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Halofuginone for non-hospitalized adult patients with COVID-19 a multicenter, randomized placebo-controlled phase 2 trial. The HALOS trial.
Tomazini BM, Tramujas L, Medrado FA Junior, Gomes SPDC, Negrelli KL, Murinize GS, Santos RHN, Vianna BMP, Piotto BF, Veiga TS, Santos BRD, Peneluppi Horak AC, Lemos OMC, Lopes MA, Olicheski BB, Campones DL, Peixoto LAA, Basilio ADAC, Gebara OCE, Lopes ATA, Saconato H, Valeis N, Miranda TA, Laranjeira LN, Santucci EV, Carlin AF, Esko JD, Gordts PLSM, Tsimikas S, Cavalcanti AB. Tomazini BM, et al. Among authors: esko jd. PLoS One. 2024 Feb 23;19(2):e0299197. doi: 10.1371/journal.pone.0299197. eCollection 2024. PLoS One. 2024. PMID: 38394069 Free PMC article. Clinical Trial.
Diversity of human salivary heparan sulfate.
Spliid CB, Mehta S, Fuster MM, Martino C, Morris CL, Lee N, Florentino I, Tong K, Liu L, Ackermann G, Knight R, Esko JD, Hurtado de Mendoza T. Spliid CB, et al. Among authors: esko jd. Glycobiology. 2024 Dec 10;34(12):cwae084. doi: 10.1093/glycob/cwae084. Glycobiology. 2024. PMID: 39361890
SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling.
Biering SB, de Sousa FTG, Tjang LV, Pahmeier F, Ruan R, Blanc SF, Patel TS, Worthington CM, Glasner DR, Castillo-Rojas B, Servellita V, Lo NTN, Wong MP, Warnes CM, Sandoval DR, Clausen TM, Santos YA, Ortega V, Aguilar HC, Esko JD, Chui CY, Pak JE, Beatty PR, Harris E. Biering SB, et al. Among authors: esko jd. bioRxiv [Preprint]. 2021 Dec 13:2021.12.10.472112. doi: 10.1101/2021.12.10.472112. bioRxiv. 2021. Update in: Nat Commun. 2022 Dec 9;13(1):7630. doi: 10.1038/s41467-022-34910-5 PMID: 34931188 Free PMC article. Updated. Preprint.
Alteration of Neuropilin-1 and Heparan Sulfate Interaction Impairs Murine B16 Tumor Growth.
Painter CD, Sankaranarayanan NV, Nagarajan B, Mandel Clausen T, West AMV, Setiawan NJ, Park J, Porell RN, Bartels PL, Sandoval DR, Vasquez GJ, Chute JP, Godula K, Vander Kooi CW, Gordts PLSM, Corbett KD, Termini CM, Desai UR, Esko JD. Painter CD, et al. Among authors: esko jd. ACS Chem Biol. 2024 Aug 16;19(8):1820-1835. doi: 10.1021/acschembio.4c00389. Epub 2024 Aug 4. ACS Chem Biol. 2024. PMID: 39099090 Free PMC article.
B3GALT6 promotes dormant breast cancer cell survival and recurrence by enabling heparan sulfate-mediated FGF signaling.
Sreekumar A, Lu M, Choudhury B, Pan TC, Pant DK, Lawrence-Paul MR, Sterner CJ, Belka GK, Toriumi T, Benz BA, Escobar-Aguirre M, Marino FE, Esko JD, Chodosh LA. Sreekumar A, et al. Among authors: esko jd. Cancer Cell. 2024 Jan 8;42(1):52-69.e7. doi: 10.1016/j.ccell.2023.11.008. Epub 2023 Dec 7. Cancer Cell. 2024. PMID: 38065100 Free PMC article.
Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection.
Aguilar-Calvo P, Malik A, Sandoval DR, Barback C, Orrù CD, Standke HG, Thomas OR, Dwyer CA, Pizzo DP, Bapat J, Soldau K, Ogawa R, Riley MB, Nilsson KPR, Kraus A, Caughey B, Iliff JJ, Vera DR, Esko JD, Sigurdson CJ. Aguilar-Calvo P, et al. Among authors: esko jd. PLoS Pathog. 2023 Sep 25;19(9):e1011487. doi: 10.1371/journal.ppat.1011487. eCollection 2023 Sep. PLoS Pathog. 2023. PMID: 37747931 Free PMC article.
Malaria Biomimetic for Tumor Targeted Drug Delivery.
Pihl J, Clausen TM, Zhou J, Krishnan N, Ørum-Madsen MS, Gustavsson T, Dagil R, Daugaard M, Choudhary S, Foged C, Esko JD, Zhang L, Fang RH, Salanti A. Pihl J, et al. Among authors: esko jd. ACS Nano. 2023 Jul 25;17(14):13500-13509. doi: 10.1021/acsnano.3c01910. Epub 2023 Jul 12. ACS Nano. 2023. PMID: 37435892
Signalling by senescent melanocytes hyperactivates hair growth.
Wang X, Ramos R, Phan AQ, Yamaga K, Flesher JL, Jiang S, Oh JW, Jin S, Jahid S, Kuan CH, Nguyen TK, Liang HY, Shettigar NU, Hou R, Tran KH, Nguyen A, Vu KN, Phung JL, Ingal JP, Levitt KM, Cao X, Liu Y, Deng Z, Taguchi N, Scarfone VM, Wang G, Paolilli KN, Wang X, Guerrero-Juarez CF, Davis RT, Greenberg EN, Ruiz-Vega R, Vasudeva P, Murad R, Widyastuti LHP, Lee HL, McElwee KJ, Gadeau AP, Lawson DA, Andersen B, Mortazavi A, Yu Z, Nie Q, Kunisada T, Karin M, Tuckermann J, Esko JD, Ganesan AK, Li J, Plikus MV. Wang X, et al. Among authors: esko jd. Nature. 2023 Jun;618(7966):808-817. doi: 10.1038/s41586-023-06172-8. Epub 2023 Jun 21. Nature. 2023. PMID: 37344645 Free PMC article.
331 results