Overgaard MT - Search Results

1

Voltage Gated Calcium Channel Dysregulation May Contribute to Neurological Symptoms in Calmodulinopathies.

Hussey JW, DeMarco E, DiSilvestre D, Brohus M, Busuioc AO, Iversen ED, Jensen HH, Nyegaard M, Overgaard MT, Ben-Johny M, Dick IE. Hussey JW, et al. Among authors: overgaard mt. bioRxiv [Preprint]. 2024 Dec 5:2024.12.02.626503. doi: 10.1101/2024.12.02.626503. bioRxiv. 2024. PMID: 39677635 Free PMC article. Preprint.

2

Human Calmodulin Mutations.

Jensen HH, Brohus M, Nyegaard M, Overgaard MT. Jensen HH, et al. Among authors: overgaard mt. Front Mol Neurosci. 2018 Nov 13;11:396. doi: 10.3389/fnmol.2018.00396. eCollection 2018. Front Mol Neurosci. 2018. PMID: 30483049 Free PMC article.

3

Arrhythmia mutations in calmodulin cause conformational changes that affect interactions with the cardiac voltage-gated calcium channel.

Wang K, Holt C, Lu J, Brohus M, Larsen KT, Overgaard MT, Wimmer R, Van Petegem F. Wang K, et al. Among authors: overgaard mt. Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10556-E10565. doi: 10.1073/pnas.1808733115. Epub 2018 Oct 22. Proc Natl Acad Sci U S A. 2018. PMID: 30348784 Free PMC article.

4

Infanticide vs. inherited cardiac arrhythmias.

Brohus M, Arsov T, Wallace DA, Jensen HH, Nyegaard M, Crotti L, Adamski M, Zhang Y, Field MA, Athanasopoulos V, Baró I, Ribeiro de Oliveira-Mendes BB, Redon R, Charpentier F, Raju H, DiSilvestre D, Wei J, Wang R, Rafehi H, Kaspi A, Bahlo M, Dick IE, Chen SRW, Cook MC, Vinuesa CG, Overgaard MT, Schwartz PJ. Brohus M, et al. Among authors: overgaard mt. Europace. 2021 Mar 8;23(3):441-450. doi: 10.1093/europace/euaa272. Europace. 2021. PMID: 33200177 Free PMC article.

5

The International Calmodulinopathy Registry: recording the diverse phenotypic spectrum of un-CALM hearts.

Nyegaard M, Overgaard MT. Nyegaard M, et al. Among authors: overgaard mt. Eur Heart J. 2019 Sep 14;40(35):2976-2978. doi: 10.1093/eurheartj/ehz463. Eur Heart J. 2019. PMID: 31280324 Free PMC article. No abstract available.

6

Role of Calmodulin in Cardiac Disease: Insights on Genotype and Phenotype.

Schwartz PJ, Crotti L, Nyegaard M, Overgaard MT. Schwartz PJ, et al. Among authors: overgaard mt. Circ Genom Precis Med. 2024 Oct;17(5):e004542. doi: 10.1161/CIRCGEN.124.004542. Epub 2024 Sep 9. Circ Genom Precis Med. 2024. PMID: 39247953 Review.

7

Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca(2+) currents and promote proarrhythmic behavior in ventricular myocytes.

Limpitikul WB, Dick IE, Joshi-Mukherjee R, Overgaard MT, George AL Jr, Yue DT. Limpitikul WB, et al. Among authors: overgaard mt. J Mol Cell Cardiol. 2014 Sep;74:115-24. doi: 10.1016/j.yjmcc.2014.04.022. Epub 2014 May 8. J Mol Cell Cardiol. 2014. PMID: 24816216 Free PMC article.

8

Arrhythmia mutations in calmodulin can disrupt cooperativity of Ca²⁺ binding and cause misfolding.

Wang K, Brohus M, Holt C, Overgaard MT, Wimmer R, Van Petegem F. Wang K, et al. Among authors: overgaard mt. J Physiol. 2020 Mar;598(6):1169-1186. doi: 10.1113/JP279307. Epub 2020 Feb 18. J Physiol. 2020. PMID: 32012279 Free article.

9

Role of cardiac ryanodine receptor calmodulin-binding domains in mediating the action of arrhythmogenic calmodulin N-domain mutation N54I.

Søndergaard MT, Liu Y, Guo W, Wei J, Wang R, Brohus M, Overgaard MT, Chen SRW. Søndergaard MT, et al. Among authors: overgaard mt. FEBS J. 2020 Jun;287(11):2256-2280. doi: 10.1111/febs.15147. Epub 2019 Dec 18. FEBS J. 2020. PMID: 31763755 Free article.

10

Ca²⁺-dependent calmodulin binding to cardiac ryanodine receptor (RyR2) calmodulin-binding domains.

Brohus M, Søndergaard MT, Wayne Chen SR, van Petegem F, Overgaard MT. Brohus M, et al. Among authors: overgaard mt. Biochem J. 2019 Jan 18;476(2):193-209. doi: 10.1042/BCJ20180545. Biochem J. 2019. PMID: 30530841 Free PMC article.

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