Tsai JY - Search Results

1

Discovery and biological evaluation of potent 2-trifluoromethyl acrylamide warhead-containing inhibitors of protein disulfide isomerase.

Chu JC, Tsai KC, Wang TY, Chen TY, Tsai JY, Lee T, Lin MH, Hsieh YSY, Wu CC, Huang WJ. Chu JC, et al. Among authors: tsai jy. Eur J Med Chem. 2025 Feb 5;283:117169. doi: 10.1016/j.ejmech.2024.117169. Epub 2024 Dec 16. Eur J Med Chem. 2025. PMID: 39708767

2

Discovery of 5-Hydroxy-1,4-naphthoquinone (Juglone) Derivatives as Dual Effective Agents Targeting Platelet-Cancer Interplay through Protein Disulfide Isomerase Inhibition.

Juang YP, Tsai JY, Gu WL, Hsu HC, Lin CL, Wu CC, Liang PH. Juang YP, et al. Among authors: tsai jy. J Med Chem. 2024 Mar 14;67(5):3626-3642. doi: 10.1021/acs.jmedchem.3c02107. Epub 2024 Feb 21. J Med Chem. 2024. PMID: 38381886 Free PMC article.

3

The chemopreventive isothiocyanate sulforaphane reduces anoikis resistance and anchorage-independent growth in non-small cell human lung cancer cells.

Tsai JY, Tsai SH, Wu CC. Tsai JY, et al. Among authors: tsai sh. Toxicol Appl Pharmacol. 2019 Jan 1;362:116-124. doi: 10.1016/j.taap.2018.10.020. Epub 2018 Oct 24. Toxicol Appl Pharmacol. 2019. PMID: 30365975

4

Discovery of 7, 4'-dimethoxy-3-hydroxyflavone as a protease-activated receptor 4 antagonist with antithrombotic activity and less bleeding tendency in mice.

Lin YT, Li Y, Hsu HC, Tsai JY, Lee JH, Tai CJ, Wu MJ, Wu CC. Lin YT, et al. Among authors: tsai jy. Biochem Pharmacol. 2022 Aug;202:115152. doi: 10.1016/j.bcp.2022.115152. Epub 2022 Jun 22. Biochem Pharmacol. 2022. PMID: 35752281

5

Isolation of Phorbol Esters from Euphorbia grandicornis and Evaluation of Protein Kinase C- and Human Platelet-Activating Effects of Euphorbiaceae Diterpenes.

Tsai JY, Rédei D, Forgo P, Li Y, Vasas A, Hohmann J, Wu CC. Tsai JY, et al. J Nat Prod. 2016 Oct 28;79(10):2658-2666. doi: 10.1021/acs.jnatprod.6b00603. Epub 2016 Oct 12. J Nat Prod. 2016. PMID: 27731641

6

Golden berry 4β-hydroxywithanolide E prevents tumor necrosis factor α-induced procoagulant activity with enhanced cytotoxicity against human lung cancer cells.

Hsieh KY, Tsai JY, Lin YH, Chang FR, Wang HC, Wu CC. Hsieh KY, et al. Among authors: tsai jy. Sci Rep. 2021 Feb 25;11(1):4610. doi: 10.1038/s41598-021-84207-8. Sci Rep. 2021. PMID: 33633307 Free PMC article.

7

12-Deoxyphorbol Esters Induce Growth Arrest and Apoptosis in Human Lung Cancer A549 Cells Via Activation of PKC-δ/PKD/ERK Signaling Pathway.

Tsai JY, Rédei D, Hohmann J, Wu CC. Tsai JY, et al. Int J Mol Sci. 2020 Oct 14;21(20):7579. doi: 10.3390/ijms21207579. Int J Mol Sci. 2020. PMID: 33066446 Free PMC article.

8

Different effects of 4β-hydroxywithanolide E and withaferin A, two withanolides from Solanaceae plants, on the Akt signaling pathway in human breast cancer cells.

Wang HC, Hu HH, Chang FR, Tsai JY, Kuo CY, Wu YC, Wu CC. Wang HC, et al. Among authors: tsai jy. Phytomedicine. 2019 Feb;53:213-222. doi: 10.1016/j.phymed.2018.09.017. Epub 2018 Sep 5. Phytomedicine. 2019. PMID: 30668401

9

Selective Inhibition of PAR4 (Protease-Activated Receptor 4)-Mediated Platelet Activation by a Synthetic Nonanticoagulant Heparin Analog.

Lin YC, Ko YC, Hung SC, Lin YT, Lee JH, Tsai JY, Kung PH, Tsai MC, Chen YF, Wu CC. Lin YC, et al. Among authors: tsai mc, tsai jy. Arterioscler Thromb Vasc Biol. 2019 Apr;39(4):694-703. doi: 10.1161/ATVBAHA.118.311758. Arterioscler Thromb Vasc Biol. 2019. PMID: 30727756 Free article.

10

Repeated administration of pharmaceutical-grade medium chain triglycerides, a common pharmacologic excipient, confers dose-dependent toxicity by the intraperitoneal but not oral route in mice.

Adler-Wachter M, Tsai JY, Schweitzer BN, McDonough A, Snyder JM, Barker-Haliski M, Weinstein JR. Adler-Wachter M, et al. Among authors: tsai jy. bioRxiv [Preprint]. 2024 Nov 26:2024.11.24.625115. doi: 10.1101/2024.11.24.625115. bioRxiv. 2024. PMID: 39651141 Free PMC article. Preprint.

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