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Page 1
Engineered enzymes for enantioselective nucleophilic aromatic substitutions.
Lister TM, Roberts GW, Hossack EJ, Zhao F, Burke AJ, Johannissen LO, Hardy FJ, Millman AAV, Leys D, Larrosa I, Green AP. Lister TM, et al. Among authors: johannissen lo. Nature. 2025 Jan 15. doi: 10.1038/s41586-025-08611-0. Online ahead of print. Nature. 2025. PMID: 39814071
Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis.
Zhang S, Heyes DJ, Feng L, Sun W, Johannissen LO, Liu H, Levy CW, Li X, Yang J, Yu X, Lin M, Hardman SJO, Hoeven R, Sakuma M, Hay S, Leys D, Rao Z, Zhou A, Cheng Q, Scrutton NS. Zhang S, et al. Among authors: johannissen lo. Nature. 2019 Oct;574(7780):722-725. doi: 10.1038/s41586-019-1685-2. Epub 2019 Oct 23. Nature. 2019. PMID: 31645759
Redox driven B12-ligand switch drives CarH photoresponse.
Poddar H, Rios-Santacruz R, Heyes DJ, Shanmugam M, Brookfield A, Johannissen LO, Levy CW, Jeffreys LN, Zhang S, Sakuma M, Colletier JP, Hay S, Schirò G, Weik M, Scrutton NS, Leys D. Poddar H, et al. Among authors: johannissen lo. Nat Commun. 2023 Aug 21;14(1):5082. doi: 10.1038/s41467-023-40817-6. Nat Commun. 2023. PMID: 37604813 Free PMC article.
Photocobilins integrate B12 and bilin photochemistry for enzyme control.
Zhang S, Jeffreys LN, Poddar H, Yu Y, Liu C, Patel K, Johannissen LO, Zhu L, Cliff MJ, Yan C, Schirò G, Weik M, Sakuma M, Levy CW, Leys D, Heyes DJ, Scrutton NS. Zhang S, et al. Among authors: johannissen lo. Nat Commun. 2024 Mar 28;15(1):2740. doi: 10.1038/s41467-024-46995-1. Nat Commun. 2024. PMID: 38548733 Free PMC article.
A Vitamin B2 -Photocatalysed Approach to Methionine Analogues.
Knowles OJ, Johannissen LO, Crisenza GEM, Hay S, Leys D, Procter DJ. Knowles OJ, et al. Among authors: johannissen lo. Angew Chem Int Ed Engl. 2022 Dec 12;61(50):e202212158. doi: 10.1002/anie.202212158. Epub 2022 Nov 10. Angew Chem Int Ed Engl. 2022. PMID: 36250805 Free PMC article.
A Vitamin B2-Photocatalysed Approach to Methionine Analogues.
Knowles OJ, Johannissen LO, Crisenza GEM, Hay S, Leys D, Procter DJ. Knowles OJ, et al. Among authors: johannissen lo. Angew Chem Weinheim Bergstr Ger. 2022 Dec 12;134(50):e202212158. doi: 10.1002/ange.202212158. Epub 2022 Nov 10. Angew Chem Weinheim Bergstr Ger. 2022. PMID: 38505624 Free PMC article.
55 results