Hughes JR - Search Results

1

HDAC Inhibitors Can Enhance Radiosensitivity of Head and Neck Cancer Cells Through Suppressing DNA Repair.

Antrobus J, Mackinnon B, Melia E, Hughes JR, Parsons JL. Antrobus J, et al. Among authors: hughes jr. Cancers (Basel). 2024 Dec 7;16(23):4108. doi: 10.3390/cancers16234108. Cancers (Basel). 2024. PMID: 39682293 Free PMC article.

2

Inhibition of key DNA double strand break repair protein kinases enhances radiosensitivity of head and neck cancer cells to X-ray and proton irradiation.

Fabbrizi MR, Doggett TJ, Hughes JR, Melia E, Dufficy ER, Hill RM, Goula A, Phoenix B, Parsons JL. Fabbrizi MR, et al. Among authors: hughes jr. Cell Death Discov. 2024 Jun 12;10(1):282. doi: 10.1038/s41420-024-02059-3. Cell Death Discov. 2024. PMID: 38866739 Free PMC article.

3

Effectiveness of PARP inhibition in enhancing the radiosensitivity of 3D spheroids of head and neck squamous cell carcinoma.

Zhou C, Fabbrizi MR, Hughes JR, Grundy GJ, Parsons JL. Zhou C, et al. Among authors: hughes jr. Front Oncol. 2022 Aug 16;12:940377. doi: 10.3389/fonc.2022.940377. eCollection 2022. Front Oncol. 2022. PMID: 36052247 Free PMC article.

4

Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence.

Fabbrizi MR, Nickson CM, Hughes JR, Robinson EA, Vaidya K, Rubbi CP, Kacperek A, Bryant HE, Helleday T, Parsons JL. Fabbrizi MR, et al. Among authors: hughes jr. Cell Death Dis. 2024 Feb 17;15(2):150. doi: 10.1038/s41419-024-06541-9. Cell Death Dis. 2024. PMID: 38368415 Free PMC article.

5

Autophagy is the main driver of radioresistance of HNSCC cells in mild hypoxia.

Hill RM, Li C, Hughes JR, Rocha S, Grundy GJ, Parsons JL. Hill RM, et al. Among authors: hughes jr. J Cell Mol Med. 2024 Jun;28(12):e18482. doi: 10.1111/jcmm.18482. J Cell Mol Med. 2024. PMID: 38899556 Free PMC article.

6

The E3 Ubiquitin Ligase NEDD4L Targets OGG1 for Ubiquitylation and Modulates the Cellular DNA Damage Response.

Hughes JR, Parsons JL. Hughes JR, et al. Front Cell Dev Biol. 2020 Nov 12;8:607060. doi: 10.3389/fcell.2020.607060. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 33282879 Free PMC article.

7

The Enzyme-Modified Neutral Comet (EMNC) Assay for Complex DNA Damage Detection.

Fabbrizi MR, Hughes JR, Parsons JL. Fabbrizi MR, et al. Among authors: hughes jr. Methods Protoc. 2021 Feb 16;4(1):14. doi: 10.3390/mps4010014. Methods Protoc. 2021. PMID: 33669320 Free PMC article.

8

TRIM26 Maintains Cell Survival in Response to Oxidative Stress through Regulating DNA Glycosylase Stability.

Konis SMR, Hughes JR, Parsons JL. Konis SMR, et al. Among authors: hughes jr. Int J Mol Sci. 2022 Oct 1;23(19):11613. doi: 10.3390/ijms231911613. Int J Mol Sci. 2022. PMID: 36232914 Free PMC article.

9

FLASH Radiotherapy: Current Knowledge and Future Insights Using Proton-Beam Therapy.

Hughes JR, Parsons JL. Hughes JR, et al. Int J Mol Sci. 2020 Sep 5;21(18):6492. doi: 10.3390/ijms21186492. Int J Mol Sci. 2020. PMID: 32899466 Free PMC article. Review.

10

USP9X Is Required to Maintain Cell Survival in Response to High-LET Radiation.

Nickson CM, Fabbrizi MR, Carter RJ, Hughes JR, Kacperek A, Hill MA, Parsons JL. Nickson CM, et al. Among authors: hughes jr. Front Oncol. 2021 Jul 1;11:671431. doi: 10.3389/fonc.2021.671431. eCollection 2021. Front Oncol. 2021. PMID: 34277417 Free PMC article.

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