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Ethanol self-administration targets GluA2-containing AMPA receptor expression and synaptic activity in the nucleus accumbens in a manner that drives the positive reinforcing properties of the drug.
Faccidomo S, Saunders BL, May AM, Eastman VR, Kim M, Taylor SM, Hoffman JL, McElligott ZA, Hodge CW. Faccidomo S, et al. Psychopharmacology (Berl). 2024 Dec 23. doi: 10.1007/s00213-024-06740-4. Online ahead of print. Psychopharmacology (Berl). 2024. PMID: 39714485
Operant ethanol self-administration increases extracellular-signal regulated protein kinase (ERK) phosphorylation in reward-related brain regions: selective regulation of positive reinforcement in the prefrontal cortex of C57BL/6J mice.
Faccidomo S, Salling MC, Galunas C, Hodge CW. Faccidomo S, et al. Psychopharmacology (Berl). 2015 Sep;232(18):3417-30. doi: 10.1007/s00213-015-3993-z. Epub 2015 Jun 28. Psychopharmacology (Berl). 2015. PMID: 26123321 Free PMC article.
Inhibition of AMPA receptors (AMPARs) containing transmembrane AMPAR regulatory protein γ-8 with JNJ-55511118 shows preclinical efficacy in reducing chronic repetitive alcohol self-administration.
Hoffman JL, Faccidomo S, Saunders BL, Taylor SM, Kim M, Hodge CW. Hoffman JL, et al. Among authors: faccidomo s. Alcohol Clin Exp Res. 2021 Jul;45(7):1424-1435. doi: 10.1111/acer.14639. Epub 2021 Jun 22. Alcohol Clin Exp Res. 2021. PMID: 34086361 Free PMC article.
Negative modulation of AMPA receptors bound to transmembrane AMPA receptor regulatory protein γ-8 blunts the positive reinforcing properties of alcohol and sucrose in a brain region-dependent manner in male mice.
Hoffman JL, Faccidomo SP, Taylor SM, DeMiceli KG, May AM, Smith EN, Whindleton CM, Hodge CW. Hoffman JL, et al. Among authors: faccidomo sp. Psychopharmacology (Berl). 2023 Jun;240(6):1261-1273. doi: 10.1007/s00213-023-06365-z. Epub 2023 Apr 13. Psychopharmacology (Berl). 2023. PMID: 37055596 Free PMC article.
36 results