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Page 1
Combination therapies of porcupine inhibition with ruxolitinib, ibrutinib or belumosudil in murine sclerodermatous GvHD.
Hong X, Xiao Y, Xu L, Shen L, Neelagar R, Devakumar V, Trinh-Minh T, Liang M, Rius Rigau A, Zhang Y, Li YN, Dees C, Györfi AH, Wolff D, Herr W, Schett G, Distler JHW, Matei AE. Hong X, et al. Among authors: dees c. Blood Adv. 2025 Jan 7:bloodadvances.2024014387. doi: 10.1182/bloodadvances.2024014387. Online ahead of print. Blood Adv. 2025. PMID: 39775728 No abstract available.
Targeting of canonical WNT signaling ameliorates experimental sclerodermatous chronic graft-versus-host disease.
Zhang Y, Shen L, Dreißigacker K, Zhu H, Trinh-Minh T, Meng X, Tran-Manh C, Dees C, Matei AE, Chen CW, Ditschkowski M, Krauss S, Winkler J, Wolff D, Ziemer M, Beilhack A, Karrer S, Herr W, Mackensen A, Schett G, Spriewald BM, Distler JHW. Zhang Y, et al. Among authors: dees c. Blood. 2021 Apr 29;137(17):2403-2416. doi: 10.1182/blood.2020008720. Blood. 2021. PMID: 33529322 Free article.
Cellular and molecular mechanisms in fibrosis.
Dees C, Chakraborty D, Distler JHW. Dees C, et al. Exp Dermatol. 2021 Jan;30(1):121-131. doi: 10.1111/exd.14193. Epub 2020 Oct 9. Exp Dermatol. 2021. PMID: 32931037 Review.
Mutual Amplification of GLI2/Hedgehog and Transcription Factor JUN/AP-1 Signaling in Fibroblasts in Systemic Sclerosis: Potential Implications for Combined Therapies.
Bergmann C, Chenguiti Fakhouri S, Trinh-Minh T, Filla T, Rius Rigau A, Ekici AB, Merlevede B, Hallenberger L, Zhu H, Dees C, Matei AE, Auth J, Györfi AH, Zhou X, Rauber S, Bozec A, Dickel N, Liang C, Kunz M, Schett G, Distler JHW. Bergmann C, et al. Among authors: dees c. Arthritis Rheumatol. 2025 Jan;77(1):92-98. doi: 10.1002/art.42979. Epub 2024 Oct 20. Arthritis Rheumatol. 2025. PMID: 39187464 Free PMC article.
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis.
Zehender A, Huang J, Györfi AH, Matei AE, Trinh-Minh T, Xu X, Li YN, Chen CW, Lin J, Dees C, Beyer C, Gelse K, Zhang ZY, Bergmann C, Ramming A, Birchmeier W, Distler O, Schett G, Distler JHW. Zehender A, et al. Among authors: dees c. Nat Commun. 2018 Aug 14;9(1):3259. doi: 10.1038/s41467-018-05768-3. Nat Commun. 2018. PMID: 30108215 Free PMC article.
PGC-1α regulates autophagy to promote fibroblast activation and tissue fibrosis.
Zhang Y, Shen L, Zhu H, Dreissigacker K, Distler D, Zhou X, Györfi AH, Bergmann C, Meng X, Dees C, Trinh-Minh T, Ludolph I, Horch R, Ramming A, Schett G, Distler JHW. Zhang Y, et al. Among authors: dees c. Ann Rheum Dis. 2020 Sep;79(9):1227-1233. doi: 10.1136/annrheumdis-2020-216963. Epub 2020 Jun 1. Ann Rheum Dis. 2020. PMID: 32482644
Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis.
Chakraborty D, Zhu H, Jüngel A, Summa L, Li YN, Matei AE, Zhou X, Huang J, Trinh-Minh T, Chen CW, Lafyatis R, Dees C, Bergmann C, Soare A, Luo H, Ramming A, Schett G, Distler O, Distler JHW. Chakraborty D, et al. Among authors: dees c. Sci Transl Med. 2020 Sep 30;12(563):eaaz5506. doi: 10.1126/scitranslmed.aaz5506. Sci Transl Med. 2020. PMID: 32998972
156 results