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Page 1
snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses.
Macnair W, Calini D, Agirre E, Bryois J, Jäkel S, Smith RS, Kukanja P, Stokar-Regenscheit N, Ott V, Foo LC, Collin L, Schippling S, Urich E, Nutma E, Marzin M, Ansaloni F, Amor S, Magliozzi R, Heidari E, Robinson MD, Ffrench-Constant C, Castelo-Branco G, Williams A, Malhotra D. Macnair W, et al. Among authors: nutma e. Neuron. 2024 Dec 19:S0896-6273(24)00873-0. doi: 10.1016/j.neuron.2024.11.016. Online ahead of print. Neuron. 2024. PMID: 39708806
Human post-mortem organotypic brain slice cultures: a tool to study pathomechanisms and test therapies.
Plug BC, Revers IM, Breur M, González GM, Timmerman JA, Meijns NRC, Hamberg D, Wagendorp J, Nutma E, Wolf NI, Luchicchi A, Mansvelder HD, van Til NP, van der Knaap MS, Bugiani M. Plug BC, et al. Among authors: nutma e. Acta Neuropathol Commun. 2024 May 31;12(1):83. doi: 10.1186/s40478-024-01784-1. Acta Neuropathol Commun. 2024. PMID: 38822428 Free PMC article.
Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases.
Nutma E, Fancy N, Weinert M, Tsartsalis S, Marzin MC, Muirhead RCJ, Falk I, Breur M, de Bruin J, Hollaus D, Pieterman R, Anink J, Story D, Chandran S, Tang J, Trolese MC, Saito T, Saido TC, Wiltshire KH, Beltran-Lobo P, Phillips A, Antel J, Healy L, Dorion MF, Galloway DA, Benoit RY, Amossé Q, Ceyzériat K, Badina AM, Kövari E, Bendotti C, Aronica E, Radulescu CI, Wong JH, Barron AM, Smith AM, Barnes SJ, Hampton DW, van der Valk P, Jacobson S, Howell OW, Baker D, Kipp M, Kaddatz H, Tournier BB, Millet P, Matthews PM, Moore CS, Amor S, Owen DR. Nutma E, et al. Nat Commun. 2023 Aug 28;14(1):5247. doi: 10.1038/s41467-023-40937-z. Nat Commun. 2023. PMID: 37640701 Free PMC article.
Longitudinal positron emission tomography and postmortem analysis reveals widespread neuroinflammation in SARS-CoV-2 infected rhesus macaques.
Nieuwland JM, Nutma E, Philippens IHCHM, Böszörményi KP, Remarque EJ, Bakker J, Meijer L, Woerdman N, Fagrouch ZC, Verstrepen BE, Langermans JAM, Verschoor EJ, Windhorst AD, Bontrop RE, de Vries HE, Stammes MA, Middeldorp J. Nieuwland JM, et al. Among authors: nutma e. J Neuroinflammation. 2023 Jul 29;20(1):179. doi: 10.1186/s12974-023-02857-z. J Neuroinflammation. 2023. PMID: 37516868 Free PMC article.
Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders.
Bryois J, Calini D, Macnair W, Foo L, Urich E, Ortmann W, Iglesias VA, Selvaraj S, Nutma E, Marzin M, Amor S, Williams A, Castelo-Branco G, Menon V, De Jager P, Malhotra D. Bryois J, et al. Among authors: nutma e. Nat Neurosci. 2022 Aug;25(8):1104-1112. doi: 10.1038/s41593-022-01128-z. Epub 2022 Aug 1. Nat Neurosci. 2022. PMID: 35915177
Immunopathology of the optic nerve in multiple sclerosis.
Fernández Blanco L, Marzin M, Leistra A, van der Valk P, Nutma E, Amor S. Fernández Blanco L, et al. Among authors: nutma e. Clin Exp Immunol. 2022 Aug 19;209(2):236-246. doi: 10.1093/cei/uxac063. Clin Exp Immunol. 2022. PMID: 35778909 Free PMC article.
Myeloid cell-specific topoisomerase 1 inhibition using DNA origami mitigates neuroinflammation.
Zhu K, Wang Y, Sarlus H, Geng K, Nutma E, Sun J, Kung SY, Bay C, Han J, Min JH, Benito-Cuesta I, Lund H, Amor S, Wang J, Zhang XM, Kutter C, Guerreiro-Cacais AO, Högberg B, Harris RA. Zhu K, et al. Among authors: nutma e. EMBO Rep. 2022 Jul 5;23(7):e54499. doi: 10.15252/embr.202154499. Epub 2022 May 20. EMBO Rep. 2022. PMID: 35593064 Free PMC article.
Transmembrane protein 119 is neither a specific nor a reliable marker for microglia.
Vankriekelsvenne E, Chrzanowski U, Manzhula K, Greiner T, Wree A, Hawlitschka A, Llovera G, Zhan J, Joost S, Schmitz C, Ponsaerts P, Amor S, Nutma E, Kipp M, Kaddatz H. Vankriekelsvenne E, et al. Among authors: nutma e. Glia. 2022 Jun;70(6):1170-1190. doi: 10.1002/glia.24164. Epub 2022 Mar 4. Glia. 2022. PMID: 35246882
Brain macrophages acquire distinct transcriptomes in multiple sclerosis lesions and normal appearing white matter.
Miedema A, Gerrits E, Brouwer N, Jiang Q, Kracht L, Meijer M, Nutma E, Peferoen-Baert R, Pijnacker ATE, Wesseling EM, Wijering MHC, Gabius HJ, Amor S, Eggen BJL, Kooistra SM. Miedema A, et al. Among authors: nutma e. Acta Neuropathol Commun. 2022 Jan 28;10(1):8. doi: 10.1186/s40478-021-01306-3. Acta Neuropathol Commun. 2022. PMID: 35090578 Free PMC article.
27 results