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Bats generate lower affinity but higher diversity antibody responses than those of mice, but pathogen-binding capacity increases if protein is restricted in their diet.
Crowley DE, Falvo CA, Benson E, Hedges J, Jutila M, Ezzatpour S, Aguilar HC, Ruiz-Aravena M, Ma W, Schountz T, Rynda-Apple A, Plowright RK. Crowley DE, et al. Among authors: aguilar hc. PLoS Biol. 2024 Sep 24;22(9):e3002800. doi: 10.1371/journal.pbio.3002800. eCollection 2024 Sep. PLoS Biol. 2024. PMID: 39316608 Free PMC article.
Novel requirements for HAP2/GCS1-mediated gamete fusion in Tetrahymena.
Pinello JF, Loidl J, Seltzer ES, Cassidy-Hanley D, Kolbin D, Abdelatif A, Rey FA, An R, Newberger NJ, Bisharyan Y, Papoyan H, Byun H, Aguilar HC, Lai AL, Freed JH, Maugel T, Cole ES, Clark TG. Pinello JF, et al. Among authors: aguilar hc. iScience. 2024 May 28;27(6):110146. doi: 10.1016/j.isci.2024.110146. eCollection 2024 Jun 21. iScience. 2024. PMID: 38904066 Free PMC article.
Functional assessment of the glycoproteins of a novel Hendra virus variant reveals contrasting fusogenic capacities of the receptor-binding and fusion glycoproteins.
Ma AZ, Yeo YY, Lee JF, Kim CM, Ezzatpour S, Menchaca C, Upadhye V, Annand EJ, Eden J-S, Plowright RK, Peel AJ, Buchholz DW, Aguilar HC. Ma AZ, et al. Among authors: aguilar hc. mBio. 2024 Dec 20:e0348223. doi: 10.1128/mbio.03482-23. Online ahead of print. mBio. 2024. PMID: 39704501 Free article.
Glutamine metabolism is essential for coronavirus replication in host cells and in mice.
Greene KS, Choi A, Yang N, Chen M, Li R, Qiu Y, Ezzatpour S, Rojas KS, Shen J, Wilson KF, Katt WP, Aguilar HC, Lukey MJ, Whittaker GR, Cerione RA. Greene KS, et al. Among authors: aguilar hc. J Biol Chem. 2024 Dec 9;301(1):108063. doi: 10.1016/j.jbc.2024.108063. Online ahead of print. J Biol Chem. 2024. PMID: 39662828 Free article.
Antibody inhibition of measles virus entry.
Aguilar HC. Aguilar HC. Science. 2024 Jun 28;384(6703):1406-1407. doi: 10.1126/science.adq3348. Epub 2024 Jun 27. Science. 2024. PMID: 38935737
Adaptive immune cells are necessary for SARS-CoV-2-induced pathology.
Imbiakha B, Sahler JM, Buchholz DW, Ezzatpour S, Jager M, Choi A, Monreal IA, Byun H, Adeleke RA, Leach J, Whittaker G, Dewhurst S, Rudd BD, Aguilar HC, August A. Imbiakha B, et al. Among authors: aguilar hc. Sci Adv. 2024 Jan 5;10(1):eadg5461. doi: 10.1126/sciadv.adg5461. Epub 2024 Jan 3. Sci Adv. 2024. PMID: 38170764 Free PMC article.
Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2 infected older mice with neurological signs.
Rahman SM, Buchholz DW, Imbiakha B, Jaeger MC, Leach J, Osborn RM, Birmingham AO, Dewhurst S, Aguilar HC, Luebke AE. Rahman SM, et al. Among authors: aguilar hc. bioRxiv [Preprint]. 2024 Jan 23:2023.10.23.563669. doi: 10.1101/2023.10.23.563669. bioRxiv. 2024. Update in: J Virol. 2024 Jul 23;98(7):e0006624. doi: 10.1128/jvi.00066-24 PMID: 37965203 Free PMC article. Updated. Preprint.
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