Jakeman DL - Search Results

1

A novel bis-phosphonyl C-glycoside: the first synthesis of C-(1,6-deoxy-β-D-glucopyranosyl)dimethylphosphonate, a stable bisphosphonate to probe the mechanism of β-phosphoglucomutase.

Ghosh R, Jakeman DL. Ghosh R, et al. Among authors: jakeman dl. Org Biomol Chem. 2024 Dec 17. doi: 10.1039/d4ob01756k. Online ahead of print. Org Biomol Chem. 2024. PMID: 39688113

2

Synthesis of a novel fluorinated phosphonyl C-glycoside, (3-deoxy-3-fluoro-β-d-glucopyranosyl)methylphosphonate, a potential inhibitor of β-phosphoglucomutase.

Carroll-Poehls M, Jakeman DL. Carroll-Poehls M, et al. Among authors: jakeman dl. Carbohydr Res. 2023 Dec;534:108979. doi: 10.1016/j.carres.2023.108979. Epub 2023 Nov 2. Carbohydr Res. 2023. PMID: 37931349

3

Inhibitory Evaluation of αPMM/PGM from Pseudomonas aeruginosa: Chemical Synthesis, Enzyme Kinetics, and Protein Crystallographic Study.

Zhu JS, Stiers KM, Soleimani E, Groves BR, Beamer LJ, Jakeman DL. Zhu JS, et al. Among authors: jakeman dl. J Org Chem. 2019 Aug 2;84(15):9627-9636. doi: 10.1021/acs.joc.9b01305. Epub 2019 Jul 16. J Org Chem. 2019. PMID: 31264865

4

The effect of bisphosphonate acidity on the activity of a thymidylyltransferase.

Beaton SA, Jiang PM, Melong JC, Loranger MW, Mohamady S, Veinot TI, Jakeman DL. Beaton SA, et al. Among authors: jakeman dl. Org Biomol Chem. 2013 Sep 7;11(33):5473-80. doi: 10.1039/c3ob41017j. Org Biomol Chem. 2013. PMID: 23857455

5

Synthesis and antimalarial activity of prodigiosenes.

Marchal E, Smithen DA, Uddin MI, Robertson AW, Jakeman DL, Mollard V, Goodman CD, MacDougall KS, McFarland SA, McFadden GI, Thompson A. Marchal E, et al. Among authors: jakeman dl. Org Biomol Chem. 2014 Jun 28;12(24):4132-42. doi: 10.1039/c3ob42548g. Org Biomol Chem. 2014. PMID: 24834447

6

Polyphosphate-containing bisubstrate analogues as inhibitors of a bacterial cell wall thymidylyltransferase.

Smithen DA, Forget SM, McCormick NE, Syvitski RT, Jakeman DL. Smithen DA, et al. Among authors: jakeman dl. Org Biomol Chem. 2015 Mar 21;13(11):3347-50. doi: 10.1039/c4ob02583k. Org Biomol Chem. 2015. PMID: 25655582

7

Synthesis and evaluation of l-rhamnose 1C-phosphonates as nucleotidylyltransferase inhibitors.

Loranger MW, Forget SM, McCormick NE, Syvitski RT, Jakeman DL. Loranger MW, et al. Among authors: jakeman dl. J Org Chem. 2013 Oct 4;78(19):9822-33. doi: 10.1021/jo401542s. Epub 2013 Sep 10. J Org Chem. 2013. PMID: 24020932

8

Kinetic evaluation of glucose 1-phosphate analogues with a thymidylyltransferase using a continuous coupled enzyme assay.

Forget SM, Jee A, Smithen DA, Jagdhane R, Anjum S, Beaton SA, Palmer DR, Syvitski RT, Jakeman DL. Forget SM, et al. Among authors: jakeman dl. Org Biomol Chem. 2015 Jan 21;13(3):866-75. doi: 10.1039/c4ob02057j. Org Biomol Chem. 2015. PMID: 25408103

9

Synthesis of α-Deoxymono and Difluorohexopyranosyl 1-Phosphates and Kinetic Evaluation with Thymidylyl- and Guanidylyltransferases.

Zhu JS, McCormick NE, Timmons SC, Jakeman DL. Zhu JS, et al. Among authors: jakeman dl. J Org Chem. 2016 Oct 7;81(19):8816-8825. doi: 10.1021/acs.joc.6b01485. Epub 2016 Sep 12. J Org Chem. 2016. PMID: 27576508

10

Biosynthetic 4,6-dehydratase gene deletion: isolation of a glucosylated jadomycin natural product provides insight into the substrate specificity of glycosyltransferase JadS.

Forget SM, Na J, McCormick NE, Jakeman DL. Forget SM, et al. Among authors: jakeman dl. Org Biomol Chem. 2017 Mar 28;15(13):2725-2729. doi: 10.1039/c7ob00259a. Org Biomol Chem. 2017. PMID: 28291274

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