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SMURF1 and SMURF2 directly target GLI1 for ubiquitination and proteasome-dependent degradation.
Bordin F, Terriaca G, Apostolico A, Di Fiore A, Mir FT, Bellardinelli S, Bufalieri F, Bordone R, Bellardinilli F, Giannini G, Canettieri G, Di Marcotullio L, Ferretti E, Moretti M, De Smaele E. Bordin F, et al. Among authors: bufalieri f. Cell Death Discov. 2024 Dec 18;10(1):498. doi: 10.1038/s41420-024-02260-4. Cell Death Discov. 2024. PMID: 39695131 Free PMC article.
MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation.
Bordone R, Ivy DM, D'Amico R, Barba M, Gaggianesi M, Di Pastena F, Cesaro B, Bufalieri F, Balzerano A, De Smaele E, Giannini G, Di Marcotullio L, Fatica A, Stassi G, Di Magno L, Coni S, Canettieri G. Bordone R, et al. Among authors: bufalieri f. Oncogene. 2024 Nov;43(46):3349-3365. doi: 10.1038/s41388-024-03170-6. Epub 2024 Sep 22. Oncogene. 2024. PMID: 39306615
SALL4 is a CRL3REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma.
Lospinoso Severini L, Loricchio E, Navacci S, Basili I, Alfonsi R, Bernardi F, Moretti M, Conenna M, Cucinotta A, Coni S, Petroni M, De Smaele E, Giannini G, Maroder M, Canettieri G, Mastronuzzi A, Guardavaccaro D, Ayrault O, Infante P, Bufalieri F, Di Marcotullio L. Lospinoso Severini L, et al. Among authors: bufalieri f. Cell Death Differ. 2024 Feb;31(2):170-187. doi: 10.1038/s41418-023-01246-6. Epub 2023 Dec 7. Cell Death Differ. 2024. PMID: 38062245 Free PMC article.
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation.
Coni S, Bordone R, Ivy DM, Yurtsever ZN, Di Magno L, D'Amico R, Cesaro B, Fatica A, Belardinilli F, Bufalieri F, Maroder M, De Smaele E, Di Marcotullio L, Giannini G, Agostinelli E, Canettieri G. Coni S, et al. Among authors: bufalieri f. Cancer Lett. 2023 Apr 10;559:216120. doi: 10.1016/j.canlet.2023.216120. Epub 2023 Mar 8. Cancer Lett. 2023. PMID: 36893894 Free article.
A gene dosage-dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH-medulloblastoma.
Petroni M, Fabretti F, Di Giulio S, Nicolis di Robilant V, La Monica V, Moretti M, Belardinilli F, Bufalieri F, Coppa A, Paci P, Corsi A, De Smaele E, Coni S, Canettieri G, Di Marcotullio L, Wang ZQ, Giannini G. Petroni M, et al. Among authors: bufalieri f. Neuropathol Appl Neurobiol. 2022 Oct;48(6):e12837. doi: 10.1111/nan.12837. Epub 2022 Aug 10. Neuropathol Appl Neurobiol. 2022. PMID: 35839783 Free PMC article.
Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma.
Infante P, Malfanti A, Quaglio D, Balducci S, De Martin S, Bufalieri F, Mastrotto F, Basili I, Garofalo M, Lospinoso Severini L, Mori M, Manni I, Moretti M, Nicoletti C, Piaggio G, Caliceti P, Botta B, Ghirga F, Salmaso S, Di Marcotullio L. Infante P, et al. Among authors: bufalieri f. Cancer Lett. 2021 Feb 28;499:220-231. doi: 10.1016/j.canlet.2020.11.028. Epub 2020 Nov 26. Cancer Lett. 2021. PMID: 33249196 Free article.
The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma.
Lospinoso Severini L, Ghirga F, Bufalieri F, Quaglio D, Infante P, Di Marcotullio L. Lospinoso Severini L, et al. Among authors: bufalieri f. Expert Opin Ther Targets. 2020 Nov;24(11):1159-1181. doi: 10.1080/14728222.2020.1823967. Epub 2020 Sep 29. Expert Opin Ther Targets. 2020. PMID: 32990091 Review.
22 results