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301 results

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Intestinal E. coli-produced yersiniabactin promotes profibrotic macrophages in Crohn's disease.
Ahn JH, da Silva Pedrosa M, Lopez LR, Tibbs TN, Jeyachandran JN, Vignieri EE, Rothemich A, Cumming I, Irmscher AD, Haswell CJ, Zamboni WC, Yu YA, Ellermann M, Denson LA, Arthur JC. Ahn JH, et al. Among authors: denson la. Cell Host Microbe. 2025 Jan 8;33(1):71-88.e9. doi: 10.1016/j.chom.2024.11.012. Epub 2024 Dec 18. Cell Host Microbe. 2025. PMID: 39701098 Free article.
Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem Cells.
Tominaga K, Kechele DO, Sanchez JG, Vales S, Jurickova I, Roman L, Asai A, Enriquez JR, McCauley HA, Kishimoto K, Iwasawa K, Singh A, Horio Y, Múnera JO, Takebe T, Zorn AM, Helmrath MA, Denson LA, Wells JM. Tominaga K, et al. Among authors: denson la. Cell Mol Gastroenterol Hepatol. 2024 Dec 17:101444. doi: 10.1016/j.jcmgh.2024.101444. Online ahead of print. Cell Mol Gastroenterol Hepatol. 2024. PMID: 39701210 Free article.
Environmental Factors Associated With Risk of Crohn's Disease Development in the Crohn's and Colitis Canada - Genetic, Environmental, Microbial Project.
Xue M, Leibovitzh H, Jingcheng S, Neustaeter A, Dong M, Xu W, Espin-Garcia O, Griffiths AM, Steinhart AH, Turner D, Huynh HQ, Dieleman LA, Panaccione R, Aumais G, Bressler B, Bitton A, Murthy S, Marshall JK, Hyams JS, Otley A, Bernstein CN, Moayyedi P, El-Matary W, Fich A, Denson LA, Ropeleski MJ, Abreu MT, Deslandres C, Cino M, Avni-Biron I, Lee SH, Turpin W; CCC GEM Project Research Consortium; Croitoru K. Xue M, et al. Among authors: denson la. Clin Gastroenterol Hepatol. 2024 Sep;22(9):1889-1897.e12. doi: 10.1016/j.cgh.2024.03.049. Epub 2024 May 16. Clin Gastroenterol Hepatol. 2024. PMID: 38759825
STARD7 maintains intestinal epithelial mitochondria architecture, barrier integrity, and protection from colitis.
Uddin J, Sharma A, Wu D, Tomar S, Ganesan V, Reichel PE, Thota LNR, Cabrera-Silva RI, Marella S, Idelman G, Tay HL, Raya-Sandino A, Reynolds MB, Elesela S, Haberman Y, Denson LA, Parkos CA, O'Riordan MX, Lukacs NW, O'Dwyer DN, Divanovic S, Nusrat A, Weaver TE, Hogan SP. Uddin J, et al. Among authors: denson la. JCI Insight. 2024 Nov 22;9(22):e172978. doi: 10.1172/jci.insight.172978. JCI Insight. 2024. PMID: 39576011 Free PMC article.
Genetic coding variant in complement factor B (CFB) is associated with increased risk for perianal Crohn's disease and leads to impaired CFB cleavage and phagocytosis.
Akhlaghpour M, Haritunians T, More SK, Thomas LS, Stamps DT, Dube S, Li D, Yang S, Landers CJ, Mengesha E, Hamade H, Murali R, Potdar AA, Wolf AJ, Botwin GJ, Khrom M; International IBD Genetics Consortium; Ananthakrishnan AN, Faubion WA, Jabri B, Lira SA, Newberry RD, Sandler RS, Sartor RB, Xavier RJ, Brant SR, Cho JH, Duerr RH, Lazarev MG, Rioux JD, Schumm LP, Silverberg MS, Zaghiyan K, Fleshner P, Melmed GY, Vasiliauskas EA, Ha C, Rabizadeh S, Syal G, Bonthala NN, Ziring DA, Targan SR, Long MD, McGovern DPB, Michelsen KS. Akhlaghpour M, et al. Gut. 2023 Nov;72(11):2068-2080. doi: 10.1136/gutjnl-2023-329689. Epub 2023 Apr 20. Gut. 2023. PMID: 37080587 Free PMC article.
Increased Intestinal Permeability Is Associated With Later Development of Crohn's Disease.
Turpin W, Lee SH, Raygoza Garay JA, Madsen KL, Meddings JB, Bedrani L, Power N, Espin-Garcia O, Xu W, Smith MI, Griffiths AM, Moayyedi P, Turner D, Seidman EG, Steinhart AH, Marshall JK, Jacobson K, Mack D, Huynh H, Bernstein CN, Paterson AD; Crohn’s and Colitis Canada Genetic Environmental Microbial Project Research Consortium; CCC GEM Project recruitment site directors include Maria Abreu; Croitoru K. Turpin W, et al. Gastroenterology. 2020 Dec;159(6):2092-2100.e5. doi: 10.1053/j.gastro.2020.08.005. Epub 2020 Aug 10. Gastroenterology. 2020. PMID: 32791132
301 results