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Page 1
Thoughts for the future.
Alkhalaf LM, Arrowsmith C, Balskus EP, Bergamini G, Bhandari R, Chang CJ, Chen P, Chen X, Ciulli A, Cricco JA, Davis BG, Delbianco M, Dudareva N, Dueber E, Ferguson F, de Giuseppe PO, Hamachi I, Hammond MC, Hatzios SK, Do Heo W, Janet JP, Kamat SS, Knapp S, Krishnan Y, Lang K, Laraia L, Leveson-Gower RB, Li XD, Liu DR, Liu MF, London N, Mahanta N, Mayor-Ruiz C, Muir T, Murakami MT, Rhee HW, Robers M, Satz A, Schulman BA, Shen B, Shoichet B, Strauss E, Suzuki T, Tiwary P, Waldmann H, Ward TR, Weeks A, Weerapana E, Winter G. Alkhalaf LM, et al. Among authors: knapp s. Nat Chem Biol. 2025 Jan;21(1):6-15. doi: 10.1038/s41589-024-01802-2. Nat Chem Biol. 2025. PMID: 39719500 No abstract available.
Probing the Protein Kinases' Cysteinome by Covalent Fragments.
Wang G, Seidler NJ, Röhm S, Pan Y, Liang XJ, Haarer L, Berger BT, Sivashanmugam SA, Wydra VR, Forster M, Laufer SA, Chaikuad A, Gehringer M, Knapp S. Wang G, et al. Among authors: knapp s. Angew Chem Int Ed Engl. 2024 Dec 24:e202419736. doi: 10.1002/anie.202419736. Online ahead of print. Angew Chem Int Ed Engl. 2024. PMID: 39716901
DARPins as a novel tool to detect and degrade p73.
Münick P, Zielinski J, Strubel A, Gutfreund N, Dreier B, Schaefer JV, Schäfer B, Gebel J, Osterburg C, Chaikuad A, Knapp S, Plückthun A, Dötsch V. Münick P, et al. Among authors: knapp s. Cell Death Dis. 2024 Dec 18;15(12):909. doi: 10.1038/s41419-024-07304-2. Cell Death Dis. 2024. PMID: 39695090 Free PMC article.
The C-terminal PHDVC5HCH tandem domain of NSD2 is a combinatorial reader of unmodified H3K4 and tri-methylated H3K27 that regulates transcription of cell adhesion genes in multiple myeloma.
Berardi A, Kaestner CL, Ghitti M, Quilici G, Cocomazzi P, Li J, Ballabio F, Zucchelli C, Knapp S, Licht JD, Musco G. Berardi A, et al. Among authors: knapp s. Nucleic Acids Res. 2024 Dec 5:gkae1121. doi: 10.1093/nar/gkae1121. Online ahead of print. Nucleic Acids Res. 2024. PMID: 39656918
Cannabis use and heart transplant listing: A survey of clinician practices.
J Ilonze O, Knapp SM, Chernyak Y, Page RL 2nd, Boyd LJ, Mazimba S, Raman SV, Enyi CO, Allen LA, Breathett K. J Ilonze O, et al. Among authors: knapp sm. PLoS One. 2024 Dec 12;19(12):e0310778. doi: 10.1371/journal.pone.0310778. eCollection 2024. PLoS One. 2024. PMID: 39666766 Free PMC article.
Toward target 2035: EUbOPEN - a public-private partnership to enable & unlock biology in the open.
Tredup C, Ackloo S, Beck H, Brown PJ, Bullock AN, Ciulli A, Dikic I, Edfeldt K, Edwards AM, Elkins JM, Farin HF, Fon EA, Gstaiger M, Günther J, Gustavsson AL, Häberle S, Isigkeit L, Huber KVM, Kotschy A, Krämer O, Leach AR, Marsden BD, Matsui H, Merk D, Montel F, Mulder MPC, Müller S, Owen DR, Proschak E, Röhm S, Stolz A, Sundström M, von Delft F, Willson TM, Arrowsmith CH, Knapp S. Tredup C, et al. Among authors: knapp s. RSC Med Chem. 2024 Nov 29. doi: 10.1039/d4md00735b. Online ahead of print. RSC Med Chem. 2024. PMID: 39618964 Free PMC article.
Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets.
Schwalm MP, Dopfer J, Kumar A, Greco FA, Bauer N, Löhr F, Heering J, Cano-Franco S, Lechner S, Hanke T, Jaser I, Morasch V, Lenz C, Fearon D, Marples PG, Tomlinson CWE, Brunello L, Saxena K, Adams NBP, von Delft F, Müller S, Stolz A, Proschak E, Kuster B, Knapp S, Rogov VV. Schwalm MP, et al. Among authors: knapp s. Nat Commun. 2024 Nov 25;15(1):10204. doi: 10.1038/s41467-024-54409-5. Nat Commun. 2024. PMID: 39587067 Free PMC article.
The endocannabinoid anandamide mediates anti-inflammatory effects through activation of NR4A nuclear receptors.
Teichmann T, Pflüger-Müller B, Giménez VMM, Sailer F, Dirks H, Zehr S, Warwick T, Brettner F, Munoz-Tello P, Zimmer A, Tegeder I, Thomas D, Gurke R, Günther S, Heering J, Proschak E, Geisslinger G, Bibli IS, Heringdorf DMZ, Manucha W, Windbergs M, Knapp S, Weigert A, Leisegang MS, Kojetin D, Brandes RP. Teichmann T, et al. Among authors: knapp s. Br J Pharmacol. 2024 Nov 19. doi: 10.1111/bph.17366. Online ahead of print. Br J Pharmacol. 2024. PMID: 39563075
Type-II kinase inhibitors that target Parkinson's Disease-associated LRRK2.
Raig ND, Surridge KJ, Sanz-Murillo M, Dederer V, Krämer A, Schwalm MP, Elson L, Chatterjee D, Mathea S, Hanke T, Leschziner AE, Reck-Peterson SL, Knapp S. Raig ND, et al. Among authors: knapp s. bioRxiv [Preprint]. 2024 Oct 31:2024.09.17.613365. doi: 10.1101/2024.09.17.613365. bioRxiv. 2024. PMID: 39554022 Free PMC article. Preprint.
1,325 results