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128 results

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Page 1
Tumour purity assessment with deep learning in colorectal cancer and impact on molecular analysis.
Schoenpflug LA, Chatzipli A, Sirinukunwattana K, Richman S, Blake A, Robineau J, Mertz KD, Verrill C, Leedham SJ, Hardy C, Whalley C, Redmond K, Dunne P, Walker S, Beggs AD, McDermott U, Murray GI, Samuel LM, Seymour M, Tomlinson I, Quirke P; S:CORT consortium; Rittscher J, Maughan T, Domingo E, Koelzer VH. Schoenpflug LA, et al. Among authors: koelzer vh. J Pathol. 2025 Feb;265(2):184-197. doi: 10.1002/path.6376. Epub 2024 Dec 22. J Pathol. 2025. PMID: 39710952 Free PMC article.
Image-based consensus molecular subtype (imCMS) classification of colorectal cancer using deep learning.
Sirinukunwattana K, Domingo E, Richman SD, Redmond KL, Blake A, Verrill C, Leedham SJ, Chatzipli A, Hardy C, Whalley CM, Wu CH, Beggs AD, McDermott U, Dunne PD, Meade A, Walker SM, Murray GI, Samuel L, Seymour M, Tomlinson I, Quirke P, Maughan T, Rittscher J, Koelzer VH; S:CORT consortium. Sirinukunwattana K, et al. Among authors: koelzer vh. Gut. 2021 Mar;70(3):544-554. doi: 10.1136/gutjnl-2019-319866. Epub 2020 Jul 20. Gut. 2021. PMID: 32690604 Free PMC article.
Image-based consensus molecular subtyping in rectal cancer biopsies and response to neoadjuvant chemoradiotherapy.
Lafarge MW, Domingo E, Sirinukunwattana K, Wood R, Samuel L, Murray G, Richman SD, Blake A, Sebag-Montefiore D, Gollins S, Klieser E, Neureiter D, Huemer F, Greil R, Dunne P, Quirke P, Weiss L, Rittscher J, Maughan T, Koelzer VH. Lafarge MW, et al. Among authors: koelzer vh. NPJ Precis Oncol. 2024 Apr 9;8(1):89. doi: 10.1038/s41698-024-00580-3. NPJ Precis Oncol. 2024. PMID: 38594327 Free PMC article.
The evolutionary landscape of colorectal tumorigenesis.
Cross W, Kovac M, Mustonen V, Temko D, Davis H, Baker AM, Biswas S, Arnold R, Chegwidden L, Gatenbee C, Anderson AR, Koelzer VH, Martinez P, Jiang X, Domingo E, Woodcock DJ, Feng Y, Kovacova M, Maughan T; S:CORT Consortium; Jansen M, Rodriguez-Justo M, Ashraf S, Guy R, Cunningham C, East JE, Wedge DC, Wang LM, Palles C, Heinimann K, Sottoriva A, Leedham SJ, Graham TA, Tomlinson IPM. Cross W, et al. Among authors: koelzer vh. Nat Ecol Evol. 2018 Oct;2(10):1661-1672. doi: 10.1038/s41559-018-0642-z. Epub 2018 Aug 31. Nat Ecol Evol. 2018. PMID: 30177804 Free PMC article.
Exploiting differential Wnt target gene expression to generate a molecular biomarker for colorectal cancer stratification.
Kleeman SO, Koelzer VH, Jones HJ, Vazquez EG, Davis H, East JE, Arnold R, Koppens MA, Blake A, Domingo E, Cunningham C, Beggs AD, Pestinger V, Loughrey MB, Wang LM, Lannagan TR, Woods SL, Worthley D, Consortium SC, Tomlinson I, Dunne PD, Maughan T, Leedham SJ. Kleeman SO, et al. Among authors: koelzer vh. Gut. 2020 Jun;69(6):1092-1103. doi: 10.1136/gutjnl-2019-319126. Epub 2019 Sep 28. Gut. 2020. PMID: 31563876 Free PMC article.
In-depth Clinical and Biological Exploration of DNA Damage Immune Response as a Biomarker for Oxaliplatin Use in Colorectal Cancer.
Malla SB, Fisher DJ, Domingo E, Blake A, Hassanieh S, Redmond KL, Richman SD, Youdell M, Walker SM, Logan GE, Chatzipli A, Amirkhah R, Humphries MP, Craig SG, McDermott U, Seymour MT, Morton DG, Quirke P, West NP, Salto-Tellez M, Kennedy RD, Johnston PG, Tomlinson I, Koelzer VH, Campo L, Kaplan RS, Longley DB, Lawler M, Maughan TS, Brown LC, Dunne PD; S:CORT consortium. Malla SB, et al. Among authors: koelzer vh. Clin Cancer Res. 2021 Jan 1;27(1):288-300. doi: 10.1158/1078-0432.CCR-20-3237. Epub 2020 Oct 7. Clin Cancer Res. 2021. PMID: 33028592 Free PMC article.
Stratification to Neoadjuvant Radiotherapy in Rectal Cancer by Regimen and Transcriptional Signatures.
Mahmood U, Blake A, Rathee S, Samuel L, Murray G, Sebag-Montefiore D, Gollins S, West NP, Begum R, Bach SP, Richman SD, Quirke P, Redmond KL, Salto-Tellez M, Koelzer VH, Leedham SJ, Tomlinson I, Dunne PD, Buffa FM; S:CORT consortium; Maughan TS, Domingo E. Mahmood U, et al. Among authors: koelzer vh. Cancer Res Commun. 2024 Jul 1;4(7):1765-1776. doi: 10.1158/2767-9764.CRC-23-0502. Cancer Res Commun. 2024. PMID: 39023969 Free PMC article.
Biological Misinterpretation of Transcriptional Signatures in Tumor Samples Can Unknowingly Undermine Mechanistic Understanding and Faithful Alignment with Preclinical Data.
Fisher NC, Byrne RM, Leslie H, Wood C, Legrini A, Cameron AJ, Ahmaderaghi B, Corry SM, Malla SB, Amirkhah R, McCooey AJ, Rogan E, Redmond KL, Sakhnevych S, Domingo E, Jackson J, Loughrey MB, Leedham S, Maughan T, Lawler M, Sansom OJ, Lamrock F, Koelzer VH, Jamieson NB, Dunne PD. Fisher NC, et al. Among authors: koelzer vh. Clin Cancer Res. 2022 Sep 15;28(18):4056-4069. doi: 10.1158/1078-0432.CCR-22-1102. Clin Cancer Res. 2022. PMID: 35792866 Free PMC article.
128 results