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Page 1
An antibiotic that mediates immune destruction of senescent cancer cells.
Casagrande Raffi G, Chen J, Feng X, Chen Z, Lieftink C, Deng S, Mo J, Zeng C, Steur M, Wang J, Bleijerveld OB, Hoekman L, van der Wel N, Wang F, Beijersbergen R, Zheng J, Bernards R, Wang L. Casagrande Raffi G, et al. Among authors: hoekman l. Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2417724121. doi: 10.1073/pnas.2417724121. Epub 2024 Dec 18. Proc Natl Acad Sci U S A. 2024. PMID: 39693343
P-stalk ribosomes act as master regulators of cytokine-mediated processes.
Dopler A, Alkan F, Malka Y, van der Kammen R, Hoefakker K, Taranto D, Kocabay N, Mimpen I, Ramirez C, Malzer E, Isaeva OI, Kerkhoff M, Gangaev A, Silva J, Ramalho S, Hoekman L, Altelaar M, Beijersbergen R, Akkari L, Yewdell JW, Kvistborg P, Faller WJ. Dopler A, et al. Among authors: hoekman l. Cell. 2024 Nov 27;187(24):6981-6993.e23. doi: 10.1016/j.cell.2024.09.039. Epub 2024 Oct 21. Cell. 2024. PMID: 39437780 Free article.
UBE2D3 facilitates NHEJ by orchestrating ATM signalling through multi-level control of RNF168.
Yalçin Z, Lam SY, Peuscher MH, van der Torre J, Zhu S, Iyengar PV, Salas-Lloret D, de Krijger I, Moatti N, van der Lugt R, Falcone M, Cerutti A, Bleijerveld OB, Hoekman L, González-Prieto R, Jacobs JJL. Yalçin Z, et al. Among authors: hoekman l. Nat Commun. 2024 Jun 12;15(1):5032. doi: 10.1038/s41467-024-49431-6. Nat Commun. 2024. PMID: 38866770 Free PMC article.
Caskin2 is a novel talin- and Abi1-binding protein that promotes cell motility.
Wang W, Atherton P, Kreft M, Te Molder L, van der Poel S, Hoekman L, Celie P, Joosten RP, Fässler R, Perrakis A, Sonnenberg A. Wang W, et al. Among authors: hoekman l. J Cell Sci. 2024 May 1;137(9):jcs262116. doi: 10.1242/jcs.262116. Epub 2024 May 16. J Cell Sci. 2024. PMID: 38587458 Free PMC article.
Multimodal stimulation screens reveal unique and shared genes limiting T cell fitness.
Lin CP, Levy PL, Alflen A, Apriamashvili G, Ligtenberg MA, Vredevoogd DW, Bleijerveld OB, Alkan F, Malka Y, Hoekman L, Markovits E, George A, Traets JJH, Krijgsman O, van Vliet A, Poźniak J, Pulido-Vicuña CA, de Bruijn B, van Hal-van Veen SE, Boshuizen J, van der Helm PW, Díaz-Gómez J, Warda H, Behrens LM, Mardesic P, Dehni B, Visser NL, Marine JC, Markel G, Faller WJ, Altelaar M, Agami R, Besser MJ, Peeper DS. Lin CP, et al. Among authors: hoekman l. Cancer Cell. 2024 Apr 8;42(4):623-645.e10. doi: 10.1016/j.ccell.2024.02.016. Epub 2024 Mar 14. Cancer Cell. 2024. PMID: 38490212 Free PMC article.
Locus-specific proteome decoding reveals Fpt1 as a chromatin-associated negative regulator of RNA polymerase III assembly.
van Breugel ME, van Kruijsbergen I, Mittal C, Lieftink C, Brouwer I, van den Brand T, Kluin RJC, Hoekman L, Menezes RX, van Welsem T, Del Cortona A, Malik M, Beijersbergen RL, Lenstra TL, Verstrepen KJ, Pugh BF, van Leeuwen F. van Breugel ME, et al. Among authors: hoekman l. Mol Cell. 2023 Dec 7;83(23):4205-4221.e9. doi: 10.1016/j.molcel.2023.10.037. Epub 2023 Nov 22. Mol Cell. 2023. PMID: 37995691 Free PMC article.
Luminal breast cancer identity is determined by loss of glucocorticoid receptor activity.
Prekovic S, Chalkiadakis T, Roest M, Roden D, Lutz C, Schuurman K, Opdam M, Hoekman L, Abbott N, Tesselaar T, Wajahat M, Dwyer AR, Mayayo-Peralta I, Gomez G, Altelaar M, Beijersbergen R, Győrffy B, Young L, Linn S, Jonkers J, Tilley W, Hickey T, Vareslija D, Swarbrick A, Zwart W. Prekovic S, et al. Among authors: hoekman l. EMBO Mol Med. 2023 Dec 7;15(12):e17737. doi: 10.15252/emmm.202317737. Epub 2023 Oct 30. EMBO Mol Med. 2023. PMID: 37902007 Free PMC article.
MYC is a clinically significant driver of mTOR inhibitor resistance in breast cancer.
Bhin J, Yemelyanenko J, Chao X, Klarenbeek S, Opdam M, Malka Y, Hoekman L, Kruger D, Bleijerveld O, Brambillasca CS, Sprengers J, Siteur B, Annunziato S, van Haren MJ, Martin NI, van de Ven M, Peters D, Agami R, Linn SC, Boven E, Altelaar M, Jonkers J, Zingg D, Wessels LFA. Bhin J, et al. Among authors: hoekman l. J Exp Med. 2023 Nov 6;220(11):e20211743. doi: 10.1084/jem.20211743. Epub 2023 Aug 29. J Exp Med. 2023. PMID: 37642941 Free PMC article.
A genome-wide CRISPR screen in human prostate cancer cells reveals drivers of macrophage-mediated cell killing and positions AR as a tumor-intrinsic immunomodulator.
Zaalberg A, Minnee E, Mayayo-Peralta I, Schuurman K, Gregoricchio S, van Schaik TA, Hoekman L, Li D, Corey E, Janssen H, Lieftink C, Prekovic S, Altelaar M, Nelson PS, Beijersbergen RL, Zwart W, Bergman A. Zaalberg A, et al. Among authors: hoekman l. bioRxiv [Preprint]. 2023 Jun 7:2023.06.06.543873. doi: 10.1101/2023.06.06.543873. bioRxiv. 2023. PMID: 37333335 Free PMC article. Preprint.
28 results