Dohnálek J - Search Results

1

4-Oxo-β-lactams as Covalent Inhibitors of the Mitochondrial Intramembrane Protease PARL.

Ji S, Bach K, Miriyala VM, Dohnálek J, Riopedre-Fernandez M, Lepšík M, van de Plassche M, Vanhoutte R, Barniol-Xicota M, Moreira R, Strisovsky K, Verhelst SHL. Ji S, et al. Among authors: dohnalek j. ACS Med Chem Lett. 2024 Nov 14;15(12):2101-2106. doi: 10.1021/acsmedchemlett.4c00384. eCollection 2024 Dec 12. ACS Med Chem Lett. 2024. PMID: 39691509

2

Extensive targeting of chemical space at the prime side of ketoamide inhibitors of rhomboid proteases by branched substituents empowers their selectivity and potency.

Bach K, Dohnálek J, Škerlová J, Kuzmík J, Poláchová E, Stanchev S, Majer P, Fanfrlík J, Pecina A, Řezáč J, Lepšík M, Borshchevskiy V, Polovinkin V, Strisovsky K. Bach K, et al. Among authors: dohnalek j. Eur J Med Chem. 2024 Sep 5;275:116606. doi: 10.1016/j.ejmech.2024.116606. Epub 2024 Jun 17. Eur J Med Chem. 2024. PMID: 38901105 Free article.

3

Membrane Protein Dimerization in Cell-Derived Lipid Membranes Measured by FRET with MC Simulations.

Škerle J, Humpolíčková J, Johnson N, Rampírová P, Poláchová E, Fliegl M, Dohnálek J, Suchánková A, Jakubec D, Strisovsky K. Škerle J, et al. Among authors: dohnalek j. Biophys J. 2020 Apr 21;118(8):1861-1875. doi: 10.1016/j.bpj.2020.03.011. Epub 2020 Mar 29. Biophys J. 2020. PMID: 32246901 Free PMC article.

4

HIV-1 protease mutations and inhibitor modifications monitored on a series of complexes. Structural basis for the effect of the A71V mutation on the active site.

Skalova T, Dohnalek J, Duskova J, Petrokova H, Hradílek M, Soucek M, Konvalinka J, Hasek J. Skalova T, et al. Among authors: dohnalek j. J Med Chem. 2006 Sep 21;49(19):5777-84. doi: 10.1021/jm0605583. J Med Chem. 2006. PMID: 16970402

5

Hydroxyethylamine isostere of an HIV-1 protease inhibitor prefers its amine to the hydroxy group in binding to catalytic aspartates. A synchrotron study of HIV-1 protease in complex with a peptidomimetic inhibitor.

Dohnálek J, Hasek J, Dusková J, Petroková H, Hradilek M, Soucek M, Konvalinka J, Brynda J, Sedlácek J, Fábry M. Dohnálek J, et al. J Med Chem. 2002 Mar 28;45(7):1432-8. doi: 10.1021/jm010979e. J Med Chem. 2002. PMID: 11906284

6

An ethylenamine inhibitor binds tightly to both wild type and mutant HIV-1 proteases. Structure and energy study.

Skálová T, Hasek J, Dohnálek J, Petroková H, Buchtelová E, Dusková J, Soucek M, Majer P, Uhlíková T, Konvalinka J. Skálová T, et al. Among authors: dohnalek j. J Med Chem. 2003 Apr 24;46(9):1636-44. doi: 10.1021/jm021079g. J Med Chem. 2003. PMID: 12699382

7

A highly active S1-P1 nuclease from the opportunistic pathogen Stenotrophomonas maltophilia cleaves c-di-GMP.

Husťáková B, Trundová M, Adámková K, Kovaľ T, Dušková J, Dohnálek J. Husťáková B, et al. Among authors: dohnalek j. FEBS Lett. 2023 Aug;597(16):2103-2118. doi: 10.1002/1873-3468.14683. Epub 2023 Jun 19. FEBS Lett. 2023. PMID: 37309731 Free article.

8

Peptidomimetic inhibitors complexed with HIV-1 protease: crystallisation for X-ray diffraction studies.

Dohnálek J, Hasek J, Brynda J, Fábry M, Sedlácek J, Konvalinka J, Hradilek M, Soucek M, Adams MJ, Naylor CE. Dohnálek J, et al. Gen Physiol Biophys. 1998 Jun;17 Suppl 1:9-11. Gen Physiol Biophys. 1998. PMID: 9789742 No abstract available.

9

Role of hydroxyl group and R/S configuration of isostere in binding properties of HIV-1 protease inhibitors.

Petroková H, Dusková J, Dohnálek J, Skálová T, Vondrácková-Buchtelová E, Soucek M, Konvalinka J, Brynda J, Fábry M, Sedlácek J, Hasek J. Petroková H, et al. Among authors: dohnalek j. Eur J Biochem. 2004 Nov;271(22):4451-61. doi: 10.1111/j.1432-1033.2004.04384.x. Eur J Biochem. 2004. PMID: 15560786 Free article.

10

Substrate preference, RNA binding and active site versatility of Stenotrophomonas maltophilia nuclease SmNuc1, explained by a structural study.

Adámková K, Trundová M, Kovaľ T, Husťáková B, Kolenko P, Dušková J, Skálová T, Dohnálek J. Adámková K, et al. Among authors: dohnalek j. FEBS J. 2025 Jan;292(1):129-152. doi: 10.1111/febs.17265. Epub 2024 Oct 3. FEBS J. 2025. PMID: 39361520 Free PMC article.

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