Deng L - Search Results

1

A Novel Bispecific Anti-IL17/VEGF Fusion Trap Exhibits Potent and Long-Lasting Inhibitory Effects on the Development of Age-Related Macular Degeneration.

Deng L, Wang L, Meng Y, Zheng J, Dong X, Chen Y, Huang H. Deng L, et al. Biochem Res Int. 2024 Dec 21;2024:1405338. doi: 10.1155/bri/1405338. eCollection 2024. Biochem Res Int. 2024. PMID: 39735855 Free PMC article.

2

The mechanism of action and biodistribution of a novel EGFR/VEGF bispecific fusion protein that exhibited superior antitumor activities.

Deng L, Wang L, Zhang J, Zhao L, Meng Y, Zheng J, Xu W, Zhu Z, Huang H. Deng L, et al. Heliyon. 2023 Jun 3;9(6):e16922. doi: 10.1016/j.heliyon.2023.e16922. eCollection 2023 Jun. Heliyon. 2023. PMID: 37484224 Free PMC article.

3

Tumor-targeting anti-EGFR x anti-PD1 bispecific antibody inhibits EGFR-overexpressing tumor growth by combining EGFR blockade and immune activation with direct tumor cell killing.

Li L, Deng L, Meng X, Gu C, Meng L, Li K, Zhang X, Meng Y, Xu W, Zhao L, Chen J, Zhu Z, Huang H. Li L, et al. Among authors: deng l. Transl Oncol. 2021 Jan;14(1):100916. doi: 10.1016/j.tranon.2020.100916. Epub 2020 Oct 22. Transl Oncol. 2021. PMID: 33129108 Free PMC article.

4

Construction of a novel TROP2/CD3 bispecific antibody with potent antitumor activity and reduced induction of Th1 cytokines.

Wang D, Zhang L, Wang B, Zhao L, Deng L, Xu W, Huang H. Wang D, et al. Among authors: deng l. Protein Expr Purif. 2023 May;205:106242. doi: 10.1016/j.pep.2023.106242. Epub 2023 Feb 5. Protein Expr Purif. 2023. PMID: 36746324 Free article.

5

Systemic investigation of inetetamab in combination with small molecules to treat HER2-overexpressing breast and gastric cancers.

Deng L, Zhao L, Liu L, Huang H. Deng L, et al. Open Life Sci. 2023 Jan 10;18(1):20220535. doi: 10.1515/biol-2022-0535. eCollection 2023. Open Life Sci. 2023. PMID: 36694697 Free PMC article.

6

A strategy for the efficient construction of anti-PD1-based bispecific antibodies with desired IgG-like properties.

Zhao J, Jiang L, Yang H, Deng L, Meng X, Ding J, Yang S, Zhao L, Xu W, Wang X, Zhu Z, Huang H. Zhao J, et al. Among authors: deng l. MAbs. 2022 Jan-Dec;14(1):2044435. doi: 10.1080/19420862.2022.2044435. MAbs. 2022. PMID: 35239451 Free PMC article.

7

Important roles of CD32 in promoting suppression of IL-4 induced immune responses by a novel anti-IL-4Rα therapeutic antibody.

Zhao J, Jiang L, Deng L, Xu W, Cao Y, Chen C, Yang Y, Wu H, Huang Y, Zhu Z, Huang H. Zhao J, et al. Among authors: deng l. MAbs. 2019 Jul;11(5):837-847. doi: 10.1080/19420862.2019.1601985. Epub 2019 Apr 29. MAbs. 2019. PMID: 30950681 Free PMC article.

8

Bispecific antibody simultaneously targeting PD1 and HER2 inhibits tumor growth via direct tumor cell killing in combination with PD1/PDL1 blockade and HER2 inhibition.

Gu CL, Zhu HX, Deng L, Meng XQ, Li K, Xu W, Zhao L, Liu YQ, Zhu ZP, Huang HM. Gu CL, et al. Among authors: deng l. Acta Pharmacol Sin. 2022 Mar;43(3):672-680. doi: 10.1038/s41401-021-00683-8. Epub 2021 May 14. Acta Pharmacol Sin. 2022. PMID: 33990766 Free PMC article.

9

A new anti-HER2 antibody that enhances the anti-tumor efficacy of trastuzumab and pertuzumab with a distinct mechanism of action.

Zhang X, Chen J, Weng Z, Li Q, Zhao L, Yu N, Deng L, Xu W, Yang Y, Zhu Z, Huang H. Zhang X, et al. Among authors: deng l. Mol Immunol. 2020 Mar;119:48-58. doi: 10.1016/j.molimm.2020.01.009. Epub 2020 Jan 21. Mol Immunol. 2020. PMID: 31978707 Free article.

10

Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1, and JN.1.

Tong Z, Tong J, Lei W, Xie Y, Cui Y, Jia G, Li S, Zhang Z, Cheng Z, Xing X, Ma H, Deng L, Zhang R, Zhao X, Liu K, Wang Q, Qi J, Huang H, Song R, Su Z, Wu G, Lou J, Gao GF. Tong Z, et al. Among authors: deng l. Cell Rep. 2024 Jun 25;43(6):114338. doi: 10.1016/j.celrep.2024.114338. Epub 2024 Jun 8. Cell Rep. 2024. PMID: 38850530 Free article.

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