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(S)-spiro[(1,3-diazacyclopent-1-ene)-5,2'-(7'-methyl-1',2',3',4'- tetrahydronaphthalene)]: resolution, stereospecific synthesis, and preliminary pharmacological characterization as a partial alpha-adrenergic agonist.
Cordi AA, Lacoste JM, Le Borgne F, Herve Y, Vaysse-Ludot L, Descombes JJ, Courchay C, Laubie M, Verbeuren TJ. Cordi AA, et al. Among authors: lacoste jm. J Med Chem. 1997 Aug 29;40(18):2931-5. doi: 10.1021/jm970282m. J Med Chem. 1997. PMID: 9288175
S18616, a highly potent, spiroimidazoline agonist at alpha(2)-adrenoceptors: I. Receptor profile, antinociceptive and hypothermic actions in comparison with dexmedetomidine and clonidine.
Millan MJ, Dekeyne A, Newman-Tancredi A, Cussac D, Audinot V, Milligan G, Duqueyroix D, Girardon S, Mullot J, Boutin JA, Nicolas JP, Renouard-Try A, Lacoste JM, Cordi A. Millan MJ, et al. Among authors: lacoste jm. J Pharmacol Exp Ther. 2000 Dec;295(3):1192-205. J Pharmacol Exp Ther. 2000. PMID: 11082457
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