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82 results

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Localized molecular chaperone synthesis maintains neuronal dendrite proteostasis.
Alecki C, Rizwan J, Le P, Jacob-Tomas S, Comaduran MF, Verbrugghe M, Xu JMS, Minotti S, Lynch J, Biswas J, Wu T, Durham HD, Yeo GW, Vera M. Alecki C, et al. Among authors: durham hd. Nat Commun. 2024 Dec 30;15(1):10796. doi: 10.1038/s41467-024-55055-7. Nat Commun. 2024. PMID: 39737952 Free PMC article.
Reversal of cognitive deficits in FUSR521G amyotrophic lateral sclerosis mice by arimoclomol and a class I histone deacetylase inhibitor independent of heat shock protein induction.
Pelaez MC, Fiore F, Larochelle N, Dabbaghizadeh A, Comaduran MF, Arbour D, Minotti S, Marcadet L, Semaan M, Robitaille R, Nalbantoglu JN, Sephton CF, Durham HD. Pelaez MC, et al. Among authors: durham hd. Neurotherapeutics. 2024 Sep;21(5):e00388. doi: 10.1016/j.neurot.2024.e00388. Epub 2024 Jul 6. Neurotherapeutics. 2024. PMID: 38972779 Free PMC article.
Impact of histone deacetylase inhibition and arimoclomol on heat shock protein expression and disease biomarkers in primary culture models of familial ALS.
Fernández Comaduran M, Minotti S, Jacob-Tomas S, Rizwan J, Larochelle N, Robitaille R, Sephton CF, Vera M, Nalbantoglu JN, Durham HD. Fernández Comaduran M, et al. Among authors: durham hd. Cell Stress Chaperones. 2024 Jun;29(3):359-380. doi: 10.1016/j.cstres.2024.03.010. Epub 2024 Apr 1. Cell Stress Chaperones. 2024. PMID: 38570009 Free PMC article.
The J Domain of Sacsin Disrupts Intermediate Filament Assembly.
Dabbaghizadeh A, Paré A, Cheng-Boivin Z, Dagher R, Minotti S, Dicaire MJ, Brais B, Young JC, Durham HD, Gentil BJ. Dabbaghizadeh A, et al. Among authors: durham hd. Int J Mol Sci. 2022 Dec 12;23(24):15742. doi: 10.3390/ijms232415742. Int J Mol Sci. 2022. PMID: 36555380 Free PMC article.
Editorial: The Role of Heat Shock Proteins in Neuroprotection.
Santha M, Durham HD, Vigh L, Prodromou C. Santha M, et al. Among authors: durham hd. Front Pharmacol. 2020 Aug 6;11:1227. doi: 10.3389/fphar.2020.01227. eCollection 2020. Front Pharmacol. 2020. PMID: 32848805 Free PMC article. No abstract available.
Neurofilaments: neurobiological foundations for biomarker applications.
Gafson AR, Barthélemy NR, Bomont P, Carare RO, Durham HD, Julien JP, Kuhle J, Leppert D, Nixon RA, Weller RO, Zetterberg H, Matthews PM. Gafson AR, et al. Among authors: durham hd. Brain. 2020 Jul 1;143(7):1975-1998. doi: 10.1093/brain/awaa098. Brain. 2020. PMID: 32408345 Free PMC article. Review.
Depending on the stress, histone deacetylase inhibitors act as heat shock protein co-inducers in motor neurons and potentiate arimoclomol, exerting neuroprotection through multiple mechanisms in ALS models.
Kuta R, Larochelle N, Fernandez M, Pal A, Minotti S, Tibshirani M, St Louis K, Gentil BJ, Nalbantoglu JN, Hermann A, Durham HD. Kuta R, et al. Among authors: durham hd. Cell Stress Chaperones. 2020 Jan;25(1):173-191. doi: 10.1007/s12192-019-01064-1. Epub 2020 Jan 3. Cell Stress Chaperones. 2020. PMID: 31900865 Free PMC article.
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