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Sequence-Dependent Liquid Crystalline Ordering of Gapped DNA.
Kodikara SG, Gleeson JT, Jakli A, Sprunt S, Balci H. Kodikara SG, et al. ACS Macro Lett. 2025 Jan 22:149-154. doi: 10.1021/acsmacrolett.4c00788. Online ahead of print. ACS Macro Lett. 2025. PMID: 39843394
While samples with mixed sequence form layered (smectic) phases, poly-A samples demonstrate a columnar phase at lower temperatures (5-35 C), not previously observed in GDNA samples, and a smectic-B phase of exceptional stability at higher temperatures (35-65 C). We …
While samples with mixed sequence form layered (smectic) phases, poly-A samples demonstrate a columnar phase at lower temperat …
Numerous rRNA molecules form the apicomplexan mitoribosome via repurposed protein and RNA elements.
Shikha S, Tobiasson V, Ferreira Silva M, Ovciarikova J, Beraldi D, Mühleip A, Sheiner L. Shikha S, et al. Nat Commun. 2025 Jan 18;16(1):817. doi: 10.1038/s41467-025-56057-9. Nat Commun. 2025. PMID: 39827269 Free PMC article.
Here, we use cryo-EM to discover the features that enable this unusual mitoribosome to perform its function. We reveal that poly-A tails added to rRNA molecules are integrated into the ribosome, and we demonstrate their essentiality for mitoribosome formation and fo …
Here, we use cryo-EM to discover the features that enable this unusual mitoribosome to perform its function. We reveal that poly-A …
Solution-phase nucleic acid reaction weaves interfacial barriers on unmodified electrodes: Just-in-time generation of sensor interface for convenient and highly sensitive bioassays.
Jie H, Fan D, Ye H, Lv X, Wu C, Zhuang J. Jie H, et al. Talanta. 2025 Jan 13;287:127589. doi: 10.1016/j.talanta.2025.127589. Online ahead of print. Talanta. 2025. PMID: 39826469
These fragments were then extended by terminal deoxynucleotidyl transferase (TdT) to form long poly(A) tails. The extended products hybridized with a thiolated assembly probe rich in thymine bases and subsequently assembled on the unmodified gold electrode (AuE) sur …
These fragments were then extended by terminal deoxynucleotidyl transferase (TdT) to form long poly(A) tails. The extended pro …
Knockdown of CNOT3, a subunit of the CCR4-NOT deadenylase complex, sensitizes A549 human non-small cell lung cancer cells to senescence-inducing stimuli.
Maipas A, Sato A, Moriyama Y, Yamamoto T, Kono K. Maipas A, et al. Biochem Biophys Res Commun. 2025 Jan 7;748:151294. doi: 10.1016/j.bbrc.2025.151294. Online ahead of print. Biochem Biophys Res Commun. 2025. PMID: 39823890 Free article.
Here, we show that the downregulation of CNOT3, a subunit of the CCR4-NOT complex that deadenylates mRNA poly(A) tails, promotes cellular senescence in subpopulation of A549 human non-small cell lung cancer cells. ...
Here, we show that the downregulation of CNOT3, a subunit of the CCR4-NOT complex that deadenylates mRNA poly(A) tails, promot …
Identification of rare and pathogenic TAL2 gene mutations in B-lineage acute lymphoblastic leukemia (B-ALL) using mutational screening and comprehensive bioinformatics analysis.
Khormizi FZ, Saadi HF, Khatami M, Heidari MM, Tabrizi F, Hashemi A, Khanjarpanah Z. Khormizi FZ, et al. Mol Biol Rep. 2025 Jan 16;52(1):125. doi: 10.1007/s11033-025-10229-4. Mol Biol Rep. 2025. PMID: 39821746
Moreover, a multiple nucleotide deletion (g.659_668del) was found in the 3'UTR in most patients. This deletion occurs at the site of poly-A tail attachment and appears to have significant implications. CONCLUSIONS: These findings offer new insights into the impact o …
Moreover, a multiple nucleotide deletion (g.659_668del) was found in the 3'UTR in most patients. This deletion occurs at the site of poly …
Impact of rare non-coding variants on human diseases through alternative polyadenylation outliers.
Zou X, Zhao Z, Chen Y, Xiong K, Wang Z, Chen S, Chen H, Wei GH, Xu S, Li W, Ni T, Li L. Zou X, et al. Nat Commun. 2025 Jan 16;16(1):682. doi: 10.1038/s41467-024-55407-3. Nat Commun. 2025. PMID: 39819850 Free PMC article.
These aOutliers exhibit unique characteristics from transcription or splicing outliers, with a pronounced RV enrichment. Mechanistically, aOutlier-RVs alter poly(A) signals and splicing sites, and perturbation indeed triggers APA events. Furthermore, we developed a …
These aOutliers exhibit unique characteristics from transcription or splicing outliers, with a pronounced RV enrichment. Mechanistically, aO …
Manipulation of mitochondrial poly(A) polymerase family proteins in Trypanosoma brucei impacts mRNA termini processing.
Smoniewski CM, Mirzavand Borujeni P, Hampton M, Petersen A, Faacks SP, Salavati R, Zimmer SL. Smoniewski CM, et al. Front Parasitol. 2024 Jan 11;2:1298561. doi: 10.3389/fpara.2023.1298561. eCollection 2023. Front Parasitol. 2024. PMID: 39816830 Free PMC article.
Two noncanonical rNTRs that are thought to be poly(A) polymerases (PAPs) have been identified in the mitochondria of trypanosomes - KPAP1 and KPAP2. ...
Two noncanonical rNTRs that are thought to be poly(A) polymerases (PAPs) have been identified in the mitochondria of trypanoso …
Cytoplasmic Regulation of the Poly(A) Tail Length as a Potential Therapeutic Target.
Fernandez M, Mendez R. Fernandez M, et al. RNA. 2025 Jan 13:rna.080333.124. doi: 10.1261/rna.080333.124. Online ahead of print. RNA. 2025. PMID: 39805658 Free article.
Virtually all mRNAs acquire a poly(A) tail co-transcriptionally, but its length is dynamically regulated in the cytoplasm in a transcript-specific manner. The length of the poly(A) tail plays a crucial role in determining mRNA translation, stability, a …
Virtually all mRNAs acquire a poly(A) tail co-transcriptionally, but its length is dynamically regulated in the cytoplasm in a …
Design of a Multiepitope Pan-Proteomic mRNA Vaccine Construct Against African Swine Fever Virus: A Reverse Vaccinology Approach.
Sira EMJS, Fajardo LE, Banico EC, Odchimar NMO, Orosco FL. Sira EMJS, et al. Vet Med Int. 2025 Jan 4;2025:2638167. doi: 10.1155/vmi/2638167. eCollection 2025. Vet Med Int. 2025. PMID: 39803351 Free PMC article.
A 50S ribosomal L7/L12 protein adjuvant, 5' cap, poly(A) tail, signal peptide, and MHC-I-targeting domain were incorporated into the design using appropriate linkers to increase immunogenicity, stability, and recognition efficiency. ...
A 50S ribosomal L7/L12 protein adjuvant, 5' cap, poly(A) tail, signal peptide, and MHC-I-targeting domain were incorporated in …
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