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G3BP-driven RNP granules promote inhibitory RNA-RNA interactions resolved by DDX3X to regulate mRNA translatability.
Trussina IREA, Hartmann A, Desroches Altamirano C, Natarajan J, Fischer CM, Aleksejczuk M, Ausserwöger H, Knowles TPJ, Schlierf M, Franzmann TM, Alberti S. Trussina IREA, et al. Among authors: franzmann tm. Mol Cell. 2024 Dec 19:S1097-2765(24)00994-8. doi: 10.1016/j.molcel.2024.11.039. Online ahead of print. Mol Cell. 2024. PMID: 39729994 Free article.
RNA-Induced Conformational Switching and Clustering of G3BP Drive Stress Granule Assembly by Condensation.
Guillén-Boixet J, Kopach A, Holehouse AS, Wittmann S, Jahnel M, Schlüßler R, Kim K, Trussina IREA, Wang J, Mateju D, Poser I, Maharana S, Ruer-Gruß M, Richter D, Zhang X, Chang YT, Guck J, Honigmann A, Mahamid J, Hyman AA, Pappu RV, Alberti S, Franzmann TM. Guillén-Boixet J, et al. Among authors: franzmann tm. Cell. 2020 Apr 16;181(2):346-361.e17. doi: 10.1016/j.cell.2020.03.049. Cell. 2020. PMID: 32302572 Free PMC article.
eIF4F is a thermo-sensing regulatory node in the translational heat shock response.
Desroches Altamirano C, Kang MK, Jordan MA, Borianne T, Dilmen I, Gnädig M, von Appen A, Honigmann A, Franzmann TM, Alberti S. Desroches Altamirano C, et al. Among authors: franzmann tm. Mol Cell. 2024 May 2;84(9):1727-1741.e12. doi: 10.1016/j.molcel.2024.02.038. Epub 2024 Mar 27. Mol Cell. 2024. PMID: 38547866 Free article.
Protein Phase Separation as a Stress Survival Strategy.
Franzmann TM, Alberti S. Franzmann TM, et al. Cold Spring Harb Perspect Biol. 2019 Jun 3;11(6):a034058. doi: 10.1101/cshperspect.a034058. Cold Spring Harb Perspect Biol. 2019. PMID: 30617047 Free PMC article. Review.
Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production.
Iserman C, Desroches Altamirano C, Jegers C, Friedrich U, Zarin T, Fritsch AW, Mittasch M, Domingues A, Hersemann L, Jahnel M, Richter D, Guenther UP, Hentze MW, Moses AM, Hyman AA, Kramer G, Kreysing M, Franzmann TM, Alberti S. Iserman C, et al. Among authors: franzmann tm. Cell. 2020 May 14;181(4):818-831.e19. doi: 10.1016/j.cell.2020.04.009. Epub 2020 Apr 30. Cell. 2020. PMID: 32359423 Free PMC article.
A User's Guide for Phase Separation Assays with Purified Proteins.
Alberti S, Saha S, Woodruff JB, Franzmann TM, Wang J, Hyman AA. Alberti S, et al. Among authors: franzmann tm. J Mol Biol. 2018 Nov 2;430(23):4806-4820. doi: 10.1016/j.jmb.2018.06.038. Epub 2018 Jun 23. J Mol Biol. 2018. PMID: 29944854 Free PMC article.
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions.
Krainer G, Welsh TJ, Joseph JA, Espinosa JR, Wittmann S, de Csilléry E, Sridhar A, Toprakcioglu Z, Gudiškytė G, Czekalska MA, Arter WE, Guillén-Boixet J, Franzmann TM, Qamar S, George-Hyslop PS, Hyman AA, Collepardo-Guevara R, Alberti S, Knowles TPJ. Krainer G, et al. Among authors: franzmann tm. Nat Commun. 2021 Feb 17;12(1):1085. doi: 10.1038/s41467-021-21181-9. Nat Commun. 2021. PMID: 33597515 Free PMC article.
Phase-separating RNA-binding proteins form heterogeneous distributions of clusters in subsaturated solutions.
Kar M, Dar F, Welsh TJ, Vogel LT, Kühnemuth R, Majumdar A, Krainer G, Franzmann TM, Alberti S, Seidel CAM, Knowles TPJ, Hyman AA, Pappu RV. Kar M, et al. Among authors: franzmann tm. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2202222119. doi: 10.1073/pnas.2202222119. Epub 2022 Jul 5. Proc Natl Acad Sci U S A. 2022. PMID: 35787038 Free PMC article.
46 results