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Copper chelation redirects neutrophil function to enhance anti-GD2 antibody therapy in neuroblastoma.
Rouaen JRC, Salerno A, Shai-Hee T, Murray JE, Castrogiovanni G, McHenry C, Jue TR, Pham V, Bell JL, Poursani E, Valli E, Cazzoli R, Damstra N, Nelson DJ, Stevens KLP, Chee J, Slapetova I, Kasherman M, Whan R, Lin F, Cochran BJ, Tedla N, Veli FC, Yuksel A, Mayoh C, Saletta F, Mercatelli D, Chtanova T, Kulasinghe A, Catchpoole D, Cirillo G, Biro M, Lode HN, Luciani F, Haber M, Gray JC, Trahair TN, Vittorio O. Rouaen JRC, et al. Among authors: stevens klp. Nat Commun. 2024 Dec 12;15(1):10462. doi: 10.1038/s41467-024-54689-x. Nat Commun. 2024. PMID: 39668192 Free PMC article.
Anti-metabolite chemotherapy increases LAG-3 expressing tumor-infiltrating lymphocytes which can be targeted by combination immune checkpoint blockade.
Principe N, Phung AL, Stevens KLP, Elaskalani O, Wylie B, Tilsed CM, Sheikh F, Orozco Morales ML, Kidman J, Marcq E, Fisher SA, Nowak AK, McDonnell AM, Lesterhuis WJ, Chee J. Principe N, et al. Among authors: stevens klp. J Immunother Cancer. 2024 Sep 28;12(9):e008568. doi: 10.1136/jitc-2023-008568. J Immunother Cancer. 2024. PMID: 39343508 Free PMC article.