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SARS-CoV-2 3CLpro (main protease) regulates caspase activation of gasdermin-D/E pores leading to secretion and extracellular activity of 3CLpro.
Grin PM, Baid K, de Jesus HCR, Kozarac N, Bell PA, Jiang SZ, Kappelhoff R, Butler GS, Leborgne NGF, Pan C, Pablos I, Machado Y, Vederas JC, Kim H, Benarafa C, Banerjee A, Overall CM. Grin PM, et al. Among authors: kappelhoff r. Cell Rep. 2024 Dec 24;43(12):115080. doi: 10.1016/j.celrep.2024.115080. Epub 2024 Dec 12. Cell Rep. 2024. PMID: 39673710 Free article.
Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CLpro substrate degradome.
Pablos I, Machado Y, de Jesus HCR, Mohamud Y, Kappelhoff R, Lindskog C, Vlok M, Bell PA, Butler GS, Grin PM, Cao QT, Nguyen JP, Solis N, Abbina S, Rut W, Vederas JC, Szekely L, Szakos A, Drag M, Kizhakkedathu JN, Mossman K, Hirota JA, Jan E, Luo H, Banerjee A, Overall CM. Pablos I, et al. Among authors: kappelhoff r. Cell Rep. 2021 Oct 26;37(4):109892. doi: 10.1016/j.celrep.2021.109892. Epub 2021 Oct 9. Cell Rep. 2021. PMID: 34672947 Free PMC article.
Optimization of quenched fluorescent peptide substrates of SARS-CoV-2 3CLpro main protease (Mpro) from proteomic identification of P6-P6' active site specificity.
Cesar Ramos de Jesus H, Solis N, Machado Y, Pablos I, Bell PA, Kappelhoff R, Grin PM, Sorgi CA, Butler GS, Overall CM. Cesar Ramos de Jesus H, et al. Among authors: kappelhoff r. J Virol. 2024 Jun 13;98(6):e0004924. doi: 10.1128/jvi.00049-24. Epub 2024 May 14. J Virol. 2024. PMID: 38742901 Free PMC article.
Macrophage matrix metalloproteinase-12 dampens inflammation and neutrophil influx in arthritis.
Bellac CL, Dufour A, Krisinger MJ, Loonchanta A, Starr AE, Auf dem Keller U, Lange PF, Goebeler V, Kappelhoff R, Butler GS, Burtnick LD, Conway EM, Roberts CR, Overall CM. Bellac CL, et al. Among authors: kappelhoff r. Cell Rep. 2014 Oct 23;9(2):618-32. doi: 10.1016/j.celrep.2014.09.006. Epub 2014 Oct 9. Cell Rep. 2014. PMID: 25310974 Free article.
Overview of transcriptomic analysis of all human proteases, non-proteolytic homologs and inhibitors: Organ, tissue and ovarian cancer cell line expression profiling of the human protease degradome by the CLIP-CHIP™ DNA microarray.
Kappelhoff R, Puente XS, Wilson CH, Seth A, López-Otín C, Overall CM. Kappelhoff R, et al. Biochim Biophys Acta Mol Cell Res. 2017 Nov;1864(11 Pt B):2210-2219. doi: 10.1016/j.bbamcr.2017.08.004. Epub 2017 Aug 7. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28797648 Free article. Review.
Active site specificity profiling datasets of matrix metalloproteinases (MMPs) 1, 2, 3, 7, 8, 9, 12, 13 and 14.
Eckhard U, Huesgen PF, Schilling O, Bellac CL, Butler GS, Cox JH, Dufour A, Goebeler V, Kappelhoff R, Auf dem Keller U, Klein T, Lange PF, Marino G, Morrison CJ, Prudova A, Rodriguez D, Starr AE, Wang Y, Overall CM. Eckhard U, et al. Among authors: kappelhoff r. Data Brief. 2016 Feb 22;7:299-310. doi: 10.1016/j.dib.2016.02.036. eCollection 2016 Jun. Data Brief. 2016. PMID: 26981551 Free PMC article.
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