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Defining a highly conserved B cell epitope in the receptor binding motif of SARS-CoV-2 spike glycoprotein.
Malladi SK, Jaiswal D, Ying B, Alsoussi WB, Darling TL, Dadonaite B, Civljak A, Horvath SC, Zhou JQ, Kim W, Turner JS, Schmitz AJ, Han F, Scheaffer SM, Farnsworth CW, Nachbagauer R, Nestorova B, Chalkias S, Klebert MK, Edwards DK, Paris R, Strnad BS, Middleton WD, O'Halloran JA, Presti RM, Bloom JD, Boon ACM, Diamond MS, Bajic G, Ellebedy AH. Malladi SK, et al. Among authors: bajic g. bioRxiv [Preprint]. 2024 Dec 9:2024.12.06.625234. doi: 10.1101/2024.12.06.625234. bioRxiv. 2024. PMID: 39713327 Free PMC article. Preprint.
A public vaccine-induced human antibody protects against SARS-CoV-2 and emerging variants.
Schmitz AJ, Turner JS, Liu Z, Aziati ID, Chen RE, Joshi A, Bricker TL, Darling TL, Adelsberg DC, Alsoussi WB, Case JB, Lei T, Thapa M, Amanat F, O'Halloran JA, Shi PY, Presti RM, Krammer F, Bajic G, Whelan SPJ, Diamond MS, Boon ACM, Ellebedy AH. Schmitz AJ, et al. Among authors: bajic g. bioRxiv [Preprint]. 2021 Mar 24:2021.03.24.436864. doi: 10.1101/2021.03.24.436864. bioRxiv. 2021. Update in: Immunity. 2021 Sep 14;54(9):2159-2166.e6. doi: 10.1016/j.immuni.2021.08.013 PMID: 33791696 Free PMC article. Updated. Preprint.
A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants.
Schmitz AJ, Turner JS, Liu Z, Zhou JQ, Aziati ID, Chen RE, Joshi A, Bricker TL, Darling TL, Adelsberg DC, Altomare CG, Alsoussi WB, Case JB, VanBlargan LA, Lei T, Thapa M, Amanat F, Jeevan T, Fabrizio T, O'Halloran JA, Shi PY, Presti RM, Webby RJ, Krammer F, Whelan SPJ, Bajic G, Diamond MS, Boon ACM, Ellebedy AH. Schmitz AJ, et al. Among authors: bajic g. Immunity. 2021 Sep 14;54(9):2159-2166.e6. doi: 10.1016/j.immuni.2021.08.013. Epub 2021 Aug 17. Immunity. 2021. PMID: 34464596 Free PMC article.
The plasmablast response to SARS-CoV-2 mRNA vaccination is dominated by non-neutralizing antibodies and targets both the NTD and the RBD.
Amanat F, Thapa M, Lei T, Sayed Ahmed SM, Adelsberg DC, Carreno JM, Strohmeier S, Schmitz AJ, Zafar S, Zhou JQ, Rijnink W, Alshammary H, Borcherding N, Reiche AG, Srivastava K, Sordillo EM, van Bakel H; Personalized Virology Initiative; Turner JS, Bajic G, Simon V, Ellebedy AH, Krammer F. Amanat F, et al. Among authors: bajic g. medRxiv [Preprint]. 2021 May 1:2021.03.07.21253098. doi: 10.1101/2021.03.07.21253098. medRxiv. 2021. PMID: 33758878 Free PMC article. Preprint.
SARS-CoV-2 mRNA vaccination induces functionally diverse antibodies to NTD, RBD, and S2.
Amanat F, Thapa M, Lei T, Ahmed SMS, Adelsberg DC, Carreño JM, Strohmeier S, Schmitz AJ, Zafar S, Zhou JQ, Rijnink W, Alshammary H, Borcherding N, Reiche AG, Srivastava K, Sordillo EM, van Bakel H; Personalized Virology Initiative; Turner JS, Bajic G, Simon V, Ellebedy AH, Krammer F. Amanat F, et al. Among authors: bajic g. Cell. 2021 Jul 22;184(15):3936-3948.e10. doi: 10.1016/j.cell.2021.06.005. Epub 2021 Jun 8. Cell. 2021. PMID: 34192529 Free PMC article.
Memory B cell repertoire for recognition of evolving SARS-CoV-2 spike.
Tong P, Gautam A, Windsor I, Travers M, Chen Y, Garcia N, Whiteman NB, McKay LGA, Lelis FJN, Habibi S, Cai Y, Rennick LJ, Duprex WP, McCarthy KR, Lavine CL, Zuo T, Lin J, Zuiani A, Feldman J, MacDonald EA, Hauser BM, Griffths A, Seaman MS, Schmidt AG, Chen B, Neuberg D, Bajic G, Harrison SC, Wesemann DR. Tong P, et al. Among authors: bajic g. bioRxiv [Preprint]. 2021 Mar 10:2021.03.10.434840. doi: 10.1101/2021.03.10.434840. bioRxiv. 2021. Update in: Cell. 2021 Sep 16;184(19):4969-4980.e15. doi: 10.1016/j.cell.2021.07.025 PMID: 33758863 Free PMC article. Updated. Preprint.
Naive human B cells engage the receptor binding domain of SARS-CoV-2, variants of concern, and related sarbecoviruses.
Feldman J, Bals J, Altomare CG, St Denis K, Lam EC, Hauser BM, Ronsard L, Sangesland M, Moreno TB, Okonkwo V, Hartojo N, Balazs AB, Bajic G, Lingwood D, Schmidt AG. Feldman J, et al. Among authors: bajic g. bioRxiv [Preprint]. 2021 Jul 9:2021.02.02.429458. doi: 10.1101/2021.02.02.429458. bioRxiv. 2021. Update in: Sci Immunol. 2021 Dec 10;6(66):eabl5842. doi: 10.1126/sciimmunol.abl5842 PMID: 33594359 Free PMC article. Updated. Preprint.
An in vitro experimental pipeline to characterize the binding specificity of SARS-CoV-2 neutralizing antibodies.
Atanasoff KE, Brambilla L, Adelsberg DC, Kowdle S, Stevens CS, Hung CT, Fu Y, Lim R, Tran L, Allen R, Andrew Duty J, Bajic G, Lee B, Tortorella D. Atanasoff KE, et al. Among authors: bajic g. bioRxiv [Preprint]. 2023 Apr 21:2023.04.20.537738. doi: 10.1101/2023.04.20.537738. bioRxiv. 2023. Update in: mBio. 2024 Jan 16;15(1):e0247723. doi: 10.1128/mbio.02477-23 PMID: 37131698 Free PMC article. Updated. Preprint.
Protective effect and molecular mechanisms of human non-neutralizing cross-reactive spike antibodies elicited by SARS-CoV-2 mRNA vaccination.
Clark JJ, Hoxie I, Adelsberg DC, Sapse IA, Andreata-Santos R, Yong JS, Amanat F, Tcheou J, Raskin A, Singh G, González-Domínguez I, Edgar JE, Bournazos S, Sun W, Carreño JM, Simon V, Ellebedy AH, Bajic G, Krammer F. Clark JJ, et al. Among authors: bajic g. Cell Rep. 2024 Nov 26;43(11):114922. doi: 10.1016/j.celrep.2024.114922. Epub 2024 Nov 5. Cell Rep. 2024. PMID: 39504245 Free article.
44 results