Wang AL - Search Results

1

Hypocrellin A from an ethnic medicinal fungus protects against NLRP3-driven gout in mice by suppressing inflammasome activation.

Yan LJ, Qi S, Wu C, Jin R, Hu C, Wang AL, Wang BL, Yu HW, Wang L, Liu J, Qi ZP, Wang WC, Liu QS. Yan LJ, et al. Among authors: wang al. Acta Pharmacol Sin. 2024 Dec 16. doi: 10.1038/s41401-024-01434-1. Online ahead of print. Acta Pharmacol Sin. 2024. PMID: 39681599

2

Predicting and overcoming resistance to CDK9 inhibitors for cancer therapy.

Hu C, Shen L, Zou F, Wu Y, Wang B, Wang A, Wu C, Wang L, Liu J, Wang W, Liu Q. Hu C, et al. Acta Pharm Sin B. 2023 Sep;13(9):3694-3707. doi: 10.1016/j.apsb.2023.05.026. Epub 2023 May 26. Acta Pharm Sin B. 2023. PMID: 37719386 Free PMC article.

3

Discovery of IHMT-337 as a potent irreversible EZH2 inhibitor targeting CDK4 transcription for malignancies.

Mei H, Wu H, Yang J, Zhou B, Wang A, Hu C, Qi S, Jiang Z, Zou F, Wang B, Liu F, Chen Y, Wang W, Liu J, Liu Q. Mei H, et al. Signal Transduct Target Ther. 2023 Jan 16;8(1):18. doi: 10.1038/s41392-022-01240-3. Signal Transduct Target Ther. 2023. PMID: 36642705 Free PMC article.

4

Discovery of IHMT-MST1-39 as a novel MST1 kinase inhibitor and AMPK activator for the treatment of diabetes mellitus.

Wang J, Qi Z, Wu Y, Wang A, Liu Q, Zou F, Wang B, Qi S, Cao J, Hu C, Shi C, Liang Q, Wang L, Liu J, Wang W, Liu Q. Wang J, et al. Signal Transduct Target Ther. 2023 Apr 5;8(1):143. doi: 10.1038/s41392-023-01352-4. Signal Transduct Target Ther. 2023. PMID: 37015918 Free PMC article.

5

Discovery of a highly potent pan-RAF inhibitor IHMT-RAF-128 for cancer treatment.

Wang A, Liu J, Li X, Zou F, Qi Z, Qi S, Liu Q, Wang Z, Cao J, Jiang Z, Wang B, Ge J, Wang L, Wang W, Liu J, Liu Q. Wang A, et al. Eur J Pharmacol. 2023 Aug 5;952:175752. doi: 10.1016/j.ejphar.2023.175752. Epub 2023 May 8. Eur J Pharmacol. 2023. PMID: 37164118

6

Discovery of Pyrazolo[1,5-a]pyrimidine derivative as a potent and selective PI3Kγ/δ dual inhibitor.

Liang X, Deng M, Zou F, Qi Z, Wang C, Liu J, Liu Q, Wang B, Qi S, Ge J, Yu H, Wang A, Liu Q, Liu J. Liang X, et al. Eur J Med Chem. 2023 Nov 15;260:115768. doi: 10.1016/j.ejmech.2023.115768. Epub 2023 Sep 1. Eur J Med Chem. 2023. PMID: 37683362

7

Discovery of dihydropyridinone derivative as a covalent EZH2 degrader.

Zhou B, Wang B, Zou F, Mei H, Liu Q, Qi S, Wang W, Jin R, Wang A, Chen Y, Liu F, Wang W, Liu J, Liu Q. Zhou B, et al. Eur J Med Chem. 2023 Dec 5;261:115825. doi: 10.1016/j.ejmech.2023.115825. Epub 2023 Oct 2. Eur J Med Chem. 2023. PMID: 37826933

8

Discovery of Pyrazolo[1,5-a]pyridine Derivatives as Potent and Selective PI3Kγ/δ Inhibitors.

Wang C, Zou F, Qi Z, Liu Q, Shen L, Yuan X, Deng M, Wang A, Wang B, Wang L, Liang X, Liu Q, Liu J. Wang C, et al. J Med Chem. 2024 Sep 12;67(17):15199-15219. doi: 10.1021/acs.jmedchem.4c00817. Epub 2024 Aug 20. J Med Chem. 2024. PMID: 39163191

9

Structure-based discovery of IHMT-IDH1-053 as a potent irreversible IDH1 mutant selective inhibitor.

Liang Q, Wang B, Zou F, Guo G, Wang W, Wang W, Liu Q, Shen L, Hu C, Wang W, Wang A, Huang T, He Y, Xia R, Ge J, Liu J, Liu Q. Liang Q, et al. Eur J Med Chem. 2023 Aug 5;256:115411. doi: 10.1016/j.ejmech.2023.115411. Epub 2023 May 12. Eur J Med Chem. 2023. PMID: 37209613

10

A novel PDGFR inhibitor WQ-C-401 prevents pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension.

Huang W, Zhou H, He Y, Wang A, Wang B, Chen Y, Liu C, Wang H, Xie W, Kong H. Huang W, et al. Exp Cell Res. 2024 Aug 1;441(1):114154. doi: 10.1016/j.yexcr.2024.114154. Epub 2024 Jul 10. Exp Cell Res. 2024. PMID: 38996959

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