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Safety of topical estrogen therapy during adjuvant endocrine treatment among patients with breast cancer: A meta-analysis based expert panel discussion.
Kastora SL, Pantiora E, Hong YH, Veeramani M, Azim HA Jr, Chakrabarti R, Geisler J, Knoop A, Lambertini M, Linderholm B, Meattini I, Partridge AH, Vaz-Luis I, Vorburger D, Yongue G, Karakatsanis A, Valachis A. Kastora SL, et al. Cancer Treat Rev. 2025 Jan 17;133:102880. doi: 10.1016/j.ctrv.2025.102880. Online ahead of print. Cancer Treat Rev. 2025. PMID: 39854791 Review.
Regioselective 1,4-Addition of P(O)-H Species to In Situ-Formed 1-Benzopyrylium Ion from C3-Substituted 2H-Chromene Hemiketals to Construct C3-Functionalized C4-Phosphorylated 4H-Chromenes.
Wen Z, Wang B, Zhao MT, Yang KC, Ni HL, Chen L. Wen Z, et al. J Org Chem. 2025 Jan 24. doi: 10.1021/acs.joc.4c02113. Online ahead of print. J Org Chem. 2025. PMID: 39854769
In total, the reaction features the use of inexpensive Zn(ClO(4))(2).6H(2)O as a catalyst, low catalyst loading (only 5 mol %), mild reaction conditions (60 C, 10 min to 24 h), and broad substrate scope (46 examples) as well as good to high yields (>90% yield on average …
In total, the reaction features the use of inexpensive Zn(ClO(4))(2).6H(2)O as a catalyst, low catalyst loading (only 5 mol %), mild reactio …
Three cases of hemoglobin M disease in a family lineage: Case report and literature review.
Shen Y, Wang Y, Xue L, Li C, He L, Wu S. Shen Y, et al. Medicine (Baltimore). 2025 Jan 24;104(4):e40652. doi: 10.1097/MD.0000000000040652. Medicine (Baltimore). 2025. PMID: 39854759 Review.
INTERVENTIONS: The patient was treated with vitamin C. OUTCOMES: Genetic testing revealed that the patient and her mother carried the c.190C > T mutation, leading to the p.H63Y amino acid change linked to the methemoglobin (MetHb) mutation. Despite undergoing vit …
INTERVENTIONS: The patient was treated with vitamin C. OUTCOMES: Genetic testing revealed that the patient and her mother carried the …
The role of inflammatory factors in mediating the causal effects of type 1 diabetes mellitus on idiopathic pulmonary fibrosis: A two-step Mendelian randomization study.
Fan Q, Meng Y, Nie Z, Yi Z, Chen L, Xie S. Fan Q, et al. Medicine (Baltimore). 2025 Jan 24;104(4):e41320. doi: 10.1097/MD.0000000000041320. Medicine (Baltimore). 2025. PMID: 39854757
Further mediation analysis showed that this effect was partly mediated by increasing C-X-C motif chemokine ligand 10 (CXCL10) and interleukin-12 subunit beta (IL-12B). In conclusion, T1DM is related to an increased risk of IPF. ...
Further mediation analysis showed that this effect was partly mediated by increasing C-X-C motif chemokine ligand 10 (CXCL10) …
Adjuvant radiation improves survival outcomes in adrenocortical carcinoma: A population-based study.
Zhan K, Ruan X, Jia H. Zhan K, et al. Medicine (Baltimore). 2025 Jan 24;104(4):e41313. doi: 10.1097/MD.0000000000041313. Medicine (Baltimore). 2025. PMID: 39854744
The area under the receiver operating characteristic curve values for 1-, 3-, and 5-year OS were 0.85, 0.818, and 0.814, respectively, and for CSS, they were 0.839, 0.803, and 0.796, respectively. C-indices were 0.756 and 0.749 for OS and CSS, respectively, indicating that …
The area under the receiver operating characteristic curve values for 1-, 3-, and 5-year OS were 0.85, 0.818, and 0.814, respectively, and f …
A review of cutting-edge biomarkers for diagnosing coronary artery disease.
Azami P, Mohammadzadeh S, Seirafi S, Razeghian-Jahromi I. Azami P, et al. Medicine (Baltimore). 2025 Jan 24;104(4):e41377. doi: 10.1097/MD.0000000000041377. Medicine (Baltimore). 2025. PMID: 39854741 Review.
In this regard, prominent biomarkers including Tenascin-C, IL-37, PTX3, transthyretin, soluble interleukin-6 receptor alpha, and miR-15a are identified as having high diagnostic potential for chronic CAD that indeed showcase promising performance metrics. ...
In this regard, prominent biomarkers including Tenascin-C, IL-37, PTX3, transthyretin, soluble interleukin-6 receptor alpha, and miR- …
The roles of STAT1, CASP8, and MYD88 in the care of ischemic stroke.
Qin X, Li S, Huang X. Qin X, et al. Medicine (Baltimore). 2025 Jan 24;104(4):e41396. doi: 10.1097/MD.0000000000041396. Medicine (Baltimore). 2025. PMID: 39854740
A total of 1183 DEGs were obtained, which were mainly concentrated in immune effector processes, cell activation, and protein serine/threonine kinase activity, the NOD-like receptor signaling pathway, NF-kappa B signaling pathway, C-type lectin receptor signaling pathway, …
A total of 1183 DEGs were obtained, which were mainly concentrated in immune effector processes, cell activation, and protein serine/threoni …
Correlative Raman-Voltage Microscopy Revealing the Localized Structure-Stress Relationship in Silicon Solar Cells.
Lan T, Zhao T, Liu Y, Cao J, Li W, Yang J, Zhang X, Wang Y, Sun B. Lan T, et al. ACS Nano. 2025 Jan 24. doi: 10.1021/acsnano.4c13688. Online ahead of print. ACS Nano. 2025. PMID: 39854730
The localized stresses cause significant electrical output degradation in c-Si solar cells. In addition, theoretical simulations and experimental characterization indicate that the etched rear side acts as a more intense stress concentrator, resulting in an asymmetrical st …
The localized stresses cause significant electrical output degradation in c-Si solar cells. In addition, theoretical simulations and …
DDAVP response and its determinants in bleeding disorders: a systematic review and meta-analysis.
Laan SNJ, Del Castillo J, Cannegieter SC, Fijnvandraat K Prof, Kruip MJHA, le Cessie S, Bierings R, Eikenboom JCJ, van Moort I. Laan SNJ, et al. Blood. 2025 Jan 24:blood.2024026804. doi: 10.1182/blood.2024026804. Online ahead of print. Blood. 2025. PMID: 39854691
Meta-analysis showed a pooled response proportion of 0.71 [0.64;0.78] and a significant difference in response between disease subtypes. For hemophilia A, baseline FVIII:C was a borderline significant determinant of response. In von Willebrand disease (VWD) type 1 patients …
Meta-analysis showed a pooled response proportion of 0.71 [0.64;0.78] and a significant difference in response between disease subtypes. For …
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