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Mapping chromatin interactions at melanoma susceptibility loci and cell-type specific dataset integration uncovers distant gene targets of cis -regulation.
Thakur R, Xu M, Sowards H, Yon J, Jessop L, Myers T, Zhang T, Chari R, Long E, Rehling T, Hennessey R, Funderburk K, Yin J, Machiela MJ, Johnson ME, Wells AD, Chesi A, Grant SFA, Iles MM, Landi MT, Law MH; Melanoma Meta-Analysis Consortium; Choi J, Brown KM. Thakur R, et al. Among authors: law mh. medRxiv [Preprint]. 2024 Nov 15:2024.11.14.24317204. doi: 10.1101/2024.11.14.24317204. medRxiv. 2024. PMID: 39802764 Free PMC article. Preprint.
Massively parallel reporter assays and variant scoring identified functional variants and target genes for melanoma loci and highlighted cell-type specificity.
Long E, Yin J, Funderburk KM, Xu M, Feng J, Kane A, Zhang T, Myers T, Golden A, Thakur R, Kong H, Jessop L, Kim EY, Jones K, Chari R, Machiela MJ, Yu K; Melanoma Meta-Analysis Consortium; Iles MM, Landi MT, Law MH, Chanock SJ, Brown KM, Choi J. Long E, et al. Among authors: law mh. Am J Hum Genet. 2022 Dec 1;109(12):2210-2229. doi: 10.1016/j.ajhg.2022.11.006. Epub 2022 Nov 23. Am J Hum Genet. 2022. PMID: 36423637 Free PMC article.
Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes.
Zhang T, Choi J, Kovacs MA, Shi J, Xu M; NISC Comparative Sequencing Program; Melanoma Meta-Analysis Consortium; Goldstein AM, Trower AJ, Bishop DT, Iles MM, Duffy DL, MacGregor S, Amundadottir LT, Law MH, Loftus SK, Pavan WJ, Brown KM. Zhang T, et al. Among authors: law mh. Genome Res. 2018 Nov;28(11):1621-1635. doi: 10.1101/gr.233304.117. Epub 2018 Oct 17. Genome Res. 2018. PMID: 30333196 Free PMC article.
Overlapping genetic architecture between Parkinson disease and melanoma.
Dube U, Ibanez L, Budde JP, Benitez BA, Davis AA, Harari O, Iles MM, Law MH, Brown KM; 23andMe Research Team; Melanoma-Meta-analysis Consortium; Cruchaga C. Dube U, et al. Among authors: law mh. Acta Neuropathol. 2020 Feb;139(2):347-364. doi: 10.1007/s00401-019-02110-z. Epub 2019 Dec 16. Acta Neuropathol. 2020. PMID: 31845298 Free PMC article.
Assessment of melanoma candidate genes in a meta-analysis of 16 534 melanoma cases.
Ntritsos G, Dimou N, Kypreou K, Stefanaki I, Loizidou MA, Hadjisavvas A, Kyriacou K; Melanoma Meta-Analysis Consortium; MacGregor S, Law MH, Iles MM, Stratigos AJ, Evangelou E. Ntritsos G, et al. Among authors: law mh. J Eur Acad Dermatol Venereol. 2019 Oct;33(10):e369-e370. doi: 10.1111/jdv.15662. Epub 2019 May 26. J Eur Acad Dermatol Venereol. 2019. PMID: 31071243 Free article. No abstract available.
Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease.
Lubbe SJ, Escott-Price V, Brice A, Gasser T, Pittman AM, Bras J, Hardy J, Heutink P, Wood NM, Singleton AB, Grosset DG, Carroll CB, Law MH, Demenais F, Iles MM; Melanoma Meta-Analysis Consortium; Bishop DT, Newton-Bishop J, Williams NM, Morris HR; International Parkinson's Disease Genomics Consortium. Lubbe SJ, et al. Among authors: law mh. Neurobiol Aging. 2016 Dec;48:222.e1-222.e7. doi: 10.1016/j.neurobiolaging.2016.07.013. Epub 2016 Jul 28. Neurobiol Aging. 2016. PMID: 27640074 Free PMC article.
Correction to: Overlapping genetic architecture between Parkinson disease and melanoma.
Dube U, Ibanez L, Budde JP, Benitez BA, Davis AA, Harari O, Iles MM, Law MH, Brown KM; 23andMe Research Team; Melanoma-Meta-analysis Consortium; Cruchaga C. Dube U, et al. Among authors: law mh. Acta Neuropathol. 2020 May;139(5):963. doi: 10.1007/s00401-020-02143-9. Acta Neuropathol. 2020. PMID: 32172342 Free article.
Assessment of polygenic architecture and risk prediction based on common variants across fourteen cancers.
Zhang YD, Hurson AN, Zhang H, Choudhury PP, Easton DF, Milne RL, Simard J, Hall P, Michailidou K, Dennis J, Schmidt MK, Chang-Claude J, Gharahkhani P, Whiteman D, Campbell PT, Hoffmeister M, Jenkins M, Peters U, Hsu L, Gruber SB, Casey G, Schmit SL, O'Mara TA, Spurdle AB, Thompson DJ, Tomlinson I, De Vivo I, Landi MT, Law MH, Iles MM, Demenais F, Kumar R, MacGregor S, Bishop DT, Ward SV, Bondy ML, Houlston R, Wiencke JK, Melin B, Barnholtz-Sloan J, Kinnersley B, Wrensch MR, Amos CI, Hung RJ, Brennan P, McKay J, Caporaso NE, Berndt SI, Birmann BM, Camp NJ, Kraft P, Rothman N, Slager SL, Berchuck A, Pharoah PDP, Sellers TA, Gayther SA, Pearce CL, Goode EL, Schildkraut JM, Moysich KB, Amundadottir LT, Jacobs EJ, Klein AP, Petersen GM, Risch HA, Stolzenberg-Solomon RZ, Wolpin BM, Li D, Eeles RA, Haiman CA, Kote-Jarai Z, Schumacher FR, Al Olama AA, Purdue MP, Scelo G, Dalgaard MD, Greene MH, Grotmol T, Kanetsky PA, McGlynn KA, Nathanson KL, Turnbull C, Wiklund F; Breast Cancer Association Consortium (BCAC); Barrett’s and Esophageal Adenocarcinoma Consortium (BEACON); Colon Cancer Family Registry (CCFR); Transdisciplinary Studies of Genetic Variation in Colorectal Cancer (CORECT)… See abstract for full author list ➔ Zhang YD, et al. Among authors: law mh. Nat Commun. 2020 Jul 3;11(1):3353. doi: 10.1038/s41467-020-16483-3. Nat Commun. 2020. PMID: 32620889 Free PMC article.
Evaluating an approach for communicating integrated risk scores for melanoma.
Wallingford CK, Mothershaw A, Primiero C, Clinch T, Dawson T, Ingold N, Soyer HP, Law MH, McInerney-Leo A, Yanes T. Wallingford CK, et al. Among authors: law mh. Eur J Hum Genet. 2024 Nov 29. doi: 10.1038/s41431-024-01750-4. Online ahead of print. Eur J Hum Genet. 2024. PMID: 39613910
122 results