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TAK-994 Mechanistic Investigation into Drug-Induced Liver Injury.
Shinozawa T, Miyamoto K, Baker KS, Faber SC, Flores R, Uetrecht J, von Hehn C, Yukawa T, Tohyama K, Kadali H, von Grotthuss M, Sudo Y, Smith EN, Diogo D, Zhu AZX, Dragan Y, Cebers G, Wagoner MP. Shinozawa T, et al. Among authors: tohyama k. Toxicol Sci. 2025 Jan 9:kfaf003. doi: 10.1093/toxsci/kfaf003. Online ahead of print. Toxicol Sci. 2025. PMID: 39786842
Drug transporters in drug disposition - highlights from the year 2023.
Chothe PP, Argikar UA, Mitra P, Nakakariya M, Ramsden D, Rotter CJ, Sandoval P, Tohyama K. Chothe PP, et al. Among authors: tohyama k. Drug Metab Rev. 2024 Nov;56(4):318-348. doi: 10.1080/03602532.2024.2399523. Epub 2024 Sep 11. Drug Metab Rev. 2024. PMID: 39221672 Review.
Inhibition of TOPORS ubiquitin ligase augments the efficacy of DNA hypomethylating agents through DNMT1 stabilization.
Kaito S, Aoyama K, Oshima M, Tsuchiya A, Miyota M, Yamashita M, Koide S, Nakajima-Takagi Y, Kozuka-Hata H, Oyama M, Yogo T, Yabushita T, Ito R, Ueno M, Hirao A, Tohyama K, Li C, Kawabata KC, Yamaguchi K, Furukawa Y, Kosako H, Yoshimi A, Goyama S, Nannya Y, Ogawa S, Agger K, Helin K, Yamazaki S, Koseki H, Doki N, Harada Y, Harada H, Nishiyama A, Nakanishi M, Iwama A. Kaito S, et al. Among authors: tohyama k. Nat Commun. 2024 Aug 28;15(1):7359. doi: 10.1038/s41467-024-50498-4. Nat Commun. 2024. PMID: 39198387 Free PMC article.
Survey of Pharmaceutical Industry's Best Practices around In Vitro Transporter Assessment and Implications for Drug Development: Considerations from the International Consortium for Innovation and Quality for Pharmaceutical Development Transporter Working Group.
Rollison HE, Mitra P, Chanteux H, Fang Z, Liang X, Park SH, Costales C, Hanna I, Thakkar N, Vergis JM, Bow DAJ, Hillgren KM, Brumm J, Chu X, Hop CECA, Lai Y, Li CY, Mahar KM, Salphati L, Sane R, Shen H, Taskar K, Taub M, Tohyama K, Xu C, Fenner KS. Rollison HE, et al. Among authors: tohyama k. Drug Metab Dispos. 2024 Jun 17;52(7):582-596. doi: 10.1124/dmd.123.001587. Drug Metab Dispos. 2024. PMID: 38697852
Clinical impact and characteristics of erythroid dysplasia in adult aplastic anaemia: Results from a multicentre registry.
Maeda T, Matsuda A, Kanda J, Kawabata H, Ishikawa T, Tohyama K, Kitanaka A, Araseki K, Shimbo K, Hata T, Suzuki T, Kayano H, Usuki K, Shindo-Ueda M, Arima N, Nohgawa M, Ohta A, Chiba S, Miyazaki Y, Nakao S, Ozawa K, Arai S, Kurokawa M, Takaori-Kondo A, Mitani K; Japanese National Research Group on Idiopathic Bone Marrow Failure Syndromes. Maeda T, et al. Among authors: tohyama k. Br J Haematol. 2024 May;204(5):2086-2096. doi: 10.1111/bjh.19323. Epub 2024 Jan 31. Br J Haematol. 2024. PMID: 38296352
Discovery of a novel series of medium-sized cyclic enteropeptidase inhibitors.
Kikuchi F, Ikeda Z, Kakegawa K, Nishikawa Y, Sasaki S, Fukuda K, Takami K, Banno Y, Nishikawa H, Taya N, Nakahata T, Itono S, Yashiro H, Tsuchimori K, Hiyoshi H, Sasaki M, Tohyama K, Matsumiya K, Ishihara Y, Kawamoto T, Kamaura M, Watanabe M, Kitazaki T, Maekawa T, Sasaki M. Kikuchi F, et al. Among authors: tohyama k. Bioorg Med Chem. 2023 Oct 1;93:117462. doi: 10.1016/j.bmc.2023.117462. Epub 2023 Aug 29. Bioorg Med Chem. 2023. PMID: 37683572 Free article.
Drug transporters in drug disposition - the year 2022 in review.
Chothe PP, Mitra P, Nakakariya M, Ramsden D, Rotter CJ, Sandoval P, Tohyama K. Chothe PP, et al. Among authors: tohyama k. Drug Metab Rev. 2023 Nov;55(4):343-370. doi: 10.1080/03602532.2023.2252618. Epub 2023 Sep 6. Drug Metab Rev. 2023. PMID: 37644867 Review.
Discovery of a Novel Series of Potent, Selective, Orally Available, and Brain-Penetrable C1s Inhibitors for Modulation of the Complement Pathway.
Ikeda Z, Kamei T, Sasaki Y, Reynolds M, Sakai N, Yoshikawa M, Tawada M, Morishita N, Dougan DR, Chen CH, Levin I, Zou H, Kuno M, Arimura N, Kikukawa Y, Kondo M, Tohyama K, Sato K. Ikeda Z, et al. Among authors: tohyama k. J Med Chem. 2023 May 11;66(9):6354-6371. doi: 10.1021/acs.jmedchem.3c00348. Epub 2023 Apr 25. J Med Chem. 2023. PMID: 37120845 Free PMC article.
370 results