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Page 1
The zymogenic form of SARS-CoV-2 main protease: A discrete target for drug discovery.
Novotný P, Humpolíčková J, Nováková V, Stanchev S, Stříšovský K, Zgarbová M, Weber J, Kryštůfek R, Starková J, Hradilek M, Moravcová A, Günterová J, Bach K, Majer P, Konvalinka J, Majerová T. Novotný P, et al. Among authors: hradilek m. J Biol Chem. 2024 Dec 13:108079. doi: 10.1016/j.jbc.2024.108079. Online ahead of print. J Biol Chem. 2024. PMID: 39675720 Free article.
Re-emerging Aspartic Protease Targets: Examining Cryptococcus neoformans Major Aspartyl Peptidase 1 as a Target for Antifungal Drug Discovery.
Kryštůfek R, Šácha P, Starková J, Brynda J, Hradilek M, Tloušt'ová E, Grzymska J, Rut W, Boucher MJ, Drąg M, Majer P, Hájek M, Řezáčová P, Madhani HD, Craik CS, Konvalinka J. Kryštůfek R, et al. Among authors: hradilek m. J Med Chem. 2021 May 27;64(10):6706-6719. doi: 10.1021/acs.jmedchem.0c02177. Epub 2021 May 18. J Med Chem. 2021. PMID: 34006103 Free PMC article.
Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex.
Brynda J, Rezácová P, Fábry M, Horejsí M, Stouracová R, Soucek M, Hradílek M, Konvalinka J, Sedlácek J. Brynda J, et al. Among authors: hradilek m. Acta Crystallogr D Biol Crystallogr. 2004 Nov;60(Pt 11):1943-8. doi: 10.1107/S0907444904021572. Epub 2004 Oct 20. Acta Crystallogr D Biol Crystallogr. 2004. PMID: 15502300
On the role of the R configuration of the reaction-intermediate isostere in HIV-1 protease-inhibitor binding: X-ray structure at 2.0 A resolution.
Dusková J, Dohnálek J, Skálová T, Petroková H, Vondrácková E, Hradílek M, Konvalinka J, Soucek M, Brynda J, Fábry M, Sedlácek J, Hasek J. Dusková J, et al. Among authors: hradilek m. Acta Crystallogr D Biol Crystallogr. 2006 May;62(Pt 5):489-97. doi: 10.1107/S0907444906006718. Epub 2006 Apr 19. Acta Crystallogr D Biol Crystallogr. 2006. PMID: 16627941
Configurations of diastereomeric hydroxyethylene isosteres strongly affect biological activities of a series of specific inhibitors of human-immunodeficiency-virus proteinase.
Konvalinka J, Litera J, Weber J, Vondrásek J, Hradílek M, Soucek M, Pichová I, Majer P, Strop P, Sedlácek J, Heuser AM, Kottler H, Kräusslich HG. Konvalinka J, et al. Among authors: hradilek m. Eur J Biochem. 1997 Dec 1;250(2):559-66. doi: 10.1111/j.1432-1033.1997.0559a.x. Eur J Biochem. 1997. PMID: 9428710 Free article.
Hydroxyethylamine isostere of an HIV-1 protease inhibitor prefers its amine to the hydroxy group in binding to catalytic aspartates. A synchrotron study of HIV-1 protease in complex with a peptidomimetic inhibitor.
Dohnálek J, Hasek J, Dusková J, Petroková H, Hradilek M, Soucek M, Konvalinka J, Brynda J, Sedlácek J, Fábry M. Dohnálek J, et al. Among authors: hradilek m. J Med Chem. 2002 Mar 28;45(7):1432-8. doi: 10.1021/jm010979e. J Med Chem. 2002. PMID: 11906284
20 results