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Page 1
Thoughts for the future.
Alkhalaf LM, Arrowsmith C, Balskus EP, Bergamini G, Bhandari R, Chang CJ, Chen P, Chen X, Ciulli A, Cricco JA, Davis BG, Delbianco M, Dudareva N, Dueber E, Ferguson F, de Giuseppe PO, Hamachi I, Hammond MC, Hatzios SK, Do Heo W, Janet JP, Kamat SS, Knapp S, Krishnan Y, Lang K, Laraia L, Leveson-Gower RB, Li XD, Liu DR, Liu MF, London N, Mahanta N, Mayor-Ruiz C, Muir T, Murakami MT, Rhee HW, Robers M, Satz A, Schulman BA, Shen B, Shoichet B, Strauss E, Suzuki T, Tiwary P, Waldmann H, Ward TR, Weeks A, Weerapana E, Winter G. Alkhalaf LM, et al. Among authors: schulman ba. Nat Chem Biol. 2025 Jan;21(1):6-15. doi: 10.1038/s41589-024-01802-2. Nat Chem Biol. 2025. PMID: 39719500 No abstract available.
Structural basis for C-degron selectivity across KLHDCX family E3 ubiquitin ligases.
Scott DC, Chittori S, Purser N, King MT, Maiwald SA, Churion K, Nourse A, Lee C, Paulo JA, Miller DJ, Elledge SJ, Harper JW, Kleiger G, Schulman BA. Scott DC, et al. Among authors: schulman ba. Nat Commun. 2024 Nov 15;15(1):9899. doi: 10.1038/s41467-024-54126-z. Nat Commun. 2024. PMID: 39548056 Free PMC article.
Ubiquitin is a chemist's playground.
Farnung J, Schulman BA. Farnung J, et al. Among authors: schulman ba. Nat Chem. 2024 Nov;16(11):1918. doi: 10.1038/s41557-024-01660-4. Nat Chem. 2024. PMID: 39482375 No abstract available.
Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2.
Scott DC, Dharuman S, Griffith E, Chai SC, Ronnebaum J, King MT, Tangallapally R, Lee C, Gee CT, Yang L, Li Y, Loudon VC, Lee HW, Ochoada J, Miller DJ, Jayasinghe T, Paulo JA, Elledge SJ, Harper JW, Chen T, Lee RE, Schulman BA. Scott DC, et al. Among authors: schulman ba. Nat Commun. 2024 Oct 12;15(1):8829. doi: 10.1038/s41467-024-52966-3. Nat Commun. 2024. PMID: 39396041 Free PMC article.
Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3.
Hennes E, Lucas B, Scholes NS, Cheng XF, Scott DC, Bischoff M, Reich K, Gasper R, Lucas M, Xu TT, Pulvermacher LM, Dötsch L, Imrichova H, Brause A, Naredla KR, Sievers S, Kumar K, Janning P, Gersch M, Murray PJ, Schulman BA, Winter GE, Ziegler S, Waldmann H. Hennes E, et al. Among authors: schulman ba. bioRxiv [Preprint]. 2024 Jul 13:2024.07.10.602857. doi: 10.1101/2024.07.10.602857. bioRxiv. 2024. PMID: 39026748 Free PMC article. Preprint.
Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation.
Kagiou C, Cisneros JA, Farnung J, Liwocha J, Offensperger F, Dong K, Yang K, Tin G, Horstmann CS, Hinterndorfer M, Paulo JA, Scholes NS, Sanchez Avila J, Fellner M, Andersch F, Hannich JT, Zuber J, Kubicek S, Gygi SP, Schulman BA, Winter GE. Kagiou C, et al. Among authors: schulman ba. Nat Commun. 2024 Jun 26;15(1):5409. doi: 10.1038/s41467-024-49739-3. Nat Commun. 2024. PMID: 38926334 Free PMC article.
Noncanonical assembly, neddylation and chimeric cullin-RING/RBR ubiquitylation by the 1.8 MDa CUL9 E3 ligase complex.
Horn-Ghetko D, Hopf LVM, Tripathi-Giesgen I, Du J, Kostrhon S, Vu DT, Beier V, Steigenberger B, Prabu JR, Stier L, Bruss EM, Mann M, Xiong Y, Schulman BA. Horn-Ghetko D, et al. Among authors: schulman ba. Nat Struct Mol Biol. 2024 Jul;31(7):1083-1094. doi: 10.1038/s41594-024-01257-y. Epub 2024 Apr 11. Nat Struct Mol Biol. 2024. PMID: 38605244 Free PMC article.
Visualizing chaperone-mediated multistep assembly of the human 20S proteasome.
Adolf F, Du J, Goodall EA, Walsh RM Jr, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA. Adolf F, et al. Among authors: schulman ba. Nat Struct Mol Biol. 2024 Aug;31(8):1176-1188. doi: 10.1038/s41594-024-01268-9. Epub 2024 Apr 10. Nat Struct Mol Biol. 2024. PMID: 38600324 Free PMC article.
202 results