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Advancing precision therapy for colorectal cancer: Developing clinical indications for multi-target kinase inhibitor BPR1J481 using patient-derived xenograft models.
Tang YC, Ou JJ, Hsu SC, Huang CH, Lin LM, Chang HH, Wang YH, Huang ZT, Sun M, Liu KJ, Hung YM, Lai CY, Shih C, Chen CT, Chang JY, Hsieh HP, Jiaang WT, Kuo CC. Tang YC, et al. Among authors: kuo cc. Pharmacol Res. 2025 Jan;211:107556. doi: 10.1016/j.phrs.2024.107556. Epub 2024 Dec 20. Pharmacol Res. 2025. PMID: 39709137 Free article.
Novel Nrf2/ARE activator, trans-Coniferylaldehyde, induces a HO-1-mediated defense mechanism through a dual p38α/MAPKAPK-2 and PK-N3 signaling pathway.
Chen HH, Wang TC, Lee YC, Shen PT, Chang JY, Yeh TK, Huang CH, Chang HH, Cheng SY, Lin CY, Shih C, Chen CT, Liu WM, Chen CH, Kuo CC. Chen HH, et al. Among authors: kuo cc. Chem Res Toxicol. 2015 Sep 21;28(9):1681-92. doi: 10.1021/acs.chemrestox.5b00085. Epub 2015 Aug 24. Chem Res Toxicol. 2015. PMID: 26275128
Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells.
Chen HH, Chang HH, Chang JY, Tang YC, Cheng YC, Lin LM, Cheng SY, Huang CH, Sun MW, Chen CT, Kuo CC. Chen HH, et al. Among authors: kuo cc. Free Radic Biol Med. 2017 Dec;113:505-518. doi: 10.1016/j.freeradbiomed.2017.10.375. Epub 2017 Nov 5. Free Radic Biol Med. 2017. PMID: 29080842
4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy.
Lin SY, Yeh TK, Song JS, Hung MS, Cheng MF, Liao FY, Li AS, Cheng SY, Lin LM, Chiu CH, Wu MH, Lin YJ, Hsiao W, Sun M, Wang YH, Huang CH, Tang YC, Chang HH, Huang ZT, Chao YS, Shih C, Pan SL, Wu SY, Kuo CC, Ueng SH. Lin SY, et al. Among authors: kuo cc. Bioorg Chem. 2018 Apr;77:600-607. doi: 10.1016/j.bioorg.2018.02.010. Epub 2018 Feb 12. Bioorg Chem. 2018. PMID: 29494816
Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.
Lin WH, Wu SY, Yeh TK, Chen CT, Song JS, Shiao HY, Kuo CC, Hsu T, Lu CT, Wang PC, Wu TS, Peng YH, Lin HY, Chen CP, Weng YL, Kung FC, Wu MH, Su YC, Huang KW, Chou LH, Hsueh CC, Yen KJ, Kuo PC, Huang CL, Chen LT, Shih C, Tsai HJ, Jiaang WT. Lin WH, et al. Among authors: kuo cc, kuo pc. J Med Chem. 2019 Dec 26;62(24):11135-11150. doi: 10.1021/acs.jmedchem.9b01229. Epub 2019 Dec 6. J Med Chem. 2019. PMID: 31721578
1,576 results