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CDK12 loss drives prostate cancer progression, transcription-replication conflicts, and synthetic lethality with paralog CDK13.
Tien JC, Luo J, Chang Y, Zhang Y, Cheng Y, Wang X, Yang J, Mannan R, Mahapatra S, Shah P, Wang XM, Todd AJ, Eyunni S, Cheng C, Rebernick RJ, Xiao L, Bao Y, Neiswender J, Brough R, Pettitt SJ, Cao X, Miner SJ, Zhou L, Wu YM, Labanca E, Wang Y, Parolia A, Cieslik M, Robinson DR, Wang Z, Feng FY, Chou J, Lord CJ, Ding K, Chinnaiyan AM. Tien JC, et al. Among authors: parolia a. Cell Rep Med. 2024 Oct 15;5(10):101758. doi: 10.1016/j.xcrm.2024.101758. Epub 2024 Oct 4. Cell Rep Med. 2024. PMID: 39368479 Free PMC article.
NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis.
Parolia A, Eyunni S, Verma BK, Young E, Liu Y, Liu L, George J, Aras S, Das CK, Mannan R, Ur Rasool R, Mitchell-Velasquez E, Mahapatra S, Luo J, Carson SE, Xiao L, Gajjala PR, Venkatesh S, Jaber M, Wang X, He T, Qiao Y, Pang M, Zhang Y, Tien JC, Louw M, Alhusayan M, Cao X, Su F, Tavana O, Hou C, Wang Z, Ding K, Chinnaiyan AM, Asangani IA. Parolia A, et al. Nat Genet. 2024 Oct;56(10):2132-2143. doi: 10.1038/s41588-024-01893-6. Epub 2024 Sep 9. Nat Genet. 2024. PMID: 39251788 Free PMC article.
Insights on Future Directions in Cancer Research from the AACR NextGen Stars.
Cañadas I, Casirati G, Houlahan KE, Maxwell KN, Mehta A, Parolia A, Saulnier O, Taylor AM, Thomas CE, Vázquez-García I. Cañadas I, et al. Among authors: parolia a. Cancer Discov. 2024 Sep 4;14(9):1584-1589. doi: 10.1158/2159-8290.CD-24-0774. Cancer Discov. 2024. PMID: 39228299 No abstract available.
Targeting the mSWI/SNF complex in POU2F-POU2AF transcription factor-driven malignancies.
He T, Xiao L, Qiao Y, Klingbeil O, Young E, Wu XS, Mannan R, Mahapatra S, Redin E, Cho H, Bao Y, Kandarpa M, Ching-Yi Tien J, Wang X, Eyunni S, Zheng Y, Kim N, Zheng H, Hou S, Su F, Miner SJ, Mehra R, Cao X, Abbineni C, Samajdar S, Ramachandra M, Dhanasekaran SM, Talpaz M, Parolia A, Rudin CM, Vakoc CR, Chinnaiyan AM. He T, et al. Among authors: parolia a. Cancer Cell. 2024 Aug 12;42(8):1336-1351.e9. doi: 10.1016/j.ccell.2024.06.006. Epub 2024 Jul 18. Cancer Cell. 2024. PMID: 39029462 Free article.
Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance.
Yu J, Yan Y, Li S, Xu Y, Parolia A, Rizvi S, Wang W, Zhai Y, Xiao R, Li X, Liao P, Zhou J, Okla K, Lin H, Lin X, Grove S, Wei S, Vatan L, Hu J, Szumilo J, Kotarski J, Freeman ZT, Skala S, Wicha M, Cho KR, Chinnaiyan AM, Schon S, Wen F, Kryczek I, Wang S, Chen L, Zou W. Yu J, et al. Among authors: parolia a. Cell. 2024 Aug 22;187(17):4713-4732.e19. doi: 10.1016/j.cell.2024.06.012. Epub 2024 Jul 4. Cell. 2024. PMID: 38968937 Free article.
PIKfyve, expressed by CD11c-positive cells, controls tumor immunity.
Choi JE, Qiao Y, Kryczek I, Yu J, Gurkan J, Bao Y, Gondal M, Tien JC, Maj T, Yazdani S, Parolia A, Xia H, Zhou J, Wei S, Grove S, Vatan L, Lin H, Li G, Zheng Y, Zhang Y, Cao X, Su F, Wang R, He T, Cieslik M, Green MD, Zou W, Chinnaiyan AM. Choi JE, et al. Among authors: parolia a. Nat Commun. 2024 Jun 28;15(1):5487. doi: 10.1038/s41467-024-48931-9. Nat Commun. 2024. PMID: 38942798 Free PMC article.
Deciphering the Transcription Factor Landscape in Neuroendocrine Prostate Cancer Progression: A Novel Approach to Understand NE Transdifferentiation.
Wang Y, Xue H, Zhu X, Lin D, Dong X, Chen Z, Chen J, Shi M, Ni Y, Cao J, Wu R, Kang N, Pang X, Crea F, Lin YY, Collins CC, Gleave ME, Parolia A, Chinnaiyan A, Ong CJ, Wang Y. Wang Y, et al. Among authors: parolia a. bioRxiv [Preprint]. 2024 Apr 29:2024.04.27.591428. doi: 10.1101/2024.04.27.591428. bioRxiv. 2024. PMID: 38746377 Free PMC article. Preprint.
107 results