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Page 1
The striatum is an early, accurate indicator of amyloid burden using [11C]PiB in Down syndrome: comparison of two radiotracers.
McLachlan M, Bettcher B, McVea A, DiFillipo A, Zammit M, LeMerise L, Rouanet J, Price J, Tudorascu D, Laymon C, Keator D, Lao P, Brickman AM, Fryer T, Hartley S, Ances BM, Johnson S, Betthauser T, Stone CK, Zaman S, Handen B, Head E, Mapstone M, Christian BT. McLachlan M, et al. Among authors: christian bt. medRxiv [Preprint]. 2024 Dec 6:2024.12.04.24318526. doi: 10.1101/2024.12.04.24318526. medRxiv. 2024. PMID: 39677434 Free PMC article. Preprint.
Timeline to symptomatic Alzheimer's disease in people with Down syndrome as assessed by amyloid-PET and tau-PET: a longitudinal cohort study.
Schworer EK, Zammit MD, Wang J, Handen BL, Betthauser T, Laymon CM, Tudorascu DL, Cohen AD, Zaman SH, Ances BM, Mapstone M, Head E, Christian BT, Hartley SL; Alzheimer's Biomarker Consortium–Down Syndrome (ABC–DS). Schworer EK, et al. Among authors: christian bt. Lancet Neurol. 2024 Dec;23(12):1214-1224. doi: 10.1016/S1474-4422(24)00426-5. Lancet Neurol. 2024. PMID: 39577922
Visual read of [F-18]florquinitau PET that includes and extends beyond the mesial temporal lobe is associated with increased plasma pTau217 and cognitive decline in a cohort that is enriched with risk for Alzheimer's disease.
Rea Reyes RE, Cody KA, Wilson RE, Zetterberg H, Chin NA, Jonaitis EM, Bahr M, Mandel O, Wintlend M, Bendlin BB, Okonkwo OC, Clark LR, Zammit M, Asthana S, Christian BT, Betthauser TJ, Eisenmenger L, Langhough RE, Johnson SC. Rea Reyes RE, et al. Among authors: christian bt. Alzheimers Dement. 2024 Nov 19. doi: 10.1002/alz.14406. Online ahead of print. Alzheimers Dement. 2024. PMID: 39560002
The effects of mosaicism on biological and clinical markers of Alzheimer's disease in adults with Down syndrome.
Xicota L, Dang LT, Lee A, Krinsky-McHale S, Pang D, Melilli L, O'Bryant S, Henson RL, Laymon C, Lai F, Rosas HD, Ances B, Lott I, Hom C, Christian B, Hartley S, Zaman S, Head E, Mapstone M, Jin Z, Silverman W, Schupf N, Handen B, Lee JH; Alzheimer's Biomarker Consortium – Down Syndrome (ABC-DS). Xicota L, et al. EBioMedicine. 2024 Dec;110:105433. doi: 10.1016/j.ebiom.2024.105433. Epub 2024 Nov 4. EBioMedicine. 2024. PMID: 39500037 Free PMC article.
Cerebrovascular disease is associated with Alzheimer's plasma biomarker concentrations in adults with Down syndrome.
Edwards NC, Lao PJ, Alshikho MJ, Ericsson OM, Rizvi B, Petersen ME, O'Bryant S, Aguilar LF, Simoes S, Mapstone M, Tudorascu DL, Janelidze S, Hansson O, Handen BL, Christian BT, Lee JH, Lai F, Rosas HD, Zaman S, Lott IT, Yassa MA; Alzheimer’s Biomarkers Consortium–Down Syndrome (ABC-DS) Investigators; Gutierrez J, Wilcock DM, Head E, Brickman AM. Edwards NC, et al. Among authors: christian bt. Brain Commun. 2024 Sep 25;6(5):fcae331. doi: 10.1093/braincomms/fcae331. eCollection 2024. Brain Commun. 2024. PMID: 39403075 Free PMC article.
Amyloid age and tau PET timeline to symptomatic Alzheimer's disease in Down syndrome.
Schworer EK, Zammit MD, Wang J, Handen BL, Betthauser T, Laymon CM, Tudorascu DL, Cohen AD, Zaman SH, Ances BM, Mapstone M, Head E, Klunk WE, Christian BT, Hartley SL; Alzheimer Biomarker Consortium – Down Syndrome (ABC-DS). Schworer EK, et al. Among authors: christian bt. medRxiv [Preprint]. 2024 Aug 9:2024.08.08.24311702. doi: 10.1101/2024.08.08.24311702. medRxiv. 2024. PMID: 39211859 Free PMC article. Preprint.
Cerebrovascular disease emerges with age and Alzheimer's disease in adults with Down syndrome.
Lao P, Edwards N, Flores-Aguilar L, Alshikho M, Rizvi B, Tudorascu D, Rosas HD, Yassa M, Christian BT, Mapstone M, Handen B, Zimmerman ME, Gutierrez J, Wilcock D, Head E, Brickman AM. Lao P, et al. Among authors: christian bt. Sci Rep. 2024 May 29;14(1):12334. doi: 10.1038/s41598-024-61962-y. Sci Rep. 2024. PMID: 38811657 Free PMC article.
Comparison of tau spread in people with Down syndrome versus autosomal-dominant Alzheimer's disease: a cross-sectional study.
Wisch JK, McKay NS, Boerwinkle AH, Kennedy J, Flores S, Handen BL, Christian BT, Head E, Mapstone M, Rafii MS, O'Bryant SE, Price JC, Laymon CM, Krinsky-McHale SJ, Lai F, Rosas HD, Hartley SL, Zaman S, Lott IT, Tudorascu D, Zammit M, Brickman AM, Lee JH, Bird TD, Cohen A, Chrem P, Daniels A, Chhatwal JP, Cruchaga C, Ibanez L, Jucker M, Karch CM, Day GS, Lee JH, Levin J, Llibre-Guerra J, Li Y, Lopera F, Roh JH, Ringman JM, Supnet-Bell C, van Dyck CH, Xiong C, Wang G, Morris JC, McDade E, Bateman RJ, Benzinger TLS, Gordon BA, Ances BM; Alzheimer's Biomarker Consortium-Down syndrome; Dominantly Inherited Alzheimer Network. Wisch JK, et al. Among authors: christian bt. Lancet Neurol. 2024 May;23(5):500-510. doi: 10.1016/S1474-4422(24)00084-X. Lancet Neurol. 2024. PMID: 38631766
Cognitive and functional performance and plasma biomarkers of early Alzheimer's disease in Down syndrome.
Schworer EK, Handen BL, Petersen M, O'Bryant S, Peven JC, Tudorascu DL, Lee L, Krinsky-McHale SJ, Hom CL, Clare ICH, Christian BT, Schupf N, Lee JH, Head E, Mapstone M, Lott I, Ances BM, Zaman S, Brickman AM, Lai F, Rosas HD, Hartley SL; Alzheimer Biomarker Consortium‐Down Syndrome. Schworer EK, et al. Among authors: christian bt. Alzheimers Dement (Amst). 2024 Apr 14;16(2):e12582. doi: 10.1002/dad2.12582. eCollection 2024 Apr-Jun. Alzheimers Dement (Amst). 2024. PMID: 38623384 Free PMC article.
193 results