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Page 1
GPR182 is an endothelium-specific atypical chemokine receptor that maintains hematopoietic stem cell homeostasis.
Le Mercier A, Bonnavion R, Yu W, Alnouri MW, Ramas S, Zhang Y, Jäger Y, Roquid KA, Jeong HW, Sivaraj KK, Cho H, Chen X, Strilic B, Sijmonsma T, Adams R, Schroeder T, Rieger MA, Offermanns S. Le Mercier A, et al. Among authors: alnouri mw. Proc Natl Acad Sci U S A. 2021 Apr 27;118(17):e2021596118. doi: 10.1073/pnas.2021596118. Proc Natl Acad Sci U S A. 2021. PMID: 33875597 Free PMC article.
Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far?
Schebb NH, Kühn H, Kahnt AS, Rund KM, O'Donnell VB, Flamand N, Peters-Golden M, Jakobsson PJ, Weylandt KH, Rohwer N, Murphy RC, Geisslinger G, FitzGerald GA, Hanson J, Dahlgren C, Alnouri MW, Offermanns S, Steinhilber D. Schebb NH, et al. Among authors: alnouri mw. Front Pharmacol. 2022 Mar 2;13:838782. doi: 10.3389/fphar.2022.838782. eCollection 2022. Front Pharmacol. 2022. PMID: 35308198 Free PMC article. Review.
A succinate/SUCNR1-brush cell defense program in the tracheal epithelium.
Perniss A, Boonen B, Tonack S, Thiel M, Poharkar K, Alnouri MW, Keshavarz M, Papadakis T, Wiegand S, Pfeil U, Richter K, Althaus M, Oberwinkler J, Schütz B, Boehm U, Offermanns S, Leinders-Zufall T, Zufall F, Kummer W. Perniss A, et al. Among authors: alnouri mw. Sci Adv. 2023 Aug 2;9(31):eadg8842. doi: 10.1126/sciadv.adg8842. Epub 2023 Aug 2. Sci Adv. 2023. PMID: 37531421 Free PMC article.
Identification of a Chemical Probe for BLT2 Activation by Scaffold Hopping.
Hernandez-Olmos V, Heering J, Ildefeld N, Ehrler JHM, Kaps A, Rajkumar R, Marinescu B, Kaiser A, Macinkovic I, Elewa MAF, Alnouri MW, Elson L, Schubert-Zsilavecz M, Kallenborn-Gerhardt W, Schmidtko A, Müller S, Offermanns S, Steinhilber D, Weigert A, Proschak E. Hernandez-Olmos V, et al. Among authors: alnouri mw. J Med Chem. 2025 Jan 23;68(2):1195-1221. doi: 10.1021/acs.jmedchem.4c01617. Epub 2025 Jan 13. J Med Chem. 2025. PMID: 39803894
SPMs exert anti-inflammatory and pro-resolving effects through positive allosteric modulation of the prostaglandin EP4 receptor.
Alnouri MW, Roquid KA, Bonnavion R, Cho H, Heering J, Kwon J, Jäger Y, Wang S, Günther S, Wettschureck N, Geisslinger G, Gurke R, Müller CE, Proschak E, Offermanns S. Alnouri MW, et al. Proc Natl Acad Sci U S A. 2024 Oct 8;121(41):e2407130121. doi: 10.1073/pnas.2407130121. Epub 2024 Oct 4. Proc Natl Acad Sci U S A. 2024. PMID: 39365815 Free PMC article.
Development of a Potent and Selective G2A (GPR132) Agonist.
Hernandez-Olmos V, Heering J, Marinescu B, Schermeng T, Ivanov VV, Moroz YS, Nevermann S, Mathes M, Ehrler JHM, Alnouri MW, Wolf M, Haydo AS, Schmachtel T, Zaliani A, Höfner G, Kaiser A, Schubert-Zsilavecz M, Beck-Sickinger AG, Offermanns S, Gribbon P, Rieger MA, Merk D, Sisignano M, Steinhilber D, Proschak E. Hernandez-Olmos V, et al. Among authors: alnouri mw. J Med Chem. 2024 Jul 11;67(13):10567-10588. doi: 10.1021/acs.jmedchem.3c02164. Epub 2024 Jun 25. J Med Chem. 2024. PMID: 38917049
Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction.
Wang T, Shao J, Kumar S, Alnouri MW, Carvalho J, Günther S, Krasel C, Murphy KT, Bünemann M, Offermanns S, Wettschureck N. Wang T, et al. Among authors: alnouri mw. Circ Res. 2024 May 10;134(10):1259-1275. doi: 10.1161/CIRCRESAHA.123.323752. Epub 2024 Apr 10. Circ Res. 2024. PMID: 38597112
13 results