeting" Intracellular Drug Delivery via VEGF Receptor-Mediated Endocytosis.

Michigami M, Kira R, Kamo M, Hirokawa T, Kinoshita T, Inaka K, Nakase I, Fujii I. Michigami M, et al. Among authors: hirokawa t. Biochem Biophys Res Commun. 2024 Dec 31;741:150980. doi: 10.1016/j.bbrc.2024.150980. Epub 2024 Nov 12. Biochem Biophys Res Commun. 2024. PMID: 39580956

4

Lipid bilayer membrane permeability mechanism of the K-Ras(G12D)-inhibitory bicyclic peptide KS-58 elucidated by molecular dynamics simulations.

Sakamoto K, Hirokawa T. Sakamoto K, et al. Among authors: hirokawa t. Bioorg Med Chem Lett. 2024 Mar 1;100:129649. doi: 10.1016/j.bmcl.2024.129649. Epub 2024 Feb 9. Bioorg Med Chem Lett. 2024. PMID: 38341162

5

Prediction of the binding mechanism of a selective DNA methyltransferase 3A inhibitor by molecular simulation.

Kudo G, Hirao T, Harada R, Hirokawa T, Shigeta Y, Yoshino R. Kudo G, et al. Among authors: hirokawa t. Sci Rep. 2024 Jun 12;14(1):13508. doi: 10.1038/s41598-024-64236-9. Sci Rep. 2024. PMID: 38866895 Free PMC article.

6

AlphaFold version 2.0 elucidates the binding mechanism between VIPR2 and KS-133, and reveals an S-S bond (Cys²⁵-Cys¹⁹²) formation of functional significance for VIPR2.

Sakamoto K, Asano S, Ago Y, Hirokawa T. Sakamoto K, et al. Among authors: hirokawa t. Biochem Biophys Res Commun. 2022 Dec 25;636(Pt 1):10-16. doi: 10.1016/j.bbrc.2022.10.071. Epub 2022 Oct 23. Biochem Biophys Res Commun. 2022. PMID: 36332470

7

AAp-MSMD: Amino Acid Preference Mapping on Protein-Protein Interaction Surfaces Using Mixed-Solvent Molecular Dynamics.

Kudo G, Yanagisawa K, Yoshino R, Hirokawa T. Kudo G, et al. Among authors: hirokawa t. J Chem Inf Model. 2023 Dec 25;63(24):7768-7777. doi: 10.1021/acs.jcim.3c01677. Epub 2023 Dec 12. J Chem Inf Model. 2023. PMID: 38085669 Free PMC article.

8

Differential Metabolic Stability of 4α,25- and 4β,25-Dihydroxyvitamin D₃ and Identification of Their Metabolites.

Mizumoto Y, Sakamoto R, Iijima K, Nakaya N, Odagi M, Tera M, Hirokawa T, Sakaki T, Yasuda K, Nagasawa K. Mizumoto Y, et al. Among authors: hirokawa t. Biomolecules. 2023 Jun 24;13(7):1036. doi: 10.3390/biom13071036. Biomolecules. 2023. PMID: 37509072 Free PMC article.

9

Biological Evaluation of Isosteric Applicability of 1,3-Substituted Cuneanes as m-Substituted Benzenes Enabled by Selective Isomerization of 1,4-Substituted Cubanes.

Fujiwara K, Nagasawa S, Maeyama R, Segawa R, Hirasawa N, Hirokawa T, Iwabuchi Y. Fujiwara K, et al. Among authors: hirokawa t. Chemistry. 2024 Feb 21;30(11):e202303548. doi: 10.1002/chem.202303548. Epub 2024 Jan 11. Chemistry. 2024. PMID: 38012076

10

Topology-selective photo-crosslinking of G-quadruplexes via dual G-quartet and groove recognition.

Ishikawa R, Yanagita K, Shimada S, Sasaki S, Hirokawa T, Ma Y, Nagasawa K, Tera M. Ishikawa R, et al. Among authors: hirokawa t. Chem Commun (Camb). 2024 Nov 14;60(92):13550-13553. doi: 10.1039/d4cc04804k. Chem Commun (Camb). 2024. PMID: 39474792

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