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Search for the familial Alzheimer's disease gene.
St George-Hyslop P, Polinsky R, Haines J, Nee L, Tanzi R, Conneally P, Growdon J, Myers R, Pollen D, Drachman D, et al. St George-Hyslop P, et al. J Neural Transm Suppl. 1987;24:13-21. J Neural Transm Suppl. 1987. PMID: 2890708
Lewy bodies contain altered alpha-synuclein in brains of many familial Alzheimer's disease patients with mutations in presenilin and amyloid precursor protein genes.
Lippa CF, Fujiwara H, Mann DM, Giasson B, Baba M, Schmidt ML, Nee LE, O'Connell B, Pollen DA, St George-Hyslop P, Ghetti B, Nochlin D, Bird TD, Cairns NJ, Lee VM, Iwatsubo T, Trojanowski JQ. Lippa CF, et al. Among authors: pollen da. Am J Pathol. 1998 Nov;153(5):1365-70. doi: 10.1016/s0002-9440(10)65722-7. Am J Pathol. 1998. PMID: 9811326 Free PMC article.
Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder.
St George-Hyslop PH, Haines JL, Farrer LA, Polinsky R, Van Broeckhoven C, Goate A, McLachlan DR, Orr H, Bruni AC, Sorbi S, Rainero I, Foncin JF, Pollen D, Cantu JM, Tupler R, Voskresenskaya N, Mayeux R, Growden J, Fried VA, Myers RH, Nee L, Backhovens H, Martin JJ, Rossor M, Owen MJ, Mullan M, Percy ME, Karlinsky H, Rich S, Heston L, Montesi M, Mortilla M, Nacmias N, Gusella JF, Hardy JA; FAD Collaborative Study Group, et al. St George-Hyslop PH, et al. Nature. 1990 Sep 13;347(6289):194-7. doi: 10.1038/347194a0. Nature. 1990. PMID: 2395471
Alzheimer's disease and possible gene interaction.
St George-Hyslop P, McLachlan DC, Tsuda T, Rogaev E, Karlinsky H, Lippa CF, Pollen D. St George-Hyslop P, et al. Science. 1994 Jan 28;263(5146):537. doi: 10.1126/science.8290965. Science. 1994. PMID: 8290965 No abstract available.
72 results