Okamoto H - Search Results

1

Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets.

Yamamoto H, Okamoto H. Yamamoto H, et al. Among authors: okamoto h. Biochem Biophys Res Commun. 1980 Jul 16;95(1):474-81. doi: 10.1016/0006-291x(80)90762-7. Biochem Biophys Res Commun. 1980. PMID: 6251809 No abstract available.

2

DNA strand breaks in pancreatic islets by in vivo administration of alloxan or streptozotocin.

Yamamoto H, Uchigata Y, Okamoto H. Yamamoto H, et al. Among authors: okamoto h. Biochem Biophys Res Commun. 1981 Dec 15;103(3):1014-20. doi: 10.1016/0006-291x(81)90910-4. Biochem Biophys Res Commun. 1981. PMID: 6460502 No abstract available.

3

Streptozotocin and alloxan induce DNA strand breaks and poly(ADP-ribose) synthetase in pancreatic islets.

Yamamoto H, Uchigata Y, Okamoto H. Yamamoto H, et al. Among authors: okamoto h. Nature. 1981 Nov 19;294(5838):284-6. doi: 10.1038/294284a0. Nature. 1981. PMID: 6272129 No abstract available.

4

Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis.

Uchigata Y, Yamamoto H, Kawamura A, Okamoto H. Uchigata Y, et al. Among authors: okamoto h. J Biol Chem. 1982 Jun 10;257(11):6084-8. J Biol Chem. 1982. PMID: 6281256 Free article.

We have shown previously that alloxan and streptozotocin, two major diabetogenic agents, cause DNA strand breaks in rat pancreatic islets and stimulate nuclear poly(ADP-ribose) synthetase, thereby depleting intracellular NAD level and inhibiting proinsulin synthesis (Okamoto …

We have shown previously that alloxan and streptozotocin, two major diabetogenic agents, cause DNA strand breaks in rat pancreatic islets an …

5

Poly(ADP-ribose) synthetase inhibitors enhance streptozotocin-induced killing of insulinoma cells by inhibiting the repair of DNA strand breaks.

Yamamoto H, Okamoto H. Yamamoto H, et al. Among authors: okamoto h. FEBS Lett. 1982 Aug 23;145(2):298-302. doi: 10.1016/0014-5793(82)80187-7. FEBS Lett. 1982. PMID: 6290270 Free article. No abstract available.

6

Effect of poly(ADP-ribose) synthetase inhibitor administration to rats before and after injection of alloxan and streptozotocin on islet proinsulin synthesis.

Uchigata Y, Yamamoto H, Nagai H, Okamoto H. Uchigata Y, et al. Among authors: okamoto h. Diabetes. 1983 Apr;32(4):316-8. doi: 10.2337/diab.32.4.316. Diabetes. 1983. PMID: 6299867

7

DNA strand breaks and poly(ADP-ribose) synthetase activation in pancreatic islets--a new aspect to development of insulin-dependent diabetes and pancreatic B-cell tumors.

Okamoto H, Yamamoto H. Okamoto H, et al. Princess Takamatsu Symp. 1983;13:297-308. Princess Takamatsu Symp. 1983. PMID: 6317640

8

Amelioration of diabetes mellitus in partially depancreatized rats by poly(ADP-ribose) synthetase inhibitors. Evidence of islet B-cell regeneration.

Yonemura Y, Takashima T, Miwa K, Miyazaki I, Yamamoto H, Okamoto H. Yonemura Y, et al. Among authors: okamoto h. Diabetes. 1984 Apr;33(4):401-4. doi: 10.2337/diab.33.4.401. Diabetes. 1984. PMID: 6323238

9

Identification of a novel 65-kDa cell surface receptor common to pancreatic polypeptide, neuropeptide Y and peptide YY.

Nata K, Yonekura H, Yamamoto H, Okamoto H. Nata K, et al. Among authors: okamoto h. Biochem Biophys Res Commun. 1990 Aug 31;171(1):330-5. doi: 10.1016/0006-291x(90)91397-b. Biochem Biophys Res Commun. 1990. PMID: 2168175

10

Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors.

Yamagami T, Miwa A, Takasawa S, Yamamoto H, Okamoto H. Yamagami T, et al. Among authors: okamoto h. Cancer Res. 1985 Apr;45(4):1845-9. Cancer Res. 1985. PMID: 2983889

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