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G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability.
Trussina IREA, Hartmann A, Desroches Altamirano C, Natarajan J, Fischer CM, Aleksejczuk M, Ausserwöger H, Knowles TPJ, Schlierf M, Franzmann TM, Alberti S. Trussina IREA, et al. Among authors: ausserwoger h. Mol Cell. 2024 Dec 19:S1097-2765(24)00994-8. doi: 10.1016/j.molcel.2024.11.039. Online ahead of print. Mol Cell. 2024. PMID: 39729994 Free article.
Solutes unmask differences in clustering versus phase separation of FET proteins.
Kar M, Vogel LT, Chauhan G, Felekyan S, Ausserwöger H, Welsh TJ, Dar F, Kamath AR, Knowles TPJ, Hyman AA, Seidel CAM, Pappu RV. Kar M, et al. Among authors: ausserwoger h. Nat Commun. 2024 May 23;15(1):4408. doi: 10.1038/s41467-024-48775-3. Nat Commun. 2024. PMID: 38782886 Free PMC article.
Nonspecificity fingerprints for clinical-stage antibodies in solution.
Herling TW, Invernizzi G, Ausserwöger H, Bjelke JR, Egebjerg T, Lund S, Lorenzen N, Knowles TPJ. Herling TW, et al. Among authors: ausserwoger h. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2306700120. doi: 10.1073/pnas.2306700120. Epub 2023 Dec 18. Proc Natl Acad Sci U S A. 2023. PMID: 38109540 Free PMC article.
Glutamate helps unmask the differences in driving forces for phase separation versus clustering of FET family proteins in sub-saturated solutions.
Kar M, Vogel LT, Chauhan G, Ausserwöger H, Welsh TJ, Kamath AR, Knowles TPJ, Hyman AA, Seidel CAM, Pappu RV. Kar M, et al. Among authors: ausserwoger h. Res Sq [Preprint]. 2023 Sep 18:rs.3.rs-3252197. doi: 10.21203/rs.3.rs-3252197/v1. Res Sq. 2023. Update in: Nat Commun. 2024 May 23;15(1):4408. doi: 10.1038/s41467-024-48775-3 PMID: 37790538 Free PMC article. Updated. Preprint.
Surface patches induce nonspecific binding and phase separation of antibodies.
Ausserwöger H, Krainer G, Welsh TJ, Thorsteinson N, de Csilléry E, Sneideris T, Schneider MM, Egebjerg T, Invernizzi G, Herling TW, Lorenzen N, Knowles TPJ. Ausserwöger H, et al. Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2210332120. doi: 10.1073/pnas.2210332120. Epub 2023 Apr 3. Proc Natl Acad Sci U S A. 2023. PMID: 37011217 Free PMC article.
13 results