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Inhibition of L-Threonine Dehydrogenase from Trypanosoma cruzi reduces glycine and acetate production and interferes with parasite growth and viability.
Faria JDN, Eufrásio AG, Fagundes M, Lobo-Rojas A, Marchese L, de Lima Silva CC, Bezerra EHS, Mercaldi GF, Alborghetti MR, Sforca ML, Cordeiro AT. Faria JDN, et al. Among authors: sforca ml. J Biol Chem. 2024 Dec 13:108080. doi: 10.1016/j.jbc.2024.108080. Online ahead of print. J Biol Chem. 2024. PMID: 39675710 Free article.
Metabolite Profiling of Pleurotus ostreatus Grown on Sisal Agro-Industrial Waste Supplemented with Cocoa Almond Tegument and Wheat Bran.
Ferraz CG, Ribeiro PR, Verde BV, Dos S Silva R, do Carmo C Silva M, do Carmo CO, Bazioli JM, Dos Santos IBF, Fill TP, Sforca ML, Silva F, da S Magaton A, Soares ACF. Ferraz CG, et al. Among authors: sforca ml. Chem Biodivers. 2023 Sep;20(9):e202300346. doi: 10.1002/cbdv.202300346. Epub 2023 Aug 14. Chem Biodivers. 2023. PMID: 37503864
Metformin acts in the gut and induces gut-liver crosstalk.
Tobar N, Rocha GZ, Santos A, Guadagnini D, Assalin HB, Camargo JA, Gonçalves AESS, Pallis FR, Oliveira AG, Rocco SA, Neto RM, de Sousa IL, Alborghetti MR, Sforça ML, Rodrigues PB, Ludwig RG, Vanzela EC, Brunetto SQ, Boer PA, Gontijo JAR, Geloneze B, Carvalho CRO, Prada PO, Folli F, Curi R, Mori MA, Vinolo MAR, Ramos CD, Franchini KG, Tormena CF, Saad MJA. Tobar N, et al. Among authors: sforca ml. Proc Natl Acad Sci U S A. 2023 Jan 24;120(4):e2211933120. doi: 10.1073/pnas.2211933120. Epub 2023 Jan 19. Proc Natl Acad Sci U S A. 2023. PMID: 36656866 Free PMC article.
Discovery and structural characterization of chicoric acid as a SARS-CoV-2 nucleocapsid protein ligand and RNA binding disruptor.
Mercaldi GF, Bezerra EHS, Batista FAH, Tonoli CCC, Soprano AS, Shimizu JF, Nagai A, da Silva JC, Filho HVR, do Nascimento Faria J, da Cunha MG, Zeri ACM, Nascimento AFZ, Proenca-Modena JL, Bajgelman MC, Rocco SA, Lopes-de-Oliveira PS, Cordeiro AT, Bruder M, Marques RE, Sforça ML, Franchini KG, Benedetti CE, Figueira ACM, Trivella DBB. Mercaldi GF, et al. Among authors: sforca ml. Sci Rep. 2022 Nov 2;12(1):18500. doi: 10.1038/s41598-022-22576-4. Sci Rep. 2022. PMID: 36323732 Free PMC article.
Metabolomics by NMR Combined with Machine Learning to Predict Neoadjuvant Chemotherapy Response for Breast Cancer.
Cardoso MR, Silva AAR, Talarico MCR, Sanches PHG, Sforça ML, Rocco SA, Rezende LM, Quintero M, Costa TBBC, Viana LR, Canevarolo RR, Ferracini AC, Ramalho S, Gutierrez JM, Guimarães F, Tasic L, Tata A, Sarian LO, Cheng LL, Porcari AM, Derchain SFM. Cardoso MR, et al. Among authors: sforca ml. Cancers (Basel). 2022 Oct 15;14(20):5055. doi: 10.3390/cancers14205055. Cancers (Basel). 2022. PMID: 36291837 Free PMC article.
Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides.
Cabral L, Persinoti GF, Paixão DAA, Martins MP, Morais MAB, Chinaglia M, Domingues MN, Sforca ML, Pirolla RAS, Generoso WC, Santos CA, Maciel LF, Terrapon N, Lombard V, Henrissat B, Murakami MT. Cabral L, et al. Among authors: sforca ml. Nat Commun. 2022 Feb 2;13(1):629. doi: 10.1038/s41467-022-28310-y. Nat Commun. 2022. PMID: 35110564 Free PMC article.
46 results