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Complementary Effects of Host Defense Peptides Piscidin 1 and Piscidin 3 on DNA and Lipid Membranes: Biophysical Insights into Contrasting Biological Activities.
Hayden RM, Goldberg GK, Ferguson BM, Schoeneck MW, Libardo MD, Mayeux SE, Shrestha A, Bogardus KA, Hammer J, Pryshchep S, Lehman HK, McCormick ML, Blazyk J, Angeles-Boza AM, Fu R, Cotten ML. Hayden RM, et al. Among authors: fu r. J Phys Chem B. 2015 Dec 10;119(49):15235-46. doi: 10.1021/acs.jpcb.5b09685. Epub 2015 Dec 1. J Phys Chem B. 2015. PMID: 26569483
High-resolution structures and orientations of antimicrobial peptides piscidin 1 and piscidin 3 in fluid bilayers reveal tilting, kinking, and bilayer immersion.
Perrin BS Jr, Tian Y, Fu R, Grant CV, Chekmenev EY, Wieczorek WE, Dao AE, Hayden RM, Burzynski CM, Venable RM, Sharma M, Opella SJ, Pastor RW, Cotten ML. Perrin BS Jr, et al. Among authors: fu r. J Am Chem Soc. 2014 Mar 5;136(9):3491-504. doi: 10.1021/ja411119m. Epub 2014 Jan 22. J Am Chem Soc. 2014. PMID: 24410116 Free PMC article.
Structure and Function in Antimicrobial Piscidins: Histidine Position, Directionality of Membrane Insertion, and pH-Dependent Permeabilization.
Mihailescu M, Sorci M, Seckute J, Silin VI, Hammer J, Perrin BS Jr, Hernandez JI, Smajic N, Shrestha A, Bogardus KA, Greenwood AI, Fu R, Blazyk J, Pastor RW, Nicholson LK, Belfort G, Cotten ML. Mihailescu M, et al. Among authors: fu r. J Am Chem Soc. 2019 Jun 26;141(25):9837-9853. doi: 10.1021/jacs.9b00440. Epub 2019 Jun 13. J Am Chem Soc. 2019. PMID: 31144503 Free PMC article.
The host-defense peptide piscidin P1 reorganizes lipid domains in membranes and decreases activation energies in mechanosensitive ion channels.
Comert F, Greenwood A, Maramba J, Acevedo R, Lucas L, Kulasinghe T, Cairns LS, Wen Y, Fu R, Hammer J, Blazyk J, Sukharev S, Cotten ML, Mihailescu M. Comert F, et al. Among authors: fu r. J Biol Chem. 2019 Dec 6;294(49):18557-18570. doi: 10.1074/jbc.RA119.010232. Epub 2019 Oct 16. J Biol Chem. 2019. PMID: 31619519 Free PMC article.
3,579 results