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Mapping chromatin interactions at melanoma susceptibility loci and cell-type specific dataset integration uncovers distant gene targets of cis -regulation.
Thakur R, Xu M, Sowards H, Yon J, Jessop L, Myers T, Zhang T, Chari R, Long E, Rehling T, Hennessey R, Funderburk K, Yin J, Machiela MJ, Johnson ME, Wells AD, Chesi A, Grant SFA, Iles MM, Landi MT, Law MH; Melanoma Meta-Analysis Consortium; Choi J, Brown KM. Thakur R, et al. Among authors: chari r. medRxiv [Preprint]. 2024 Nov 15:2024.11.14.24317204. doi: 10.1101/2024.11.14.24317204. medRxiv. 2024. PMID: 39802764 Free PMC article. Preprint.
Genetic regulation of TERT splicing contributes to reduced or elevated cancer risk by altering cellular longevity and replicative potential.
Florez-Vargas O, Ho M, Hogshead M, Lee CH, Papenberg BW, Forsythe K, Jones K, Luo W, Teshome K, Blauwendraat C, Billingsley KJ, Kolmogorov M, Meredith M, Paten B, Chari R, Zhang C, Schneekloth JS, Machiela MJ, Chanock SJ, Gadalla S, Savage SA, Mbulaiteye SM, Prokunina-Olsson L. Florez-Vargas O, et al. Among authors: chari r. medRxiv [Preprint]. 2024 Nov 5:2024.11.04.24316722. doi: 10.1101/2024.11.04.24316722. medRxiv. 2024. PMID: 39802763 Free PMC article. Preprint.
Structural perturbation of chromatin domains with multiple developmental regulators can severely impact gene regulation and development.
Chakraborty S, Wenzlitschke N, Anderson MJ, Eraso A, Baudic M, Thompson JJ, Evans AA, Shatford-Adams LM, Chari R, Awasthi P, Dale RK, Lewandoski M, Petros TJ, Rocha PP. Chakraborty S, et al. Among authors: chari r. bioRxiv [Preprint]. 2024 Aug 3:2024.08.03.606480. doi: 10.1101/2024.08.03.606480. bioRxiv. 2024. PMID: 39372737 Free PMC article. Preprint.
Metabolic dependency mapping identifies Peroxiredoxin 1 as a driver of resistance to ATM inhibition.
Li H, Furusawa T, Cavero R, Xiao Y, Chari R, Wu X, Sun D, Hartmann O, Dhall A, Holewinski R, Andresson T, Karim B, Villamor-Payà M, Gallardo D, Day CP, Pal LR, Nair NU, Ruppin E, Aladjem MI, Pommier Y, Diefenbacher ME, Lim JM, Levine RL, Stracker TH, Weyemi U. Li H, et al. Among authors: chari r. Redox Biol. 2025 Jan 19;80:103503. doi: 10.1016/j.redox.2025.103503. Online ahead of print. Redox Biol. 2025. PMID: 39854937 Free article.
Saturation genome editing-based clinical classification of BRCA2 variants.
Sahu S, Galloux M, Southon E, Caylor D, Sullivan T, Arnaudi M, Zanti M, Geh J, Chari R, Michailidou K, Papaleo E, Sharan SK. Sahu S, et al. Among authors: chari r. Nature. 2025 Jan 8. doi: 10.1038/s41586-024-08349-1. Online ahead of print. Nature. 2025. PMID: 39779848
Between 2008 and 2022, Lower-Extremity Injuries Declined in Male Rugby Players, Whereas Noncontact Knee Injuries Showed No Decline in Female Rugby Players.
Yendluri A, Gallate ZS, Chari RR, Locke AR, Obana KK, Trofa DP, Frank RM, Parisien RL. Yendluri A, et al. Among authors: chari rr. Arthrosc Sports Med Rehabil. 2024 Jul 1;6(5):100967. doi: 10.1016/j.asmr.2024.100967. eCollection 2024 Oct. Arthrosc Sports Med Rehabil. 2024. PMID: 39534036 Free PMC article.
Metastatic organotropism in small cell lung cancer.
Krishnamurthy M, Dhall A, Schultz CW, Baird MA, Desai P, Odell J, Sahoo S, Takahashi N, Nirula M, Zhuang S, Huang Y, Schroeder B, Zhang Y, Thomas MS, Redon C, Robinson C, Thang L, Ileva L, Patel NL, Kalen JD, Varlet AA, Zuela-Sopilniak N, Jha A, Wangsa D, Butcher D, Morgan T, Afzal AN, Chari R, Baktiar K, Kumar S, Pongor L, Difilippantonio S, Aladjem MI, Pommier Y, Jolly MK, Lammerding J, Sharma AK, Thomas A. Krishnamurthy M, et al. Among authors: chari r. bioRxiv [Preprint]. 2024 Oct 8:2024.10.07.617066. doi: 10.1101/2024.10.07.617066. bioRxiv. 2024. PMID: 39416100 Free PMC article. Preprint.
374 results