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Thiazole-based IL-17 inhibitors discovered by scaffold morphing.
Velcicky J, Ngo E, Bauer MR, Meyer A, Schlapbach A, Racine S, Orain D, Pflieger D, Teixeira-Fouchard S, Dubois C, Goetz A, Steiner R, Palmieri M, Bussenault A, Stringer R, Larger P, Riek S, Schmutz P, Lehmann S, Scheufler C, Rondeau JM, Burkhart C, Knoepfel T, Gommermann N. Velcicky J, et al. Among authors: bussenault a. ChemMedChem. 2024 Dec 23:e202400851. doi: 10.1002/cmdc.202400851. Online ahead of print. ChemMedChem. 2024. PMID: 39715021
FANCI functions as a repair/apoptosis switch in response to DNA crosslinks.
Shah RB, Kernan JL, van Hoogstraten A, Ando K, Li Y, Belcher AL, Mininger I, Bussenault AM, Raman R, Ramanagoudr-Bhojappa R, Huang TT, D'Andrea AD, Chandrasekharappa SC, Aggarwal AK, Thompson R, Sidi S. Shah RB, et al. Among authors: bussenault am. Dev Cell. 2021 Aug 9;56(15):2207-2222.e7. doi: 10.1016/j.devcel.2021.06.010. Epub 2021 Jul 12. Dev Cell. 2021. PMID: 34256011 Free PMC article.