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The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination.
Gharibani P, Abramson E, Shanmukha S, Smith MD, Godfrey WH, Lee JJ, Hu J, Baydyuk M, Dorion MF, Deng X, Guo Y, Calle AJ, A Hwang S, Huang JK, Calabresi PA, Kornberg MD, Kim PM. Gharibani P, et al. Among authors: calle aj. Sci Transl Med. 2025 Jan 8;17(780):eadk3434. doi: 10.1126/scitranslmed.adk3434. Epub 2025 Jan 8. Sci Transl Med. 2025. PMID: 39772770