Lin CM - Search Results

1

Drug-Linker Constructs Bearing Unique Dual-Mechanism Tubulin Binding Payloads Tethered through Cleavable and Non-Cleavable Linkers.

Ford JW, VanNatta JM, Mondal D, Lin CM, Deng Y, Bai R, Hamel E, Trawick ML, Pinney KG. Ford JW, et al. Among authors: lin cm. Tetrahedron. 2025 Feb 1;171:134350. doi: 10.1016/j.tet.2024.134350. Epub 2024 Nov 6. Tetrahedron. 2025. PMID: 39801742

2

Synthesis of structurally diverse benzosuberene analogues and their biological evaluation as anti-cancer agents.

Tanpure RP, George CS, Strecker TE, Devkota L, Tidmore JK, Lin CM, Herdman CA, Macdonough MT, Sriram M, Chaplin DJ, Trawick ML, Pinney KG. Tanpure RP, et al. Among authors: lin cm. Bioorg Med Chem. 2013 Dec 15;21(24):8019-32. doi: 10.1016/j.bmc.2013.08.035. Epub 2013 Sep 4. Bioorg Med Chem. 2013. PMID: 24183586 Free PMC article.

3

Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents.

Devkota L, Lin CM, Strecker TE, Wang Y, Tidmore JK, Chen Z, Guddneppanavar R, Jelinek CJ, Lopez R, Liu L, Hamel E, Mason RP, Chaplin DJ, Trawick ML, Pinney KG. Devkota L, et al. Among authors: lin cm. Bioorg Med Chem. 2016 Mar 1;24(5):938-956. doi: 10.1016/j.bmc.2016.01.007. Epub 2016 Jan 6. Bioorg Med Chem. 2016. PMID: 26852340 Free PMC article.

4

Interrelationships of tubulin-GDP and tubulin-GTP in microtubule assembly.

Lin CM, Hamel E. Lin CM, et al. Biochemistry. 1987 Nov 3;26(22):7173-82. doi: 10.1021/bi00396a045. Biochemistry. 1987. PMID: 3427067

5

Reexamination of the role of nonhydrolyzable guanosine 5'-triphosphate analogues in tubulin polymerization: reaction conditions are a critical factor for effective interactions at the exchangeable nucleotide site.

Hamel E, Lin CM. Hamel E, et al. Among authors: lin cm. Biochemistry. 1990 Mar 20;29(11):2720-9. doi: 10.1021/bi00463a015. Biochemistry. 1990. PMID: 2346744

6

Identification of the cysteine residue of beta-tubulin alkylated by the antimitotic agent 2,4-dichlorobenzyl thiocyanate, facilitated by separation of the protein subunits of tubulin by hydrophobic column chromatography.

Bai RL, Lin CM, Nguyen NY, Liu TY, Hamel E. Bai RL, et al. Among authors: lin cm. Biochemistry. 1989 Jun 27;28(13):5606-12. doi: 10.1021/bi00439a040. Biochemistry. 1989. PMID: 2775724

7

Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin.

Lin CM, Ho HH, Pettit GR, Hamel E. Lin CM, et al. Biochemistry. 1989 Aug 22;28(17):6984-91. doi: 10.1021/bi00443a031. Biochemistry. 1989. PMID: 2819042

8

Identification of novel antimitotic agents acting at the tubulin level by computer-assisted evaluation of differential cytotoxicity data.

Paull KD, Lin CM, Malspeis L, Hamel E. Paull KD, et al. Among authors: lin cm. Cancer Res. 1992 Jul 15;52(14):3892-900. Cancer Res. 1992. PMID: 1617665

9

Interactions of 2-methoxyestradiol, an endogenous mammalian metabolite, with unpolymerized tubulin and with tubulin polymers.

Hamel E, Lin CM, Flynn E, D'Amato RJ. Hamel E, et al. Among authors: lin cm. Biochemistry. 1996 Jan 30;35(4):1304-10. doi: 10.1021/bi951559s. Biochemistry. 1996. PMID: 8573587

10

Structural interrogation of benzosuberene-based inhibitors of tubulin polymerization.

Herdman CA, Devkota L, Lin CM, Niu H, Strecker TE, Lopez R, Liu L, George CS, Tanpure RP, Hamel E, Chaplin DJ, Mason RP, Trawick ML, Pinney KG. Herdman CA, et al. Among authors: lin cm. Bioorg Med Chem. 2015 Dec 15;23(24):7497-520. doi: 10.1016/j.bmc.2015.10.012. Bioorg Med Chem. 2015. PMID: 26775540 Free PMC article.

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