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Transforming growth factor beta receptor type I (TGF-βRI) kinase inhibitors IOA-359 and IOA-360 stimulate erythropoiesis in MDS.
Ramachandra N, Vegivinti CTR, Sahu S, Sanawar R, Rivera-Peña B, Aminov S, Fromowitz A, Zhang J, Aodengtuya F, Pradhan K, Zhao R, Schwartz L, Alluri S, Thiruvananthapuram V, Rabinovich E, Ajibade O, Gordon-Mitchell S, Shastri A, Deken M, Yingling JM, Sawyer S, Lahn M, Verma A. Ramachandra N, et al. Among authors: sahu s. Leuk Lymphoma. 2024 Dec 27:1-10. doi: 10.1080/10428194.2024.2444479. Online ahead of print. Leuk Lymphoma. 2024. PMID: 39727008
Role of innate immunological/inflammatory pathways in myelodysplastic syndromes and AML: a narrative review.
Vegivinti CTR, Keesari PR, Veeraballi S, Martins Maia CMP, Mehta AK, Lavu RR, Thakur RK, Tella SH, Patel R, Kakumani VK, Pulakurthi YS, Aluri S, Aggarwal RK, Ramachandra N, Zhao R, Sahu S, Shastri A, Verma A. Vegivinti CTR, et al. Among authors: sahu s. Exp Hematol Oncol. 2023 Jul 8;12(1):60. doi: 10.1186/s40164-023-00422-1. Exp Hematol Oncol. 2023. PMID: 37422676 Free PMC article. Review.
Activation of targetable inflammatory immune signaling is seen in myelodysplastic syndromes with SF3B1 mutations.
Choudhary GS, Pellagatti A, Agianian B, Smith MA, Bhagat TD, Gordon-Mitchell S, Sahu S, Pandey S, Shah N, Aluri S, Aggarwal R, Aminov S, Schwartz L, Steeples V, Booher RN, Ramachandra M, Samson M, Carbajal M, Pradhan K, Bowman TV, Pillai MM, Will B, Wickrema A, Shastri A, Bradley RK, Martell RE, Steidl UG, Gavathiotis E, Boultwood J, Starczynowski DT, Verma A. Choudhary GS, et al. Among authors: sahu s. Elife. 2022 Aug 30;11:e78136. doi: 10.7554/eLife.78136. Elife. 2022. PMID: 36040792 Free PMC article.
ASXL1 mutations are associated with distinct epigenomic alterations that lead to sensitivity to venetoclax and azacytidine.
Rahmani NE, Ramachandra N, Sahu S, Gitego N, Lopez A, Pradhan K, Bhagat TD, Gordon-Mitchell S, Pena BR, Kazemi M, Rao K, Giricz O, Maqbool SB, Olea R, Zhao Y, Zhang J, Dolatshad H, Tittrea V, Tatwavedi D, Singh S, Lee J, Sun T, Steidl U, Shastri A, Inoue D, Abdel-Wahab O, Pellagatti A, Gavathiotis E, Boultwood J, Verma A. Rahmani NE, et al. Among authors: sahu s. Blood Cancer J. 2021 Sep 21;11(9):157. doi: 10.1038/s41408-021-00541-0. Blood Cancer J. 2021. PMID: 34548471 Free PMC article.
Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency.
Aminov S, Giricz O, Melnekoff DT, Sica RA, Polishchuk V, Papazoglu C, Yates B, Wang HW, Sahu S, Wang Y, Gordon-Mitchell S, Leshchenko VV, Schinke C, Pradhan K, Aluri S, Sohn M, Barta SK, Agarwal B, Goldfinger M, Mantzaris I, Shastri A, Matsui W, Steidl U, Brody JD, Shah NN, Parekh S, Verma A. Aminov S, et al. Among authors: sahu s. J Clin Invest. 2024 Feb 20;134(8):e175199. doi: 10.1172/JCI175199. J Clin Invest. 2024. PMID: 38376944 Free PMC article.
Smoking carcinogen induced inflammation promotes lung carcinogenesis via IRAK4 activation.
Aggarwal RK, Sidoli S, Wang J, Sahu S, Sanawar R, Gupta V, Aluri S, Sukrithan V, Vegivinti CTR, Zavras PD, Verma D, Gordon-Mitchell S, Agarwal B, Verma T, Starczynowski DT, Steidl UG, Shastri A, Halmos B, LaFave LM, Cheng H, Verma A, Zou Y. Aggarwal RK, et al. Among authors: sahu s. Clin Cancer Res. 2024 Dec 20. doi: 10.1158/1078-0432.CCR-24-2182. Online ahead of print. Clin Cancer Res. 2024. PMID: 39704655
Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer.
Zhang Y, Chen X, Wang H, Gordon-Mitchell S, Sahu S, Bhagat TD, Choudhary G, Aluri S, Pradhan K, Sahu P, Carbajal M, Zhang H, Agarwal B, Shastri A, Martell R, Starczynowski D, Steidl U, Maitra A, Verma A. Zhang Y, et al. Among authors: sahu s, sahu p. J Hematol Oncol. 2022 May 23;15(1):70. doi: 10.1186/s13045-022-01286-4. J Hematol Oncol. 2022. PMID: 35606824 Free PMC article.
Correction: Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer.
Zhang Y, Chen X, Wang H, Gordon-Mitchell S, Sahu S, Bhagat TD, Choudhary G, Aluri S, Pradhan K, Sahu P, Carbajal M, Zhang H, Agarwal B, Shastri A, Martell R, Starczynowski D, Steidl U, Maitra A, Verma A. Zhang Y, et al. Among authors: sahu s, sahu p. J Hematol Oncol. 2022 Jul 26;15(1):100. doi: 10.1186/s13045-022-01321-4. J Hematol Oncol. 2022. PMID: 35883108 Free PMC article. No abstract available.
Glutaminase inhibition in combination with azacytidine in myelodysplastic syndromes: a phase 1b/2 clinical trial and correlative analyses.
DiNardo CD, Verma D, Baran N, Bhagat TD, Skwarska A, Lodi A, Saxena K, Cai T, Su X, Guerra VA, Poigaialwar G, Kuruvilla VM, Konoplev S, Gordon-Mitchell S, Pradhan K, Aluri S, Hackman GL, Chaudhry S, Collins M, Sweeney SR, Busquets J, Rathore AS, Deng Q, Green MR, Grant S, Demo S, Choudhary GS, Sahu S, Agarwal B, Spodek M, Thiruthuvanathan V, Will B, Steidl U, Tippett GD, Burger J, Borthakur G, Jabbour E, Pemmaraju N, Kadia T, Kornblau S, Daver NG, Naqvi K, Short NJ, Garcia-Manero G, Tiziani S, Verma A, Konopleva M. DiNardo CD, et al. Among authors: sahu s. Nat Cancer. 2024 Oct;5(10):1515-1533. doi: 10.1038/s43018-024-00811-3. Epub 2024 Sep 19. Nat Cancer. 2024. PMID: 39300320 Clinical Trial.
High burden of clonal hematopoiesis in first responders exposed to the World Trade Center disaster.
Jasra S, Giricz O, Zeig-Owens R, Pradhan K, Goldfarb DG, Barreto-Galvez A, Silver AJ, Chen J, Sahu S, Gordon-Mitchell S, Choudhary GS, Aluri S, Bhagat TD, Shastri A, Bejan CA, Stockton SS, Spaulding TP, Thiruthuvanathan V, Goto H, Gerhardt J, Haider SH, Veerappan A, Bartenstein M, Nwankwo G, Landgren O, Weiden MD, Lekostaj J, Bender R, Fletcher F, Greenberger L, Ebert BL, Steidl U, Will B, Nolan A, Madireddy A, Savona MR, Prezant DJ, Verma A. Jasra S, et al. Among authors: sahu s. Nat Med. 2022 Mar;28(3):468-471. doi: 10.1038/s41591-022-01708-3. Epub 2022 Mar 7. Nat Med. 2022. PMID: 35256801 Free PMC article.
2,072 results